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Right ventricular diastolic dysfunction in patients with left ventricular hypertrophy: analysis of right ventricular myocardial relaxation using two-dimensional speckle tracking imaging

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Abstract

Background

Although several previous studies have suggested the presence of right ventricular (RV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM) and those with hypertensive left ventricular hypertrophy (HT-LVH), the mechanisms are still unclear. This study aimed to clarify the relationship between the RV global diastolic dysfunction in these patients and the regional myocardial diastolic function, including synchronicity of the interventricular septum and RV free wall.

Methods

In 20 age-matched patients with HT-LVH, 20 patients with HCM and 22 control subjects without pulmonary hypertension, RV isovolumic relaxation time (IRTR) was measured using continuous-wave Doppler echocardiography. The early diastolic peak strain rate (E SR) and time from QRS to E SR (T–E SR) were measured in the apical, mid-ventricular and basal segments of the interventricular septum and RV free wall using two-dimensional speckle tracking imaging (2DST).

Results

IRTR was more prolonged both in HT-LVH and in HCM than in the controls. The averaged septal E SR was reduced both in HT-LVH and in HCM (P < 0.0001, respectively), but the averaged RV free wall E SR was decreased only in HCM (P = 0.0007). E SR averaged for six septal and RV free wall segments was correlated with IRTR (r = −0.46, P = 0.0001). Neither intergroup difference nor correlation with IRTR was observed in a coefficient of variation of T–E SR for the six segments.

Conclusions

RV global diastolic function is impaired in patients with HT-LVH and HCM due to relaxation abnormalities, not an asynchrony, of the myocardium surrounding the RV cavity. The detection of RV free wall relaxation abnormality using 2DST may be useful to differentiate HCM from HT-LVH.

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Authors and Affiliations

  1. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan

    Sanae Kaga, Satomi Omotehara, Mamiko Inoue, Shinobu Yokoyama, Mutsumi Nishida, Chikara Shimizu & Kazuhiko Matsuno

  2. Faculty of Health Sciences, Hokkaido University Graduate School, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan

    Taisei Mikami, Hisao Onozuka & Ayumu Abe

  3. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Satoshi Yamada, Masako Okada, Hiroshi Komatsu & Hiroyuki Tsutsui

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  1. Sanae Kaga
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  2. Taisei Mikami
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  3. Hisao Onozuka
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Correspondence to Taisei Mikami.

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Kaga, S., Mikami, T., Onozuka, H. et al. Right ventricular diastolic dysfunction in patients with left ventricular hypertrophy: analysis of right ventricular myocardial relaxation using two-dimensional speckle tracking imaging. J Echocardiogr 7, 25–33 (2009). https://doi.org/10.1007/s12574-009-0009-1

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  • DOI: https://doi.org/10.1007/s12574-009-0009-1

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