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The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients

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Abstract

Introduction

The cannabinoid receptor gene 1 (CNR1) encodes the human cannabinoid receptor CB1. This receptor has a widespread distribution in the central nervous system (CNS), the main ligands being anandamide, 2-araquidonoil glycerol and marijuana constituents. There is evidence to suggest an anti-neoplastic effect of these ligands in glial tissues mediated through stimulation of the receptor.

Material and methods

We have studied the G1359A polymorphism of the gene CNR1 with a TaqMan allelic discrimination assay in 200 patients diagnosed with glioma, 109 patients diagnosed with meningioma and 403 healthy subjects.

Results

Genotypic distribution of the G1359A CNR1 polymorphism in glioma patients showed significant differences when compared to the control group.

Discussion

Our results suggest that allele G of the CNR1 gene could be associated with a lower susceptibility to glioma.

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Authors and Affiliations

  1. Cancer Research Center-IBMCC, University of Salamanca-CSIC, Campus Miguel de Unamuno, ES-37007, Salamanca, Spain

    Mercedes Núñez, Sandra Perdomo & Rogelio González-Sarmiento

  2. Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain

    Mercedes Núñez, Sandra Perdomo & Rogelio González-Sarmiento

  3. Department of Neurosurgery, University Hospital, Salamanca, Spain

    Juan Moreta

  4. Department of Pathology, University Hospital, Salamanca, Spain

    Ángel Santos-Briz

Authors
  1. Mercedes Núñez
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  2. Sandra Perdomo
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  3. Juan Moreta
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  4. Ángel Santos-Briz
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  5. Rogelio González-Sarmiento
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Correspondence to Rogelio González-Sarmiento.

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Núñez, M., Perdomo, S., Moreta, J. et al. The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients. Clin Transl Oncol 12, 825–828 (2010). https://doi.org/10.1007/s12094-010-0604-7

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  • DOI: https://doi.org/10.1007/s12094-010-0604-7

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