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Pathologie der Lupus-Nephritis

Pathology of lupus nephritis

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Zusammenfassung

Der systemische Lupus erythematosus (SLE) ist eine Autoimmunerkrankung, die durch die Synthese antinukleärer Antikörper gekennzeichnet ist. Nucleosomen, bestehend aus Histonen und DNA, sind die primäre antigene Struktur, die zur Bildung komplementaktivierender Antigen-Antikörper-Komplexe an Basalmembranen führt. Die lichtmikroskopische, immunhistologische und ultrastrukturelle Diagnostik von Haut- und Nierenbiopsien kann zur Diagnosesicherung, Abschätzung der Prognose und zu Therapieentscheidungen wesentlich beitragen, insbesondere wenn semiquantitative Aktivitäts- und Chronizitätsscores ermittelt werden.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by synthesis of antinuclear antibodies. Nucleosomes, composed of histones and DNA, are the primary antigenic structure, which leads to complement-activating antigen-antibody complexes deposited at the glomerular basement membrane. The diagnostic work-up of skin and kidney biopsies—by light microscopy, immunohistology and electron microscopy—contributes significantly to the diagnosis, assessment of prognosis and therapeutic decisions. Semiquantitative scores of activity and chronicity improve the value of a histopathologic renal biopsy report.

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  1. Abteilung Zelluläre & Molekulare Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland

    E.F. Gröne &  H.J. Gröne

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  1. E.F. Gröne
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  2. H.J. Gröne
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Correspondence to H.J. Gröne.

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Gröne, E., Gröne, H. Pathologie der Lupus-Nephritis. Nephrologe 3, 195–202 (2008). https://doi.org/10.1007/s11560-008-0176-5

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  • DOI: https://doi.org/10.1007/s11560-008-0176-5

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