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Fabrication of PDMS passive micromixer by lost-wax casting

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Abstract

Microfluidic devices have attracted considerable attention for their applicability in disease detection, health care, and environmental monitoring. However, manufacturing at the microscale can be exceedingly difficult, particularly when dealing with devices with an intricate geometry. Most of the manufacturing methods used for microfluidic devices are unable to produce anything more complex than a simple 2.5D structure, which necessitates the bonding of multiple layers to produce a complete 3D structure. This study employs the lost-wax casting method, which is commonly used for the precision casting of metals, in the fabrication of a passive micromixer with two-layer structure using polydimethylsiloxane (PDMS) in a single-step process. The wax pattern was obtained by injection molding, whereupon PDMS was cast in the mold to produce a micromixer after dewaxing. Our results demonstrate the high fidelity of the replication process from the wax pattern to the PDMS micromixer. Furthermore, with the exception of the glass cover, no bonding is required to join multiple layers in the formation of the structure. Compared to other microfabrication methods, such as molding injection and hot embossing, the lost-wax casting method in this study is able to produce microdevices with more complex geometry without the problem of misalignment between bonding layers.

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References

  1. Manz, A., Graber, N., and Widmer, H. M., “Miniaturized Total Chemical Analysis Systems: A Novel Concept for Chemical Sensing,” Sensors and actuators B: Chemical, Vol. 1, No. 1, pp. 244–248, 1990.

    Article  Google Scholar 

  2. Lee, W. G., Kim, Y.-G., Chung, B. G., Demirci, U., and Khademhosseini, A., “Nano/Microfluidics for Diagnosis of Infectious Diseases in Developing Countries,” Advanced Drug Delivery Reviews, Vol. 62, No. 4, pp. 449–457, 2010.

    Article  Google Scholar 

  3. Yager, P., Edwards, T., Fu, E., Helton, K., Nelson, K., et al., “Microfluidic Diagnostic Technologies for Global Public Health,” Nature, Vol. 442, No. 7101, pp. 412–418, 2006.

    Article  Google Scholar 

  4. Marle, L. and Greenway, G. M., “Microfluidic Devices for Environmental Monitoring,” TrAC Trends in Analytical Chemistry, Vol. 24, No. 9, pp. 795–802, 2005.

    Article  Google Scholar 

  5. Chen, P. C. and Wang, Z. P., “A Rapid and Low Cost Manufacturing for Polymeric Microfluidic Devices,” Advanced Materials Research, Vol. 579, pp. 348–356, 2012.

    Article  Google Scholar 

  6. Chen, P.-C., Pan, C.-W., Lee, W.-C., and Li, K.-M., “An Experimental Study of Micromilling Parameters to Manufacture Microchannels on a PMMA Substrate,” The International Journal of Advanced Manufacturing Technology, Vol. 71, No. 9–12, pp. 1623–1630, 2014.

    Article  Google Scholar 

  7. Becker, H. and Gärtner, C., “Polymer Microfabrication Technologies for Microfluidic Systems,” Analytical and Bioanalytical Chemistry, Vol. 390, No. 1, pp. 89–111, 2008.

    Article  Google Scholar 

  8. Waldbaur, A., Rapp, H., Länge, K., and Rapp, B. E., “Let there be Chip-Towards Rapid Prototyping of Microfluidic Devices: One-Step Manufacturing Processes,” Analytical Methods, Vol. 3, No. 12, pp. 2681–2716, 2011.

    Article  Google Scholar 

  9. Browne, A. W., Rust, M. J., Jung, W., Lee, S. H., and Ahn, C. H., “A Rapid Prototyping Method for Polymer Microfluidics with Fixed Aspect Ratio and 3D Tapered Channels,” Lab on a Chip, Vol. 9, No. 20, pp. 2941–2946, 2009.

    Article  Google Scholar 

  10. Kim, B. S., Lee, K. G., Choi, H. W., Lee, T. J., Park, K.-J., et al., “Facile Fabrication of Plastic Template for Three-Dimensional Micromixer-Embedded Microfluidic Device,” Biochip Journal, Vol. 7, No. 2, pp. 104–111, 2013.

    Article  Google Scholar 

  11. Comina, G., Suska, A., and Filippini, D., “PDMS Lab-on-a-Chip Fabrication using 3D Printed Templates,” Lab Chip, Vol. 14, No. 2, pp. 424–430, 2013.

    Article  Google Scholar 

  12. Díaz-González, M. and Baldi, A., “Fabrication of Biofunctionalized Microfluidic Structures by Low-Temperature Wax Bonding,” Analytical Chemistry, Vol. 84, No. 18, pp. 7838–7844, 2012.

    Article  Google Scholar 

  13. Hou, L., Zhang, W., and Zhu, L., “Preparation of PDMS Microfluidic Devices based on Drop-on-Demand Generation of Wax Molds,” Analytical Methods, Vol. 6, No. 13, pp. 4716–4722, 2014.

    Article  Google Scholar 

  14. Clegg, A. J., “Precision Casting Processes,” Pergamon, 1991.

    Google Scholar 

  15. Kalpakjian, S. and Schmid, S., “Manufacturing Engineering & Technology,” Prentice Hall, 7th Ed., pp. 256–293, 2013.

    Google Scholar 

  16. Nguyen, N.-T. and Wu, Z., “Micromixers-A Review,” Journal of Micromechanics and Microengineering, Vol. 15, No. 2, pp. R1–R16, 2005.

    Article  Google Scholar 

  17. Hessel, V., Löwe, H., and Schönfeld, F., “Micromixers-A Review on Passive and Active Mixing Principles,” Chemical Engineering Science, Vol. 60, No. 8, pp. 2479–2501, 2005.

    Article  Google Scholar 

  18. Chung, C. and Chen, Y.-J., “Fabrication of Three Dimensional Structures in Polymer-Based Microchannel with Lost-Wax Casting,” Proc. of 9th International Conference on Mivromanufacturing, 26C3-38, 2014.

    Google Scholar 

  19. Schönfeld, F., Hessel, V., and Hofmann, C., “An Optimised Splitand-Recombine Micro-Mixer with Uniform ‘Chaotic’ Mixing,” Lab on a Chip, Vol. 4, No. 1, pp. 65–69, 2004.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan

    Chunhui Chung, Yann-Jiun Chen & Pin-Chaun Chen

  2. Department of Mechanical Engineering, National Cheng Kung University, Tainan, 701, Taiwan

    Chia-Yuan Chen

Authors
  1. Chunhui Chung
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  2. Yann-Jiun Chen
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  3. Pin-Chaun Chen
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  4. Chia-Yuan Chen
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Correspondence to Chunhui Chung.

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Chung, C., Chen, YJ., Chen, PC. et al. Fabrication of PDMS passive micromixer by lost-wax casting. Int. J. Precis. Eng. Manuf. 16, 2033–2039 (2015). https://doi.org/10.1007/s12541-015-0264-1

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  • DOI: https://doi.org/10.1007/s12541-015-0264-1

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