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Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Purpose

There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection.

Patients and Methods

Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed.

Results

Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24.1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS.

Conclusions

The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5–10-cm HCC.

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Authors and Affiliations

  1. Department of Surgery, Yonsei University College of Medicine, 134, Shinchon-dong, Seodaemun-gu, Seoul, 120-752, South Korea

    Sung Hoon Kim, Jae Gil Lee, Jin Sub Choi & Kyung Sik Kim

  2. Department of Surgery, Korea University College of Medicine, Seoul, South Korea

    Sae Byeol Choi

  3. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Seung Up Kim & Do Young Kim

  4. Department of Radiology, Yonsei University College of Medicine, Seoul, South Korea

    Mi-Suk Park

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  1. Sung Hoon Kim
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  2. Sae Byeol Choi
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  4. Seung Up Kim
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  7. Jin Sub Choi
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Correspondence to Kyung Sik Kim.

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Grant Support

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084120).

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Kim, S.H., Choi, S.B., Lee, J.G. et al. Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy. J Gastrointest Surg 15, 598–607 (2011). https://doi.org/10.1007/s11605-011-1452-7

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  • DOI: https://doi.org/10.1007/s11605-011-1452-7

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