Medical Oncology

, Volume 27, Issue 2, pp 430–433

Gemcitabine and lenalidomide combination in a patient with metastatic pancreatic cancer: a case study

Original Paper

DOI: 10.1007/s12032-009-9228-6

Cite this article as:
Liu, W.M., Nizar, S. & Dalgleish, A.G. Med Oncol (2010) 27: 430. doi:10.1007/s12032-009-9228-6

Abstract

The proportion of people surviving pancreatic cancer is extremely low, with just 10% of patients diagnosed with any stage of the disease living beyond 1 year and a 5-year relative survival rate of <5%. The lack of effective therapy is one the main reason for such a bleak outlook. Herein, we report on a patient with pancreatic adenocarcinoma and metastatic disease treated with a combination regimen of gemcitabine and lenalidomide, without major complications. We also present in vitro data that highlight a hyper-additive effect of the two drugs when used in combination. To date, 33 months after diagnosis, the patient remains well and continues in full-time employment.

Keywords

Pancreatic cancerDrug combination therapyGemcitabineLenalidomide

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  1. 1.Department of Oncology, Division of Cellular and Molecular MedicineSt. George’s University of LondonLondonUK