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Evolutionary Aspects of Obesity, Insulin Resistance, and Cardiovascular Risk

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Abstract

Cardiovascular disease (CVD) is still virtually absent in those rare populations with minimal Western dietary influence. To date, exercise, altered fats, fibre, anti-oxidants or Mediterranean diet do not appear to overcome the discrepancy in CVD between hunter-gatherer and Western populations. The CVD risk factors of obesity and diabetes are driven by increased caloric intake, with carbohydrates potentially implicated. Paradoxically, non-Westernized diets vary widely in macronutrients, glycemic and insulinemic indices, yet apparently produce no obesity or CVD regardless, even with abundant food. 'Ancestral' grain-free whole-food diet may represent the best lifestyle intervention for obesity and CVD. Such diets are composed of the cells of living organisms, while Western grains, flour and sugar are dense, acellular powders. Bacterial inflammation of the small intestine and vagal afferents appears a crucial step in leptin-resistance and obesity. Therefore it may be important that the Western diet resembles a bacterial growth medium.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Bribiescas RG, Hickey MS. Population variation and differences in serum leptin independent of adiposity: a comparison of Ache Amerindian men of Paraguay and lean American male distance runners. Nutr Metab (Lond). 2006;3:34.

    Article  Google Scholar 

  2. Lindgarde F, Widen I, Gebb M, Ahren B. Traditional versus agricultural lifestyle among Shuar women of the Ecuadorian Amazon: effects on leptin levels. Metabolism. 2004;53(10):1355–8.

    Article  PubMed  CAS  Google Scholar 

  3. Lindeberg S, Lundh B. Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in Kitava. J Intern Med. 1993;233(3):269–75.

    Article  PubMed  CAS  Google Scholar 

  4. Lindeberg S, Eliasson M, Lindahl B, Ahren B. Low serum insulin in traditional Pacific Islanders–the Kitava study. Metabolism. 1999;48(10):1216–9.

    Article  PubMed  CAS  Google Scholar 

  5. Lindeberg S, Nilsson-Ehle P, Terent A, Vessby B, Schersten B. Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study. J Intern Med. 1994;236(3):331–40.

    Article  PubMed  CAS  Google Scholar 

  6. Lindeberg S, Soderberg S, Ahren B, Olsson T. Large differences in serum leptin levels between nonwesternized and westernized populations: the Kitava study. J Intern Med. 2001;249(6):553–8.

    Article  PubMed  CAS  Google Scholar 

  7. Zimmet PZ, McCarty DJ, de Court. The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome. J Diabetes Complicat. 1997;11(2):60–8.

    Article  PubMed  CAS  Google Scholar 

  8. Diamond J. The double puzzle of diabetes. Nature. 2003;423(6940):599–602.

    Article  PubMed  CAS  Google Scholar 

  9. Schaefer O. Medical observations and problems in the Canadian Arctic. II. Can Med Assoc J. 1959;81:386–93.

    PubMed  CAS  Google Scholar 

  10. Bjerregaard P, Young TK, Hegele RA. Low incidence of cardiovascular disease among the Inuit–what is the evidence? Atherosclerosis. 2003;166(2):351–7.

    Article  PubMed  CAS  Google Scholar 

  11. World Health Organization. World Health Statistics 2012. Geneva: WHO Press; 2012. 11-11-2012. Ref Type: Report.

    Google Scholar 

  12. Szostak J, Laurant P. The forgotten face of regular physical exercise: a 'natural' anti-atherogenic activity. Clin Sci (Lond). 2011;121(3):91–106.

    Article  Google Scholar 

  13. Lee IM, Paffenbarger Jr RS, Hennekens CH. Physical activity, physical fitness and longevity. Aging (Milano). 1997;9(1–2):2–11.

    CAS  Google Scholar 

  14. Sesso HD, Paffenbarger Jr RS, Lee IM. Physical activity and coronary heart disease in men: The Harvard Alumni Health Study. Circulation. 2000;102(9):975–80.

