Journal of Gastrointestinal Surgery

, Volume 18, Issue 10, pp 1795–1803

Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus

  • Brennan M. R. Spiegel
  • Marc Kaneshiro
  • Marcia M. Russell
  • Anne Lin
  • Anish Patel
  • Vartan C. Tashjian
  • Vincent Zegarski
  • Digvijay Singh
  • Samuel E. Cohen
  • Mark W. Reid
  • Cynthia B. Whitman
  • Jennifer Talley
  • Bibiana M. Martinez
  • William Kaiser
Original Article

DOI: 10.1007/s11605-014-2597-y

Cite this article as:
Spiegel, B.M.R., Kaneshiro, M., Russell, M.M. et al. J Gastrointest Surg (2014) 18: 1795. doi:10.1007/s11605-014-2597-y

Abstract

Background

Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.

Study Design

AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.

Results

There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).

Conclusion

Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.

Keywords

Postoperative IleusBiosensorHealth technology

Copyright information

© The Society for Surgery of the Alimentary Tract 2014

Authors and Affiliations

  • Brennan M. R. Spiegel
    • 2
    • 5
    • 6
    • 7
    • 8
    • 9
  • Marc Kaneshiro
    • 2
    • 5
  • Marcia M. Russell
    • 1
    • 4
  • Anne Lin
    • 4
  • Anish Patel
    • 2
    • 6
  • Vartan C. Tashjian
    • 5
  • Vincent Zegarski
    • 3
  • Digvijay Singh
    • 3
  • Samuel E. Cohen
    • 2
    • 6
  • Mark W. Reid
    • 2
    • 8
  • Cynthia B. Whitman
    • 8
  • Jennifer Talley
    • 2
    • 8
  • Bibiana M. Martinez
    • 8
  • William Kaiser
    • 3
    • 10
  1. 1.Department of SurgeryVA Greater Los Angeles Healthcare SystemLos AngelesUSA
  2. 2.Department of MedicineVA Greater Los Angeles Healthcare SystemLos AngelesUSA
  3. 3.UCLA Wireless Health InstituteHenry Samueli School of Engineering and Applied ScienceLos AngelesUSA
  4. 4.Department of SurgeryDavid Geffen School of Medicine at UCLALos AngelesUSA
  5. 5.Department of Medicine, Division of Digestive DiseasesDavid Geffen School of Medicine at UCLALos AngelesUSA
  6. 6.Department of MedicineCedars-Sinai Medical CenterLos AngelesUSA
  7. 7.Department of Health Policy and ManagementUCLA Fielding School of Public HealthLos AngelesUSA
  8. 8.UCLA/VA Center for Outcomes Research and Education (CORE)Los AngelesUSA
  9. 9.Division of GastroenterologyWest Los Angeles VA Medical CenterLos AngelesUSA
  10. 10.Electrical Engineering DepartmentUniversity of California, Los AnglesLos AngelesUSA