Skip to main content
SpringerLink
Log in

Behavior of acetyl-l-carnitine injections (Nicetile® fiale) with different drugs used for combined therapy

  • Original Research
  • Published:
Advances in Therapy Aims and scope Submit manuscript

Abstract

Introduction

Acetyl-l-carnitine (Nicetile® fiale; Biofutura Pharma S.p.A., Sigma Tau group, Milano, Italy) is a compound widely used for the treatment of many diseases, such as neuropathies, diabetic polyneuropathy, and Parkinson’s disease. It is frequently administered via the intramuscular route with other drugs, such as steroidal anti.inflammatories, muscle relaxants, and vitamins.

Methods

In the present study the behavior of acetyl-l-carnitine injections (Nicetile® fiale) with different drugs used for combined therapy was studied. Physicochemical properties including color, clarity, pH, and drug content were observed before and after mixing at room temperature.

Results

The content of all the active drugs after mixing remained optimal within 10% of their nominal values.

Conclusions

The measurements demonstrate the physicochemical compatibility between Nicetile fiale and the other tested products, meaning that there is no evidence of interactions and degradation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Beal MF. Bioenergetic approaches for neuroprotection in Parkinson’s disease. Ann Neurol. 2003;53(suppl. 3):S39–S48.

    Article  CAS  PubMed  Google Scholar 

  2. Ashworth N. Carpal tunnel syndrome. Am Fam Physician. 2007;75:381–383.

    PubMed  Google Scholar 

  3. Alfonso C, Jann S, Massa R, Torreggiani A. Diagnosis, treatment and follow-up of the carpal tunnel syndrome. Neurol Sci. 2010;31:1–10.

    Article  Google Scholar 

  4. De Grandis D. Tolerability and efficacy of l-acetyl-carnitine in the treatment of patients with peripheral neuropaties. A short term, open multicenter study. Clin Drug Invest. 1998;16:73–79.

    Article  Google Scholar 

  5. Schenone A. Diagnosi, classificazione e principi di terapia delle neuropatie periferiche. Ital J Neurol Sci. 2007;2:12–20.

    Google Scholar 

  6. Willison JH, Winer JB. Clinical evaluation and investigation of neuropathy. J Neurol Neurosurg Psychiatr. 2003;74(suppl. II):ii3–ii8.

    Google Scholar 

  7. Hart AM, Wiberg M, Terenghi G. Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-l-carnitine treatment. Neurosci Lett. 2002;334:181–185.

    Article  Google Scholar 

  8. Blum K, Seifter E, Seifter J. The pharmacology of d- and l- carnitine and d- and l-acetylcarnitine: comparison with choline and acetylcholine. J Pharmacol Exp Ther. 1971;178:331–338.

    CAS  PubMed  Google Scholar 

  9. Scarpini E, Doneda P, Pizzul S, et al. l-Carnitine and acetyl-l-carnitine in human nerves from normal and diabetic subjects. J Peripher Nerv Syst. 1996;1:157–163.

    CAS  PubMed  Google Scholar 

  10. Ido Y, McHowan J, Chang KC, et al. Neural dysfunction and metabolic imbalances in diabetics rats: prevention by acetyl-l-carnitine. Diabetes. 1994;43:1469–1477.

    Article  CAS  PubMed  Google Scholar 

  11. Sima AA, Calvani M, Mehra M, Amato A, Acetyl-l-carnitine Study Group. Acetyl-l-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy, an analysis of two randomized placebo-controlled trials. Diabetes Care. 2005;28:89–94.

    Article  CAS  PubMed  Google Scholar 

  12. Hathcock JN, Shao A. Risk assessment for carnitine. Regul Toxicol Pharmacol. 2006;4:23–28.

    Article  Google Scholar 

  13. Anacardio R, Perilli O, Pagnanelli F, et al. Physicochemical compatibility between thiocolchicoside injections (Miotens®) and pharmaceutical products frequently used for combined therapy. Farmaco. 2002;57:925–930.

    Article  CAS  PubMed  Google Scholar 

  14. Yalkowsky SH. Formulation-related problems associated with intravenous drug delivery. J Pharm Sci. 1998;87:787–796.

    Article  CAS  PubMed  Google Scholar 

  15. Pifferi G. Compatibilità chimico-fisica tra tiocolchicoside e farmaci antinfiammatori non steroidei. Boll Chim Farm. 1993;132:203–209.

    CAS  PubMed  Google Scholar 

  16. Carlucci G, Gentile MM, Bartolini S, Anacardio R. Physicochemical compatibility between ketoprofen lysine salt injections (Oki® fiale PG060) and pharmaceutical products frequently used for combined therapy. Boll Chim Farm. 2004;1:15–19.

    Google Scholar 

  17. Anacardio R, Perilli O, Pagnanelli F, et al. Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene®) and pharmaceutical products frequently used for combined therapy by intravenous administration. J Pharm Biomed Anal. 2003;32:1235–1241.

    Article  CAS  PubMed  Google Scholar 

  18. Amidžić R, Brboric J, Čudina O, Vladimirov S. RPHPLC determination of vitamins B1, B3, B6, folic acid and B12 in multivitamin tablets. J Serb Chem Soc. 2005;70:1229–1235.

    Article  Google Scholar 

  19. Aslam J, Mohajir MS, Khan SA, Khan AQ. HPLC analysis of water-soluble vitamins (B1, B2, B3, B5, B6) in in vitro and ex vitro germinated chickpea (Cicer arietinum L.). Afr J Biotechnol. 2008;7:2310–2314.

    CAS  Google Scholar 

  20. Thomas S, Kumar R, Sharma A, Issarani R, Nagori BP. Stability-indicating HPLC method for determination of vitamins B1, B2, B3 and B6 in pharmaceutical liquid dosage form. Ind J Chem Technol. 2008;15:598–603.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Calabria, 87036, Arcavacata di Rende, Italy

    Maria Stefania Sinicropi & Francesco Leone

  2. Department of Pharmaco-Biology, University of Calabria, 87036, Arcavacata di Rende, Italy

    Nicola Rovito & Giuseppe Genchi

Authors
  1. Maria Stefania Sinicropi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Leone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicola Rovito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giuseppe Genchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Maria Stefania Sinicropi or Giuseppe Genchi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sinicropi, M.S., Leone, F., Rovito, N. et al. Behavior of acetyl-l-carnitine injections (Nicetile® fiale) with different drugs used for combined therapy. Adv Therapy 27, 547–554 (2010). https://doi.org/10.1007/s12325-010-0055-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12325-010-0055-0

Keywords

Search

Navigation