    Article  PubMed  CAS  Google Scholar 

  15. Thompson PD, Buchner D, Pina IL, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107(24):3109–16.

    Article  PubMed  Google Scholar 

  16. Pontzer H, Raichlen DA, Wood BM, Mabulla AZ, Racette SB, Marlowe FW. Hunter-gatherer energetics and human obesity. PLoS One. 2012;7(7):e40503.

    Article  PubMed  CAS  Google Scholar 

  17. Mekary RA, Feskanich D, Hu FB, Willett WC, Field AE. Physical activity in relation to long-term weight maintenance after intentional weight loss in premenopausal women. Obesity (Silver Spring). 2010;18(1):167–74.

    Article  Google Scholar 

  18. Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982;248(12):1465–77. doi:10.1001/jama.1982.03330120023025.

  19. • Hooper L, Summerbell CD, Thompson R, et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst Rev. 2012;5:CD002137. A recent Cochrane review of clinical trials on the effects of modifying dietary fat type and intake on cardiovascular disease. Replacing saturated fat with other fats appeared to bring a small (14 %) reduction in cardiovascular events, but there were no benefits of replacement with starches, and no effects on cardiovascular or overall mortality.

    PubMed  Google Scholar 

  20. Howard BV, Van HL, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295(6):655–66.

    Article  PubMed  CAS  Google Scholar 

  21. Lagiou P, Sandin S, Lof M, Trichopoulos D, Adami HO, Weiderpass E. Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study. BMJ. 2012;344:e4026.

    Article  PubMed  Google Scholar 

  22. Sjogren P, Becker W, Warensjo E, et al. Mediterranean and carbohydrate-restricted diets and mortality among elderly men: a cohort study in Sweden. Am J Clin Nutr. 2010;92(4):967–74.

    Article  PubMed  Google Scholar 

  23. Redman LM, Heilbronn LK, Martin CK, et al. Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One. 2009;4(2):e4377.

    Article  PubMed  Google Scholar 

  24. • Gautron L, Elmquist JK. Sixteen years and counting: an update on leptin in energy balance. J Clin Invest. 2011;121(6):2087–93. This is a recent detailed overview of the pathways, cellular and molecular mechanisms involved in leptin signaling, and what is understood about its role in energy regulation and obesity.

    Article  PubMed  CAS  Google Scholar 

  25. Myers Jr MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643–51.

    Article  PubMed  CAS  Google Scholar 

  26. Reed AS, Unger EK, Olofsson LE, Piper ML, Myers Jr MG, Xu AW. Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes. 2010;59(4):894–906.

    Article  PubMed  CAS  Google Scholar 

  27. Rajan A, Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell. 2012;151(1):123–37.

    Article  PubMed  CAS  Google Scholar 

  28. Berthoud HR, Zheng H, Shin AC. Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery. Ann N Y Acad Sci. 2012;1264(1):36–48.

    Article  PubMed  CAS  Google Scholar 

  29. Yamazaki Y, Emoto M, Morioka T et al. Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes. J Atheroscler Thromb. 2012.

  30. Kantorova E, Chomova M, Kurca E, et al. Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke. Neuroendocrinol Lett. 2011;32(5):716–21.

    PubMed  CAS  Google Scholar 

  31. Lam V, Su J, Koprowski S et al. Intestinal microbiota determine severity of myocardial infarction in rats. FASEB J. 2012;26(4):1727–35. doi:10.1096/fj.11-197921.

    Google Scholar 

  32. Page LB, Damon A, Moellering Jr RC. Antecedents of cardiovascular disease in six Solomon Islands societies. Circulation. 1974;49(6):1132–46.

    Article  PubMed  CAS  Google Scholar 

  33. O'Dea K. Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle. Diabetes. 1984;33(6):596–603.

    Article  PubMed  Google Scholar 

  34. •• Jonsson T, Granfeldt Y, Ahren B, et al. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009;8:35. This small randomized cross-over study compared paleolithic and diabetes diets for two consecutive 3 month periods. The paleolithic diet was found to improve glycemic control, HbA1c, triacylglycerol, diastolic blood pressure, waist circumference and weight significantly better than the diabetes diet.

