Original Article

Journal of Gastrointestinal Surgery

, Volume 18, Issue 10, pp 1795-1803

Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus

  • Brennan M. R. SpiegelAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLADepartment of Medicine, Cedars-Sinai Medical CenterDepartment of Health Policy and Management, UCLA Fielding School of Public HealthUCLA/VA Center for Outcomes Research and Education (CORE)Division of Gastroenterology, West Los Angeles VA Medical Center Email author 
  • , Marc KaneshiroAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA
  • , Marcia M. RussellAffiliated withDepartment of Surgery, VA Greater Los Angeles Healthcare SystemDepartment of Surgery, David Geffen School of Medicine at UCLA
  • , Anne LinAffiliated withDepartment of Surgery, David Geffen School of Medicine at UCLA
  • , Anish PatelAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemDepartment of Medicine, Cedars-Sinai Medical Center
  • , Vartan C. TashjianAffiliated withDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA
  • , Vincent ZegarskiAffiliated withUCLA Wireless Health Institute, Henry Samueli School of Engineering and Applied Science
  • , Digvijay SinghAffiliated withUCLA Wireless Health Institute, Henry Samueli School of Engineering and Applied Science
  • , Samuel E. CohenAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemDepartment of Medicine, Cedars-Sinai Medical Center
    • , Mark W. ReidAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemUCLA/VA Center for Outcomes Research and Education (CORE)
    • , Cynthia B. WhitmanAffiliated withUCLA/VA Center for Outcomes Research and Education (CORE)
    • , Jennifer TalleyAffiliated withDepartment of Medicine, VA Greater Los Angeles Healthcare SystemUCLA/VA Center for Outcomes Research and Education (CORE)
    • , Bibiana M. MartinezAffiliated withUCLA/VA Center for Outcomes Research and Education (CORE)
    • , William KaiserAffiliated withDepartment of Surgery, VA Greater Los Angeles Healthcare SystemUCLA Wireless Health Institute, Henry Samueli School of Engineering and Applied ScienceElectrical Engineering Department, University of California, Los Angles Email author 

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Abstract

Background

Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.

Study Design

AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.

Results

There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).

Conclusion

Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.

Keywords

Postoperative Ileus Biosensor Health technology