Abstract
In this study, objective differences between the Cold (Han) and Hot (Re) nature of traditional Chinese medicines, e.g. Strobal and Rhubarb, are determined by using a cold/hot plate differentiation technology. A novel, self-designed cold/hot plate differentiating instrument, with methodological study, was used to investigate the intervention of Strobal and Rhubarb on the temperature tropism of mice. Compared with the ICR and BALB/c mice, it was found that KM mice on the cold/hot plate were more sensitive to the change of temperature, within the tolerant temperature range of 15–40 °C The temperature tropism behavior of mice is influenced by treatment with Rhubarb and Strobal, as is the activity of ATPase in liver tissue. These trends are consistent with the definition of the Cold/Hot nature of Chinese medicines based on traditional Chinese medicinal theory. This study showed that the differences of the Cold/Hot nature of traditional Chinese medicines. might be objectively represented by the temperature tropism of animal by means of cold/hot differentiating assay.
Similar content being viewed by others
References
Gao X M. Traditional Chinese Medicine. Beijing: China Press of Traditional Chinese Medicine, 2002. 21
Yu H M, Xiao X H, Liu T S. Biothermodynamic study on four properties of Chinese traditional medicine I. comparison of properties of Radix Ginseng and Radix Ginseng by microcalorimetry. China J Chin Mater Med, 2002, 27: 76–79
Xiao X H, Jin C, Zhao Y L, et al. Biothermodynamics expression for the phamacotendency of traditional Chinese drugs and its application. J US-China Med Sci, 2006, 3: 1–6 1:CAS:528:DC%2BD28XpslWhsrk%3D
Aguiar P, Mendonça L, Galhardo V. Open control: A free open source software for video tracking and automated control of behavioral mazes. J Neurosci Methods, 2007, 166: 66–72 10.1016/j.jneumeth.2007.06.020, 17681380
Zhou C P, Wang J B, Zhang X R, et al. Investigation of the differences between the “COLD” and “HOT” nature of Coptis chinensis Franch and its processed material based on animal’s temperature tropism. Sci China Ser C-Life Sci, 2009, 52: 1073–1080 10.1007/s11427-009-0146-9
Reynolds W W. Casterlin M E. Behavioral thermoregulation and the “final preferendum” paradiuma. Am Zool, 1979, 19: 211–224
Fry F E J. Effects of the environment on animal activity. Univ Toronto Stud Biol Ser. 1947, 68: 1–62
Wang L Zh, Li X C, Sun T. Preferred temperature, avoidance temperature and lethal temperature of tadpoles of the common Giant Toad (Bufogargarizans) and the Chinese Forest Frog (Rana chensinensis), Chin J Zool, 2005, 40: 23–27
Xiao P G, Xiao X H. The 21st century and modernization of Chinese medicine. China J Chin Mater Med, 2000, 25: 3–6
Li Y Q. Question probe on essential property of four Qi. Shizhen J Tradit Chin Med Res, 1993, 4: 6–8
Chen R Q, Yu Z Y, Zhang X Y. Rhizoma anemarrhenae sapogenin is the inhibitor of Na+-K+-ATPase. Acta Biochim et Biophys Sinica. 1982, 14: 159–164 1:CAS:528:DyaL38XlvFarsbw%3D
Ding A R, Li S L, Wang Z Q. Impact of Rhubarb and Fructus gardeniae on the activity of Na+-K+-ATPase in red cell membrane of mouse. China J Chin Mater Med, 1990, 15: 52–53
Chen R Q, Zhang X Y, Gu T J. Impact of Epimedium and prepared Commonot on the activity of Na+ pump in red cell membrane of rat. J Shanghai Med (Univ), 1986, 13: 389–392
Li Y Q. The Century Review of Pharmacology of Chinese Materia Medica. Chin Tradit Patent Med, 2000, 22: 61–72 1:CAS:528:DC%2BD3cXns12gsLk%3D
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the National Basic Research and Development Program of China (Grant No. 2007CB512607)
Rights and permissions
About this article
Cite this article
Zhao, H., Zhao, Y., Wang, J. et al. Expression of the difference between the Cold (Han) and Hot (Re) natures of traditional Chinese medicines (Strobal and Rhubarb) based on the cold/hot plate differentiating assay. SCI CHINA SER C 52, 1192–1197 (2009). https://doi.org/10.1007/s11427-008-0154-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-008-0154-1