    Article  PubMed  Google Scholar 

  35. Osterdahl M, Kocturk T, Koochek A, Wandell PE. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr. 2008;62(5):682–5.

    Article  PubMed  CAS  Google Scholar 

  36. Lindeberg S, Jonsson T, Granfeldt Y, et al. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia. 2007;50(9):1795–807.

    Article  PubMed  CAS  Google Scholar 

  37. •• Jonsson T, Granfeldt Y, Erlanson-Albertsson C, Ahren B, Lindeberg S. A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab (Lond). 2010;7:85. A detailed analysis of the factors behind the spontaneously decreased caloric intake seen in the paleolithic diet group during a 12 week randomized controlled dietary intervention, compared with a 'Mediterranean' diet, in 20 male ischemic heart disease patients. Both groups were equally satiated, but the paleolithic group required 23 % fewer calories, and had a 31 % drop in leptin, which correlated with waist reduction in only the paleolithic group.

    Article  Google Scholar 

  38. • Frassetto LA, Schloetter M, Mietus-Synder M, Morris Jr RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009;63(8):947–55. A small human dietary experiment (9 subjects, without a control group) designed to resolve whether hunter-gatherer-like diet requires weightloss for beneficial effects. Despite the healthy status of the subjects, caloric intake being fixed, the study's small size and its short 10 day timespan, substantial improvements in circulatory, carbohydrate, lipid and metabolic markers were seen, with improvements in every participant for most markers.

    Article  PubMed  CAS  Google Scholar 

  39. •• Lindeberg S. Food and western disease; health and nutrition from an evolutionary perspective. Oxford: Wiley-Blackwell; 2010. The definitive and detailed guide to the effects of Western lifestyle upon human health. A well-balanced, highly readable review of the available data. Required reading for both clinicians and policy-makers.

    Google Scholar 

  40. Danby FW. Nutrition and acne. Clin Dermatol. 2010;28(6):598–604.

    Article  PubMed  Google Scholar 

  41. Hoppe C, Molgaard C, Dalum C, Vaag A, Michaelsen KF. Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. Eur J Clin Nutr. 2009;63(9):1076–83.

    Article  PubMed  CAS  Google Scholar 

  42. Struijk EA, Heraclides A, Witte DR et al. Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. Nutr Metab Cardiovasc Dis. 2012. doi:10.1016/j.numecd.2012.05.011.

  43. Warensjo E, Jansson JH, Cederholm T, et al. Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am J Clin Nutr. 2010;92(1):194–202.

    Article  PubMed  Google Scholar 

  44. Biss K, Ho KJ, Mikkelson B, Lewis L, Taylor CB. Some unique biologic characteristics of the Masai of East Africa. N Engl J Med. 1971;284(13):694–9.

    Article  PubMed  CAS  Google Scholar 

  45. Mann GV. The Masai, milk and the yogurt factor: an alternative explanation. Atherosclerosis. 1978;29(2):265.

    Article  PubMed  CAS  Google Scholar 

  46. Boeing H, Bechthold A, Bub A, et al. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr. 2012;51(6):637–63.

    Article  PubMed  CAS  Google Scholar 

  47. Bruckdorfer KR. Antioxidants and CVD. Proc Nutr Soc. 2008;67(2):214–22.

    Article  PubMed  CAS  Google Scholar 

  48. Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. N Engl J Med. 2006;354(15):1601–13.

    Article  PubMed  CAS  Google Scholar 

  49. Simopoulos AP. Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins Leukot Essent Fat Acids. 1999;60(5–6):421–9.

    Article  CAS  Google Scholar 

  50. Baum SJ, Kris-Etherton PM, Willett WC, et al. Fatty acids in cardiovascular health and disease: a comprehensive update. J Clin Lipidol. 2012;6(3):216–34.

