Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus
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Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.
AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.
There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).
Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.
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- Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus
Journal of Gastrointestinal Surgery
Volume 18, Issue 10 , pp 1795-1803
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Postoperative Ileus
- Health technology
- Industry Sectors
- Brennan M. R. Spiegel (2) (5) (6) (7) (8) (9)
- Marc Kaneshiro (2) (5)
- Marcia M. Russell (1) (4)
- Anne Lin (4)
- Anish Patel (2) (6)
- Vartan C. Tashjian (5)
- Vincent Zegarski (3)
- Digvijay Singh (3)
- Samuel E. Cohen (2) (6)
- Mark W. Reid (2) (8)
- Cynthia B. Whitman (8)
- Jennifer Talley (2) (8)
- Bibiana M. Martinez (8)
- William Kaiser (10) (3)
- Author Affiliations
- 2. Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, USA
- 5. Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, USA
- 6. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
- 7. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, USA
- 8. UCLA/VA Center for Outcomes Research and Education (CORE), Los Angeles, USA
- 9. Division of Gastroenterology, West Los Angeles VA Medical Center, Los Angeles, USA
- 1. Department of Surgery, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
- 4. Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, USA
- 3. UCLA Wireless Health Institute, Henry Samueli School of Engineering and Applied Science, Los Angeles, USA
- 10. Electrical Engineering Department, University of California, Los Angles, Los Angeles, USA