Skip to main content

Advertisement

SpringerLink
Log in

Osteo-cementum Producing Odontogenic Myxomas. A Literature Review of a Distinctive Variant

  • Review Paper
  • Published:
Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Introduction

Odontogenic myxoma (OM) is a benign neoplasm of mesenchymal origin with growth characteristics, clinical behaviour and radiographic presentation similar to those of ameloblastoma. It is an intraosseous neoplasm characterized by stellate and spindleshaped cells embedded in loose myxoid or mucoid extracellular matrix. Although sometimes bony islands that represent residual trabeculae are found throughout the lesion, the formation of osteocement-like calcified spherules within the tumour is an extremely rare phenomenon.

Review

We report a very rare case of an OM of the left maxilla exhibiting osteo-cementous metaplasia within the substance of the tumour and beyond the facial skeleton, in the nasopharynx. A review of all four similar cases previously reported in the literature is also presented.

Conclusion

Whether or not this property to produce significant amounts of bone can be associated with a different biological behavior for this specific variant of OM remains to be proved with the study of more similar cases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Marx RE, Stern D (2002) Odontogenic tumors: hamartomas and neoplasms. In: Stern D, Marx RE (eds) Oral and maxillofacial pathology: a rationale for diagnosis and treatment. Quintessence Publishing, Illinois, pp 668–670

    Google Scholar 

  2. Barnes L, Eveson JW, Reichart P, Sidransky D (2005) WHO classification of tumours: pathology and genetics of head and neck tumours. IARC Press, Lyon

    Google Scholar 

  3. Osterdock RJ, Greene S, Mascott CR, Amedee R, Crawford BE (2001) Primary myxoma of the temporal bone in a 17-year-old boy: case report. Neurosurgery 48(4):945–947

    CAS  PubMed  Google Scholar 

  4. Sundaram M, Janney C, McDonald DJ (2000) Myxoma of the humerus: an exceptional site of origin. Skeletal Radiol 29(1):57–60

    Article  CAS  PubMed  Google Scholar 

  5. Regezi JA, Sciubba JJ, Jordan RCK (2008) Odontogenic Tumors. In: Regezi JA, Sciubba JJ, Jordan RCK (eds) Oral pathology, clinical pathologic correlations vol 2, 5th edn. Elsevier, Philadelphia, pp 814–818

    Google Scholar 

  6. Gnepp DR (2009) Odontogenic Cysts and Tumors. In: Gnepp DR (ed) Diagnostic surgical pathology of the head and neck, 2nd edn. Elsevier, Philadelphia, pp 829–831

    Google Scholar 

  7. Neville BW, Damm DD, White DH (eds) (2003) Colour atlas of clinical pathology, 2nd edn. BC Decker Inc, Hamilton

    Google Scholar 

  8. Cardesa A, Slootweg PJ (eds) (2006) Pathology of the head and neck. Springer, Heidelberg

    Google Scholar 

  9. Lin YL, Basile JR (2010) A case of odontogenic myxoma with unusual histological features mimicking a fibro-osseous process. Head Neck Pathol 4:253–256

    Article  PubMed Central  PubMed  Google Scholar 

  10. Oygür T, Dolanmaz D, Tokman B, Bayraktar S (2001) Odontogenic myxoma containing osteocement-like spheroid bodies: report of a case with an unusual histopathological feature. J Oral Pathol Med 30:504–506

    Article  PubMed  Google Scholar 

  11. Stout AP (1948) Myxoma, the tumor of primitive mesenchyme. Ann Surg 127:706–719

    Article  CAS  PubMed  Google Scholar 

  12. Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJW (2004) Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg 33:333–337

    Article  PubMed  Google Scholar 

  13. Schmidt-Westhausen A, Becker J, Schuppan D, Burkhardt A, Reichart PA (1994) Odontogenic myxoma-characterisation of the extracellular matrix (ECM) of the tumour stroma. Eur J Cancer B Oral Oncol 30B:377–380

    Article  CAS  PubMed  Google Scholar 

  14. Slootweg PJ, van den Bos T, Straks W (1985) Glycosaminoglycans in myxoma of the jaw: a biochemical study. J Oral Pathol 14:299–306

    Article  CAS  PubMed  Google Scholar 

  15. Lo Muzio L, Nocini P, Favia G, Procaccini M, Mignogna MD (1996) Odontogenic myxoma of the jaws: a clinical, radiologic, immunohistochemical, and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82:426–433

    Article  CAS  PubMed  Google Scholar 

  16. Noffke CEE, Raubenheimer EJ, Chabikuli NJ, Bouckaert MMR (2007) Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:101–109

    Article  PubMed  Google Scholar 

  17. Rennie JS, MacDonald DG, Critchlow HA (1985) Unusual myxomatous odontogenic tumour with calcification. Int J Oral Surg 14:307–310

    Article  CAS  PubMed  Google Scholar 

  18. Odell EW, Morgan PR (eds) (1998) Biopsy pathology of the oral tissues. Chapman & Hall Medical, London

    Google Scholar 

  19. Makek M (1983) Clinical pathology of fibro-osteo-cemental lesions. In: Makek M (ed) The cranio-facial and jaw bones. S. Karger, Basel, p 100

    Google Scholar 

  20. Lahey E, Woo SB, Park HK (2013) Odontogenic myxoma with diffuse calcifications: a case report and review of the literature. Head Neck Pathol. 7(1):97–102

    Article  PubMed Central  PubMed  Google Scholar 

  21. Rocha AC, Gaujac C, Ceccheti MM, Amato-Filho G, Machado GG (2009) Treatment of recurrent mandibular myxoma by curettage and cryotherapy after thirty years. Clinics (Sao Paulo) 64(2):149–152

    Article  Google Scholar 

Download references

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Oral and Maxillofacial Surgery Department, K.A.T General Hospital of Athens, Athens, Greece

    George Rallis

  2. Oral and Maxillofacial Surgery Department, King’s Hospital, London, UK

    Panagiotis Dais

  3. Oral and Maxillofacial Surgery Department, Athens, Greece

    George Kostakis

  4. Department of Oral and Maxillofacial Surgery, Royal Devon and Exeter Hospital, Exeter, UK

    Panagiotis Stathopoulos

  5. Flat 11, Gorse House, Medley Court, EX4 2QJ, Exeter, UK

    Panagiotis Stathopoulos

Authors
  1. George Rallis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Panagiotis Dais
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. George Kostakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Panagiotis Stathopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Panagiotis Stathopoulos.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rallis, G., Dais, P., Kostakis, G. et al. Osteo-cementum Producing Odontogenic Myxomas. A Literature Review of a Distinctive Variant. J. Maxillofac. Oral Surg. 14, 176–181 (2015). https://doi.org/10.1007/s12663-014-0645-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12663-014-0645-5

Keywords

Search

Navigation