    Article  PubMed  Google Scholar 

  51. Harris WS, Mozaffarian D, Rimm E, et al. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation. 2009;119(6):902–7.

    Article  PubMed  Google Scholar 

  52. Hooper L, Harrison RA, Summerbell CD, Moore H, Worthington HV, Ness A, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. 2004;(4):CD003177. doi:10.1002/14651858.CD003177.pub2.

  53. Jorgensen ME, Bjerregaard P, Kjaergaard JJ, Borch-Johnsen K. High prevalence of markers of coronary heart disease among Greenland Inuit. Atherosclerosis. 2008;196(2):772–8.

    Article  PubMed  CAS  Google Scholar 

  54. Alvheim AR, Malde MK, Osei-Hyiaman D, et al. Dietary Linoleic acid elevates endogenous 2-AG and Anandamide and induces obesity. Obesity (Silver Spring). 2012;20(10):1984–94.

    Article  CAS  Google Scholar 

  55. Strohle A, Hahn A. Diets of modern hunter-gatherers vary substantially in their carbohydrate content depending on ecoenvironments: results from an ethnographic analysis. Nutr Res. 2011;31(6):429–35.

    Article  PubMed  Google Scholar 

  56. Cordain L, Eaton SB, Miller JB, Mann N, Hill K. The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic. Eur J Clin Nutr. 2002;56 Suppl 1:S42–52.

    Article  PubMed  Google Scholar 

  57. Lindeberg S, Berntorp E, Nilsson-Ehle P, Terent A, Vessby B. Age relations of cardiovascular risk factors in a traditional Melanesian society: the Kitava Study. Am J Clin Nutr. 1997;66(4):845–52.

    PubMed  CAS  Google Scholar 

  58. Zienczuk N, Young TK, Cao ZR, Egeland GM. Dietary correlates of an at-risk BMI among Inuit adults in the Canadian high arctic: cross-sectional international polar year Inuit health survey, 2007-2008. Nutr J. 2012;11(1):73.

    Article  PubMed  CAS  Google Scholar 

  59. Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007;297(9):969–77.

    Article  PubMed  CAS  Google Scholar 

  60. Brinkworth GD, Noakes M, Buckley JD, Keogh JB, Clifton PM. Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am J Clin Nutr. 2009;90(1):23–32.

    Article  PubMed  CAS  Google Scholar 

  61. Pawlak DB, Kushner JA, Ludwig DS. Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet. 2004;364(9436):778–85.

    Article  PubMed  CAS  Google Scholar 

  62. •• Ebbeling CB, Swain JF, Feldman HA, et al. Effects of dietary composition on energy expenditure during weight-loss maintenance. JAMA. 2012;307(24):2627–34. Groundbreaking small clinical trial demonstrating altered energy expenditure after weightloss, depending on carbohydrate content and nature of isocaloric diets. Low-fat diets prompted the lowest energy expenditure (i.e., largest drive to regain weight), low-glycemic index diet was intermediate, with low-carbohydrate diet producing the most unaffected energy expenditure.

    Article  PubMed  CAS  Google Scholar 

  63. Thornley S, Tayler R, Sikaris K. Sugar restriction: the evidence for a drug-free intervention to reduce cardiovascular disease risk. Intern Med J. 2012;42 Suppl 5:46–58.

    Article  PubMed  Google Scholar 

  64. Lustig RH, Schmidt LA, Brindis CD. Public health: the toxic truth about sugar. Nature. 2012;482(7383):27–9.

    Article  PubMed  CAS  Google Scholar 

  65. Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 2010;33(11):2477–83.

    Article  PubMed  Google Scholar 

  66. Holt SH, Miller JC, Petocz P. An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods. Am J Clin Nutr. 1997;66(5):1264–76.

