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Acute Biocompatibility of X-ray Visible Bioabsorbable Bone Plate Coated with β-Tricalcium Phosphate and Poly(lactic-co-glycolic acid)

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Abstract

To allow X-ray visibility, we coated a bioabsorbable bone plate in clinical use (PLT-1031, Inion, Finland) with a layer made of a composite of beta-tricalcium phosphate (β-TCP) and poly(lactic-co-glycolic acid) (PLGA) (i.e., β-TCP/PLGA plate) and assessed its in vivo acute biocompatibility for 4 months. For this, we fixed an intact Inion plate and β-TCP/PLGA plate on the left and right humeri of a New Zealand White rabbit, respectively. According to the X-ray imaging, the β-TCP/PLGA plate was observable for 2 weeks after the implantation while the intact plate was not visible during the whole tested period. To evaluate the biocompatibility of the plate, we performed a histological analysis with hematoxylin and eosin (H&E) staining on the tissues obtained at scheduled times. After being tested for 4 months, the overall biocompatibility of the β-TCP/PLGA plate was similar to that of the intact Inion plate and there was also no significant difference in bone repair process between the two plates. On the 5 day after the implantation, both plates exhibited a similar state of early reparative tissue reaction, showing tissue necrosis, abscess formation, and neutrophilic infiltration. In the 2 weeks, inflammation and granulation tissue formation around the plate extended to the skeletal muscle and fat tissue. This gradually decreased through the end of the experiment with only a few foreign body giant cells and macrophages remaining in the fibrotic tissue.

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Authors and Affiliations

  1. Graduate School of Public Health, Seoul National University, Seoul, 08826, Korea

    Hye Sook Min

  2. Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, College of Medicine, Seoul National University, Seoul, 03080, Korea

    Woojune Hur, Hye Jeong Min & Tae Hyun Choi

  3. Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, Korea

    Woojune Hur & Hye Jeong Min

  4. Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Korea

    Won Seok Lee, Sung Yoon Choi & Young Bin Choy

  5. Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Korea

    Seung Ho Lee & Young Bin Choy

  6. Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 03080, Korea

    Young Bin Choy

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  1. Hye Sook Min
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  2. Woojune Hur
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  3. Won Seok Lee
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  5. Hye Jeong Min
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Correspondence to Young Bin Choy or Tae Hyun Choi.

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These authors contributed equally as first author to this work.

The image from this article is used as the cover image of the Volume 24, Issue 5.

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Min, H.S., Hur, W., Lee, W.S. et al. Acute Biocompatibility of X-ray Visible Bioabsorbable Bone Plate Coated with β-Tricalcium Phosphate and Poly(lactic-co-glycolic acid). Macromol. Res. 24, 471–477 (2016). https://doi.org/10.1007/s13233-016-4064-y

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  • DOI: https://doi.org/10.1007/s13233-016-4064-y

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