Abstract
Proton pump inhibitors (PPIs) are a commonly prescribed class of medications. Their use has been associated with an increased rate of fractures, most notably hip fractures. However, there does not seem to be a clear association between PPI use and bone mineral density measurements, assessed by dual X-ray absorptiometry. The mechanism by which PPI use increases the risk of fractures remains unclear. This review will summarize the current evidence on this topic.
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Conflict of interest
Arthur Lau: Honorariums/Consultations: Amgen, Abbvie, Roche, UCB, Celgene; Stocks: None to declare. Jonathan D. Adachi: Honorariums/Consultations: Amgen, Merck Frost Canada, Eli Lilly, Warner Chilcott; Stocks: None to declare. Michael Tomizza: None to declare. Matthew Wong Pack: None to declare. Alexandra Papaioannou: Honorariums/Consultations: Amgen, Merck Frost Canada, Eli Lilly, Warner Chilcott, Novartis.
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Lau, A.N., Tomizza, M., Wong-Pack, M. et al. The relationship between long-term proton pump inhibitor therapy and skeletal frailty. Endocrine 49, 606–610 (2015). https://doi.org/10.1007/s12020-015-0576-z
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DOI: https://doi.org/10.1007/s12020-015-0576-z