    PubMed  CAS  Google Scholar 

  67. Foster-Powell K, Holt SHA, Brand-Miller JC. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002;76(1):5–56.

    PubMed  CAS  Google Scholar 

  68. Lindeberg S, Ahren B, Nilsson A, Cordain L, Nilsson-Ehle P, Vessby B. Determinants of serum triglycerides and high-density lipoprotein cholesterol in traditional Trobriand Islanders: the Kitava Study. Scand J Clin Lab Invest. 2003;63(3):175–80.

    PubMed  CAS  Google Scholar 

  69. Cleave TL. The Saccharine Disease. Conditions caused by the taking of refined carbohydrates such as sugar and white flour. Bristol: Wright; 1974.

    Google Scholar 

  70. Wanders AJ, van den Borne JJ. de GC et al. Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials. Obes Rev. 2011;12(9):724–39.

    PubMed  CAS  Google Scholar 

  71. Williams PG. Evaluation of the evidence between consumption of refined grains and health outcomes. Nutr Rev. 2012;70(2):80–99.

    Article  PubMed  Google Scholar 

  72. Jonsson T, Olsson S, Ahren B, Bog-Hansen TC, Dole A, Lindeberg S. Agrarian diet and diseases of affluence–do evolutionary novel dietary lectins cause leptin resistance? BMC Endocr Disord. 2005;5:10.

    Article  PubMed  Google Scholar 

  73. Gurven M, Kaplan H, Winking J, et al. Inflammation and infection do not promote arterial aging and cardiovascular disease risk factors among lean horticulturalists. PLoS One. 2009;4(8):e6590.

    Article  PubMed  Google Scholar 

  74. Koopman JJ, van Bodegom D, Jukema JW, Westendorp RG. Risk of cardiovascular disease in a traditional african population with a high infectious load: a population-based study. PLoS One. 2012;7(10):e46855.

    Article  PubMed  CAS  Google Scholar 

  75. • Musso G, Gambino R, Cassader M. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med. 2011;62:361–80. A comprehensive overview of research into the gastrointestinal microbiota, and some of the possible mechanisms by which they may affect obesity and diabetes.

    Article  PubMed  CAS  Google Scholar 

  76. Rabot S, Membrez M, Bruneau A, et al. Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010;24(12):4948–59.

    Article  PubMed  CAS  Google Scholar 

  77. Caesar R, Reigstad CS, Backhed HK et al. Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut. 2012;61(12):1701–7. doi:10.1136/gutjnl-2011-301689.

    Google Scholar 

  78. Vrieze A, Van NE, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913–6.

    Article  PubMed  CAS  Google Scholar 

  79. Ridley EV, Wong AC, Westmiller S, Douglas AE. Impact of the resident microbiota on the nutritional phenotype of Drosophila melanogaster. PLoS One. 2012;7(5):e36765.

    Article  PubMed  CAS  Google Scholar 

  80. Shin SC, Kim SH, You H, et al. Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. Science. 2011;334(6056):670–4.

    Article  PubMed  CAS  Google Scholar 

  81. Apolzan JW, Harris RB. Rapid onset and reversal of peripheral and central leptin resistance in rats offered chow, sucrose solution, and lard. Appetite. 2013;60(1):65–73. doi:10.1016/j.appet.2012.09.020.

  82. •• Ding S, Chi MM, Scull BP, et al. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One. 2010;5(8):e12191. First demonstration that bacterial-dependent small intestinal inflammation (TNF-alpha and NF-kappaB) precedes diet-induced obesity in mice, and correlates well with that subsequent obesity. Potentially a crucial discovery.

    Article  PubMed  Google Scholar 

  83. •• de La Serre CB, Ellis CL, Lee J, Hartman AL, Rutledge JC, Raybould HE. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol. 2010;299(2):G440–8. Rat dietary experiments showing small intestinal inflammatory, gut permeability and certain microbiota changes occurring only in diet-induce obesity prone animals, not their lean obesity-resistant littermates. Part of the recent line of evidence implicating small intestinal microbiota in obesity.

