Obesity Surgery

, 18:841

Safety and Effectiveness of the Intragastric Balloon for Obesity. A Meta-Analysis

  • Iñaki Imaz
  • Carmen Martínez-Cervell
  • Elvira Elena García-Álvarez
  • Juan Manuel Sendra-Gutiérrez
  • Jesús González-Enríquez
Research Article

DOI: 10.1007/s11695-007-9331-8

Cite this article as:
Imaz, I., Martínez-Cervell, C., García-Álvarez, E.E. et al. OBES SURG (2008) 18: 841. doi:10.1007/s11695-007-9331-8

Abstract

Background

Intragastric balloons have been used since 1985 to treat obesity, but an evidence-based systematic review had not been previously performed. The objective of this study is to determine the safety, efficacy, and effectiveness of the most widely used balloon, BioEnterics Intragastric Balloon (BIB®), to treat obesity.

Methods

Systematic literature review of Medline, Embase, and other information sources from inception to March 2006. The quality of selected studies was assessed. Meta-analysis of weighted mean difference was made using the inverse variance method.

Results

We pooled 15 articles (3,608 patients) to estimate BIBs® effectiveness. The estimates for weight lost at balloon removal for BIB® were the following: 14.7 kg, 12.2% of initial weight, 5.7 kg/m2, and 32.1% of excess weight. However, data were scant after balloon removal. Yet, efficacy at balloon removal was estimated with a meta-analysis of two randomized controlled trials (75 patients) that compared balloon versus placebo, indicating the balloon group lost more weight than the placebo group. These differences in weight lost were 6.7 kg, 1.5% of initial weight, 3.2 kg/m2, and 17.6% of excess weight. Regarding BIB® safety, the majority of complications were mild and the early removal rate was 4.2%.

Conclusion

The use of the BIB®, within a multidisciplinary weight management program, is a short-term effective treatment to lose weight, but it is not yet possible to verify its capacity to maintain the weight lost over a long period of time.

Keywords

Intragastric balloonBIBObesityMeta-analysisSystematic review

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Iñaki Imaz
    • 1
  • Carmen Martínez-Cervell
    • 2
  • Elvira Elena García-Álvarez
    • 3
  • Juan Manuel Sendra-Gutiérrez
    • 1
  • Jesús González-Enríquez
    • 1
  1. 1.Agencia de Evaluación de Tecnologías Sanitarias, Instituto de Salud “Carlos III”Ministry of Health and Consumer AffairsMadridSpain
  2. 2.Preventative Medicine DepartmentHospital Clínico “San Carlos”, Health Service of MadridMadridSpain
  3. 3.Evidence-Based Medicine DepartmentHealth Sciences Institute of AragonAragonSpain