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Die Chemische Biologie beschreitet neue Wege in der Chromatinforschung

Histonmodifikation

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Abstract

Histones package DNA into chromatin and regulate genes through a multitude of histone modifications. A ‘histone code’ hypothesis has been put forth that ascribes different patterns of histone modifications specific biological functions. This article highlights recent chemical biological approaches to uncover the complex cross-talk between histone marks and chromatin activity.

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Literatur

  1. Turner BM (2001) Chromatin and Gene Regulation. Blackwell Science Ltd., Oxford

    Book  Google Scholar 

  2. Allis CD, Muir TW (2011) Spreading chromatin into chemical biology. Chembiochem 12:264–279

    Article  PubMed  CAS  Google Scholar 

  3. Schwarzer D (2010) Chemical tools in chromatin research. J Pept Sci 16:530–537

    Article  PubMed  CAS  Google Scholar 

  4. Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403:41–45

    Article  PubMed  CAS  Google Scholar 

  5. Hackenberger CP, Schwarzer D (2008) Chemoselective ligation and modification strategies for peptides and proteins. Angew Chem Int Ed Engl 47:10030–10074

    Article  PubMed  CAS  Google Scholar 

  6. Dawson PE, Muir TW, Clark-Lewis I et al. (1994) Synthesis of proteins by native chemical ligation. Science 266:776–779

    Article  PubMed  CAS  Google Scholar 

  7. Piotukh K, Geltinger B, Heinrich N et al. (2011) Directed evolution of sortase A mutants with altered substrate selectivity profiles. J Am Chem Soc 133:17536–17539

    Article  PubMed  CAS  Google Scholar 

  8. Nikolov M, Stützer A, Mosch K et al. (2011) Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Mol Cell Proteomics 10:M110.005371

    Article  PubMed  Google Scholar 

  9. Bartke T, Vermeulen M, Xhemalce B et al. (2011) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143:470–484

    Article  Google Scholar 

  10. Shogren-Knaak M, Ishii H, Sun JM et al. (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311:844–847

    Article  PubMed  CAS  Google Scholar 

  11. Fierz B, Chatterjee C, McGinty RK et al. (2011) Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat Chem Biol 7:113–119

    Article  PubMed  CAS  Google Scholar 

  12. Taunton J, Hassig CA, Schreiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408–411

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Interfakultäres Institut für Biochemie, Universität Tübingen, Tübingen, Germany

    Dirk Schwarzer

  2. Interfakultäres Institut für Biochemie, Eberhard Karls Universität Tübingen, Hoppe-Seyler-Straße 4, D-72076, Tübingen, Germany

    Dirk Schwarzer

Authors
  1. Dirk Schwarzer
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Corresponding author

Correspondence to Dirk Schwarzer.

Additional information

Dirk Schwarzer Jahrgang 1972. 1993–2002 Chemiestudium und Promotion an der Universität Marburg. 2003–2006 Postdoc an der Johns Hopkins University, Baltimore, MD, USA. 2006–2007 Postdoc an der Universität Dortmund. 2007–2011 Leiter einer Emmy-Noether-Gruppe am Leibniz-Institut für Molekulare Pharmakologie (FMP) in Berlin. Seit 2011 Professor für Biochemie am Interfakultären Institut für Biochemie, Universität Tübingen.

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Schwarzer, D. Die Chemische Biologie beschreitet neue Wege in der Chromatinforschung. Biospektrum 18, 248–250 (2012). https://doi.org/10.1007/s12268-012-0169-9

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  • DOI: https://doi.org/10.1007/s12268-012-0169-9

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