    Article  Google Scholar 

  84. •• de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould HA. Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. Am J Physiol Endocrinol Metab. 2011;301(1):E187–95. doi:10.1152/ajpendo.00056.2011. Rat dietary study showing peripheral leptin-resistance in the vagal afferents of diet-induced obese rats, but not resistant littermates or controls. SOCS3 may be involved, and a possible bacterial mechanism via LPS is demonstrated. Subsequent work by this group showed this could markedly affect the sensitivity of the vagal afferents to satiety signals.

  85. Mancuso P, Myers Jr MG, Goel D, et al. Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia. J Immunol. 2012;189(2):867–75.

    Article  PubMed  CAS  Google Scholar 

  86. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010;107(33):14691–6.

    Article  PubMed  Google Scholar 

  87. Nasidze I, Li J, Schroeder R, Creasey JL, Li M, Stoneking M. High diversity of the saliva microbiome in Batwa Pygmies. PLoS One. 2011;6(8):e23352.

    Article  PubMed  CAS  Google Scholar 

  88. Dewulf EM, Cani PD, Claus SP et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut. 2012. doi:10.1136/gutjnl-2012-303304.

  89. Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010;64(6):636–43.

    Article  PubMed  CAS  Google Scholar 

  90. •• Spreadbury I. Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity. Diabetes Metab Syndr Obes. 2012;5:175–89. Hypothesis suggesting that grains and processed foods might affect small intestinal bacteria and inflammation differently to cellular foods, and hence underlie Western obesity and metabolic dysregulation. If correct, this would explain many paradoxes, and provide a rationale for novel dietary advice.

    Article  PubMed  CAS  Google Scholar 

  91. NDL/FNIC Food Composition Database. Agricultural Research Service National Agricultural Library. 2012. 2012. Ref Type: Internet Communication

  92. Abramovitch RB, Anderson JC, Martin GB. Bacterial elicitation and evasion of plant innate immunity. Nat Rev Mol Cell Biol. 2006;7(8):601–11.

    Article  PubMed  CAS  Google Scholar 

  93. Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr. 2004;79(5):774–9.

    PubMed  CAS  Google Scholar 

  94. • Hujoel P. Dietary carbohydrates and dental-systemic diseases. J Dent Res. 2009;88(6):490–502. A far-reaching review of the link between dietary carbohydrates, dental disease, cardiovascular risk factors, and the changes in each over time.

    Article  PubMed  CAS  Google Scholar 

  95. Baumgartner S, Imfeld T, Schicht O, Rath C, Persson RE, Persson GR. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol. 2009;80(5):759–68.

    Article  PubMed  Google Scholar 

  96. Lockhart PB, Bolger AF, Papapanou PN et al. Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?: A Scientific Statement From the American Heart Association. Circulation. 2012;125(20):2520–44. doi:10.1161/CIR.0b013e31825719f3.

    Google Scholar 

  97. •• Desmarchelier C, Ludwig T, Scheundel R et al. Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition. Br J Nutr. 2012;1–10. doi:10.1017/S0007114512003340. A potentially pivotal rodent dietary study showing that powdered foods (even control chows) produce equivalent caloric intake, weight gain and leptin levels in a macronutrient-independent manner. Undermines previous conclusions regarding macronutrients obtained from such models. The data appear consistent with energy homeostasis being perturbed by a small-intestinal lumen-based sensor that is heavily influenced by nutrients in powdered form.

  98. Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479(7374):538–41.

    Article  PubMed  CAS  Google Scholar 

  99. Bumaschny VF, Yamashita M, Casas-Cordero R, et al. Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest. 2012;122(11):4203–12.

    Article  PubMed  CAS  Google Scholar 

  100. Lindeberg S. Paleolithic diets as a model for prevention and treatment of Western disease. Am J Hum Biol. 2012;24(2):110–5.

    Article  PubMed  Google Scholar 

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Spreadbury, I., Samis, A.J.W. Evolutionary Aspects of Obesity, Insulin Resistance, and Cardiovascular Risk. Curr Cardiovasc Risk Rep 7, 136–146 (2013). https://doi.org/10.1007/s12170-013-0293-1

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