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Tolerance and Efficacy of an Air-filled Balloon in Non-morbidly Obese Patients: Results of a Prospective Multicenter Study

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Background

Intragastric balloons have been proposed to induce body weight loss in obese subjects. Most studies were performed using liquid-filled balloons. Air-filled balloons may increase digestive tolerance. Our goal was to study the tolerance and efficacy of a new air-filled intragastric balloon in nonmorbidly obese patients.

Methods

32 patients were included, with a mean BMI of 35.0 (range 30.1–40.0). The balloon was inserted under general anaesthesia, inflated with 800 ml of air, and removed 4 months later. Tolerance and body weight were monitored until 12 months after removal. Ghrelin levels were measured before balloon insertion, 1 and 4 weeks after, and before removal.

Results

Weight loss was significant at 1, 2 and 4 months after balloon insertion (6, 7 and 10 kg, respectively, P < 0.001). Early removal of the balloon occurred in 3 cases. 28 patients were contacted 12 months after balloon removal: 2 had undergone gastric banding; among the 26 remaining, the mean weight loss was 7 kg. 9 patients (30%) remained with a weight loss > 10%, and satisfaction with the method was 87% for these 9 patients, and 22% for the other patients who had weight loss < 10% (P < 0.04). Fasting plasma ghrelin levels increased at week 1 and 4 after balloon insertion, and decreased at week 16 (P < 0.001).

Conclusions

The air-filled intragastric balloon was safe. Its effect on weight loss appeared equivalent to other balloons. 12 months after balloon removal, 30% of the patients maintained a weight loss > 10%.

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Authors and Affiliations

  1. Hospices Civils de Lyon, Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France

    François Mion, Rodica Gincul, Sabine Roman & Frédérique Trepo

  2. Université Claude Bernard Lyon 1, Lyon, France

    François Mion & Sabine Roman

  3. Clinique Sauvegarde, Lyon, France

    Sylvain Beorchia

  4. Clinique Pasteur, St Priest, France

    Frank Hedelius

  5. Polyclinique du Beaujolais, Arnas, France

    Nicolas Claudel

  6. Clinique Ste Anne-Lumière, Lyon, France

    Roger-Michel Bory & Bertrand Napoleon

  7. Fédération de Biochimie, Hôpital E. Herriot, Lyon, France

    Etienne Malvoisin

  8. Fédération des Spécialités Digestives, Hôpital E. Herriot, 69437, Lyon cedex 03, France

    François Mion

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  1. François Mion
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  2. Rodica Gincul
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  3. Sabine Roman
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  4. Sylvain Beorchia
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  5. Frank Hedelius
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  6. Nicolas Claudel
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  7. Roger-Michel Bory
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  8. Etienne Malvoisin
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  9. Frédérique Trepo
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  10. Bertrand Napoleon
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Correspondence to François Mion.

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Mion, F., Gincul, R., Roman, S. et al. Tolerance and Efficacy of an Air-filled Balloon in Non-morbidly Obese Patients: Results of a Prospective Multicenter Study. OBES SURG 17, 764–769 (2007). https://doi.org/10.1007/s11695-007-9141-z

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  • DOI: https://doi.org/10.1007/s11695-007-9141-z

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