Journal of Gastrointestinal Surgery

, Volume 18, Issue 10, pp 1795–1803

Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus

Authors

    • Department of MedicineVA Greater Los Angeles Healthcare System
    • Department of Medicine, Division of Digestive DiseasesDavid Geffen School of Medicine at UCLA
    • Department of MedicineCedars-Sinai Medical Center
    • Department of Health Policy and ManagementUCLA Fielding School of Public Health
    • UCLA/VA Center for Outcomes Research and Education (CORE)
    • Division of GastroenterologyWest Los Angeles VA Medical Center
  • Marc Kaneshiro
    • Department of MedicineVA Greater Los Angeles Healthcare System
    • Department of Medicine, Division of Digestive DiseasesDavid Geffen School of Medicine at UCLA
  • Marcia M. Russell
    • Department of SurgeryVA Greater Los Angeles Healthcare System
    • Department of SurgeryDavid Geffen School of Medicine at UCLA
  • Anne Lin
    • Department of SurgeryDavid Geffen School of Medicine at UCLA
  • Anish Patel
    • Department of MedicineVA Greater Los Angeles Healthcare System
    • Department of MedicineCedars-Sinai Medical Center
  • Vartan C. Tashjian
    • Department of Medicine, Division of Digestive DiseasesDavid Geffen School of Medicine at UCLA
  • Vincent Zegarski
    • UCLA Wireless Health InstituteHenry Samueli School of Engineering and Applied Science
  • Digvijay Singh
    • UCLA Wireless Health InstituteHenry Samueli School of Engineering and Applied Science
  • Samuel E. Cohen
    • Department of MedicineVA Greater Los Angeles Healthcare System
    • Department of MedicineCedars-Sinai Medical Center
  • Mark W. Reid
    • Department of MedicineVA Greater Los Angeles Healthcare System
    • UCLA/VA Center for Outcomes Research and Education (CORE)
  • Cynthia B. Whitman
    • UCLA/VA Center for Outcomes Research and Education (CORE)
  • Jennifer Talley
    • Department of MedicineVA Greater Los Angeles Healthcare System
    • UCLA/VA Center for Outcomes Research and Education (CORE)
  • Bibiana M. Martinez
    • UCLA/VA Center for Outcomes Research and Education (CORE)
    • UCLA Wireless Health InstituteHenry Samueli School of Engineering and Applied Science
    • Electrical Engineering DepartmentUniversity of California, Los Angles
Original Article

DOI: 10.1007/s11605-014-2597-y

Cite this article as:
Spiegel, B.M.R., Kaneshiro, M., Russell, M.M. et al. J Gastrointest Surg (2014) 18: 1795. doi:10.1007/s11605-014-2597-y

Abstract

Background

Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.

Study Design

AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.

Results

There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).

Conclusion

Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.

Keywords

Postoperative IleusBiosensorHealth technology

Copyright information

© The Society for Surgery of the Alimentary Tract 2014