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Nutrition and the biology of human ageing: Cognitive decline/food intake & caloric restriction

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The journal of nutrition, health & aging

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References

  1. Stranahan, A.M. & Mattson, M.P. Recruiting adaptive cellular stress responses for successful brain ageing. Nat. Rev. Neurosci. 2012;13, 209–216

    PubMed  CAS  Google Scholar 

  2. Oddo, S. et al. Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003;39, 409–421

    Article  PubMed  CAS  Google Scholar 

  3. Halagappa, V.K. et al. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer’s disease. Neurobiol. Dis. 2007;26, 212–220

    Article  PubMed  CAS  Google Scholar 

  4. Yang, J.L., Tadokoro, T., Keijzers, G., Mattson, M.P., & Bohr, V.A. Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J. Biol. Chem. 2010;285, 28191–28199

    Article  PubMed  CAS  Google Scholar 

  5. Mattson, M.P. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab 2012;16, 706–722

    Article  PubMed  CAS  Google Scholar 

  6. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956;11, 298–300

    Article  PubMed  CAS  Google Scholar 

  7. Durieux, J., Wolff, S., & Dillin, A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011;144, 79–91

    Article  PubMed  CAS  Google Scholar 

  8. Ingalls A.M., Dickie, M.M., & Snell G.D. Obese, a new mutation in the house mouse. J. Hered. 1950;41, 317–318

    PubMed  CAS  Google Scholar 

  9. Farooqi, I.S. et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest 2002;110, 1093–1103

    PubMed  CAS  Google Scholar 

  10. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372, 425–432

    Article  PubMed  CAS  Google Scholar 

  11. Ahima, R.S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382, 250–252

    Article  PubMed  CAS  Google Scholar 

  12. Frisch, R.E. Weighing the evidence. Lancet 1985;2, 952

    Article  PubMed  CAS  Google Scholar 

  13. Welt, C.K. et al. Recombinant human leptin in women with hypothalamic amenorrhea. N. Engl. J. Med. 2004;351, 987–997

    Article  PubMed  CAS  Google Scholar 

  14. Roth, J.D. et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc. Natl. Acad. Sci. U. S. A 2008;105, 7257–7262

    Article  PubMed  CAS  Google Scholar 

  15. Barsh, G.S. & Schwartz, M.W. Genetic approaches to studying energy balance: perception and integration. Nat. Rev. Genet. 2002;3, 589–600

    Article  PubMed  CAS  Google Scholar 

  16. Knight, Z.A. et al. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell 2012;151, 1126–1137

    Article  PubMed  CAS  Google Scholar 

  17. Johnson, J.B. et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic. Biol. Med. 2007;42, 665–674

    Article  PubMed  CAS  Google Scholar 

  18. Harvie, M.N. et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int. J. Obes. (Lond) 2011;35, 714–727

    Article  CAS  Google Scholar 

  19. Kossoff, E.H. & Hartman, A.L. Ketogenic diets: new advances for metabolism-based therapies. Curr. Opin. Neurol. 2012;25, 173–178

    Article  PubMed  CAS  Google Scholar 

  20. Hartman, A.L. Neuroprotection in metabolism-based therapy. Epilepsy Res. 2012;100, 286–294

    Article  PubMed  CAS  Google Scholar 

  21. Milder, J. & Patel, M. Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res. 2012;100, 295–303

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Nestlé Research Center, Lausanne, Switzerland

    J. Le Coutre

  2. Laboratory of Neurosciences, National Institute on Aging, Baltimore, USA

    M. P. Mattson

  3. University of California, Berkeley, USA

    A. Dillin

  4. Rockefeller University, New York, USA

    J. Friedman

  5. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, USA

    B. Bistrian

Authors
  1. J. Le Coutre
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  2. M. P. Mattson
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  3. A. Dillin
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  4. J. Friedman
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  5. B. Bistrian
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Correspondence to J. Le Coutre.

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Le Coutre, J., Mattson, M.P., Dillin, A. et al. Nutrition and the biology of human ageing: Cognitive decline/food intake & caloric restriction. J Nutr Health Aging 17, 717–720 (2013). https://doi.org/10.1007/s12603-013-0375-2

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  • DOI: https://doi.org/10.1007/s12603-013-0375-2

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