Skip to main content

Advertisement

Log in

Association between vitamin D and sperm parameters: Clinical evidence

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. M. Blomberg Jensen, Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 144, 135–152 (2012)

    Article  PubMed  Google Scholar 

  2. J. Merke, W. Kreusser, B. Bier, E. Ritz, Demonstration and characterisation of a testicular receptor for 1,25-dihydroxycholecalciferol in the rat. Eur. J. Biochem. 130, 303–308 (1983)

    Article  CAS  PubMed  Google Scholar 

  3. G.G. Kwiecinski, G.I. Petrie, H.F. DeLuca, Vitamin D is necessary for reproductive functions of the male rat. J. Nutr. 119, 741–744 (1989)

    CAS  PubMed  Google Scholar 

  4. A.O. Hammoud, A.W. Meikle, C.M. Peterson, J. Stanford, M. Gibson, D.T. Carrell, Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J. Androl. 14, 855–859 (2012)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. M. Blomberg Jensen, A. Jørgensen, J.E. Nielsen, P.J. Bjerrum, M. Skalkam, J.H. Petersen, D.L. Egeberg, S. Bangsbøll, A.N. Andersen, N.E. Skakkebaek, A. Juul, E. Rajpert-De Meyts, S. Dissing, H. Leffers, N. Jørgensen, Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int. J. Androl. 35, 499–510 (2012)

    Article  CAS  PubMed  Google Scholar 

  6. B. Yang, H. Sun, Y. Wan, H. Wang, W. Qin, L. Yang, H. Zhao, J. Yuan, B. Yao, Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int. J. Androl. 35, 783–792 (2012)

    Article  CAS  PubMed  Google Scholar 

  7. M. Tartagni, M. Matteo, D. Baldini, M.V. Tartagni, H. Alrasheed, M.A. De Salvia, G. Loverro, M. Montagnani, Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study. Reprod. Biol. Endocrinol. 13, 127 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  8. M. Blomberg Jensen, P.J. Bjerrum, T.E. Jessen, J.E. Nielsen, U.N. Joensen, I.A. Olesen, J.H. Petersen, A. Juul, S. Dissing, N. Jørgensen, Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum. Reprod. 26, 1307–1317 (2011)

    Article  CAS  PubMed  Google Scholar 

  9. C.L. Zhu, Q.F. Xu, S.X. Li, Y.C. Wei, G.C. Zhu, C. Yang, Y.C. Shi, Investigation of serum vitamin D levels in Chinese infertile men. Andrologia (2016). 10.1111/and.12570

  10. C.H. Ramlau-Hansen, U.K. Moeller, J.P. Bonde, J. Olsen, A.M. Thulstrup, Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil. Steril. 95, 1000–1004 (2011)

    Article  CAS  PubMed  Google Scholar 

  11. J. Sonnenberg, V.N. Luine, L.C. Krey, S. Christakos, 1,25-Dihydroxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nuclei. Endocrinology 118, 1433–1439 (1986)

    Article  CAS  PubMed  Google Scholar 

  12. A. Vermeulen, L. Verdonck, J.M. Kaufman, A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84, 3666–3672 (1999)

    Article  CAS  PubMed  Google Scholar 

  13. World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th edn. World Health Organization, Geneva, (2010)

    Google Scholar 

  14. S. Holm, A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6, 65–70 (1979)

    Google Scholar 

  15. J.A. Johnson, J.P. Grande, P.C. Roche, R. Kumar, Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem. Cell. Biol. 105, 7–15 (1996)

    Article  CAS  PubMed  Google Scholar 

  16. J. Merke, U. Hügel, E. Ritz, Nuclear testicular 1,25-dihydroxyvitamin D3 receptors in Sertoli cells and seminiferous tubules of adult rodents. Biochem. Biophys. Res. Commun. 127, 303–309 (1985)

    Article  CAS  PubMed  Google Scholar 

  17. E. Lerchbaum, B. Obermayer-Pietsch, Vitamin D and fertility: a systematic review. Eur. J. Endocrinol. 166, 765–778 (2012)

    Article  CAS  PubMed  Google Scholar 

  18. Y. Huang, H. Jin, J. Chen, X. Jiang, P. Li, Y. Ren, W. Liu, J. Yao, J.K. Folger, G.W. Smith, L. Lv, Effect of vitamin D on basal and luteinizing hormone (LH) induced testosterone production and mitochondrial dehydrogenase activity in cultured leydig cells from immature and mature rams. Anim. Reprod. Sci. 158, 109–114 (2015)

    Article  CAS  PubMed  Google Scholar 

  19. S. Pilz, S. Frisch, H. Koertke, J. Kuhn, J. Dreier, B. Obermayer-Pietsch, E. Wehr, A. Zittermann, Effect of vitamin D supplementation on testosterone levels in men. Horm. Metab. Res. 43, 223–225 (2011)

    Article  CAS  PubMed  Google Scholar 

  20. R. Jorde, G. Grimnes, M.S. Hutchinson, M. Kjærgaard, E. Kamycheva, J. Svartberg, Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Horm. Metab. Res. 45, 675–681 (2013)

    Article  CAS  PubMed  Google Scholar 

  21. A.C. Heijboer, M. Oosterwerff, N.F. Schroten, E.M. Eekhoff, V.G. Chel, R.A. de Boer, M.A. Blankenstein, P. Lips, Vitamin D supplementation and testosterone concentrations in male human subjects. Clin. Endocrinol. 83, 105–110 (2015)

    Article  CAS  Google Scholar 

Download references

Funding

No external funding, apart from the support of the Polytechnic University of Marche, was available for this study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giancarlo Balercia.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tirabassi, G., Cutini, M., Muscogiuri, G. et al. Association between vitamin D and sperm parameters: Clinical evidence. Endocrine 58, 194–198 (2017). https://doi.org/10.1007/s12020-016-1198-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-016-1198-9

Keywords

Navigation