, Volume 27, Issue 2, pp 225-239
Date: 05 Mar 2012

Computational Challenges in Characterization of Bacteria and Bacteria-Host Interactions Based on Genomic Data

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Abstract

With the rapid development of next-generation sequencing technologies, bacterial identification becomes a very important and essential step in processing genomic data, especially for metagenomic data. Many computational methods have been developed and some of them are widely used to address the problems in bacterial identification. In this article we review the algorithms of these methods, discuss their drawbacks, and propose future computational methods that use genomic data to characterize bacteria. In addition, we tackle two specific computational problems in bacterial identification, namely, the detection of host-specific bacteria and the detection of disease-associated bacteria, by offering potential solutions as a starting point for those who are interested in the area.

This work was partially supported by the National Institute of Health of USA under Grant No. R21/R33 GM078601, USDA NIFA’s Evans-Allen Grant (Project NO: MOX-Zheng) under Grant No. 0223248, and International Exchange and Cooperation Office of Nanjing Medical University of China.