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Conceptual analysis and special-interest science: toxicology and the case of Edward Calabrese

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Abstract

One way to do socially relevant investigations of science is through conceptual analysis of scientific terms used in special-interest science (SIS). SIS is science having welfare-related consequences and funded by special interests, e.g., tobacco companies, in order to establish predetermined conclusions. For instance, because the chemical industry seeks deregulation of toxic emissions and avoiding costly cleanups, it funds SIS that supports the concept of “hormesis” (according to which low doses of toxins/carcinogens have beneficial effects). Analyzing the hormesis concept of its main defender, chemical-industry-funded Edward Calabrese, the paper shows Calabrese and others fail to distinguish three different hormesis concepts, H, HG, and HD. H requires toxin-induced, short-term beneficial effects for only one biological endpoint, while HG requires toxin-induced, net-beneficial effects for all endpoints/responses/subjects/ages/conditions. HD requires using the risk-assessment/regulatory default rule that all low-dose toxic exposures are net-beneficial, thus allowable. Clarifying these concepts, the paper argues for five main claims. (1) Claims positing H are trivially true but irrelevant to regulations. (2) Claims positing HG are relevant to regulation but scientifically false. (3) Claims positing HD are relevant to regulation but ethically/scientifically questionable. (4) Although no hormesis concept (H, HG, or HD) has both scientific validity and regulatory relevance, Calabrese and others obscure this fact through repeated equivocation, begging the question, and data-trimming. Consequently (5) their errors provide some undeserved rhetorical plausibility for deregulating low-dose toxins.

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References

  • Allen v. Pennsylvania Engineering Corp. (APEC) (1996). 102 V.3d 194, 195 (5thCir.).

  • American Association for the Advancement of Science (AAAS): (1980) Principles of scientific freedom and responsibility. AAAS, Washington, DC

    Google Scholar 

  • American Journal of Epidemiology (AJE). (1984). Retrieved November 26, 2008, from http://aje.oxfordjournals.org/cgi/issue_pdf/backmatter_pdf/119/6.pdf.

  • Aristotle (1985) Nicomachean ethics, trans. Terence Irwin. Hackett, Indianapolis

    Google Scholar 

  • Axelrod D., Burns K., Davis D., Von Larebeke N. (2004) Hormesis—An inappropriate extrapolation from the specific to the universal. International Journal of Occupational and Environmental Health 10: 335–339

    Google Scholar 

  • Beauchamp T., Childress J. (1989) Principles of biomedical ethics. Oxford University Press, New York

    Google Scholar 

  • Calabrese, E. J. (1993). Did occupational exposure to ETO Cause Mr. Walter Allen’s brain tumor? Unpublished Report, April 13.

  • Calabrese, E. J. (2002a). Curriculum vitae, University of Massachusetts. Retrieved January 3, 2007 from http://people.umass.edu/nrephc/EJCCVApril02.pdf.

  • Calabrese, E. J. (2002b). Curriculum vitae, University of Massachusetts. Retrieved November 24, 2008 from http://people.umass.edu/nrephc/EJCCVApril02.pdf.

  • Calabrese E. J. (2005) Historical blunders: How toxicology got the dose-response relationship half right. Cellular and Molecular Biology 51: 643–654

    Google Scholar 

  • Calabrese, E. J. (2006a). Resume, University of Massachusetts. Retrieved January 30, 2007, from http://www.umassmarine.net/faculty/showprofs.cfm?prof_ID=30.

  • Calabrese, E. J. (2006b). Resume, University of Massachusetts. Retrieved November 24, 2008 from http://www.umassmarine.net/faculty/showprofs.cfm?prof_ID=30.

  • Calabrese, E. J. (2007). Curriculum vitae, University of Massachusetts. Retrieved January 3, 2007 from http://people.umass.edu/nrephc/EJCCVApril02.pdf and http://www.umassmarine.net/faculty/showprofs.cfm?prof_ID=30.

  • Calabrese, E. J. & Baldwin, L. A. (1998). Chemical hormesis: scientific foundations, unpublished final report of the Texas Institute for Advancement of Chemical Technology. Retrieved November 22, 2006 from http://cheweb.tamu.edu/tiact/index_files/Page536.htm.

  • Calabrese E. J., Baldwin L. A. (1999) Reevaluation of the fundamental dose: Response relationship. BioScience 49: 725–732

    Article  Google Scholar 

  • Calabrese E. J., Baldwin E. J. (2001) Hormesis: U-shaped dose responses and their centrality in toxicology. Trends in Pharmacological Sciences 22: 285–291

    Article  Google Scholar 

  • Calabrese E. J., Baldwin L. A. (2002) Defining hormesis. Human and Experimental Toxicology 21: 91–97

    Article  Google Scholar 

  • Calabrese E. J., Baldwin L. A. (2003a) Hormesis: The dose–response revolution. Annual Review of Pharmacology and Toxicology 43: 175–197

    Article  Google Scholar 

  • Calabrese E. J., Baldwin L. A. (2003b) Toxicology rethinks its central belief. Nature 421: 691–692

    Article  Google Scholar 

  • Calabrese E. J., Baldwin L. A., Holland C. (1999) Hormesis: A highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Analysis 19: 261–281

    Google Scholar 

  • Calabrese E. J., Cook R. (2005) Hormesis: How it could affect the risk assessment process. BELLE 12: 22–27

    Google Scholar 

  • Cook R., Calabrese E. J. (2006a) Hormesis is biology, not religion. Environmental Health Perspectives 114(12): A668

    Article  Google Scholar 

  • Cook, R. & Calabrese, E. J. (2006b). The importance of hormesis to public health. Environmental Health Perspectives, 114, 1631–1635. Retrieved November 22, 2006, from http://www.ehponline.org/members/2006/8606/8606.pdf.

  • Cranor C. (2006) Toxic torts. Cambridge University Press, New York

    Book  Google Scholar 

  • Cranor, C. (2008). Personal Communication Regarding Allen v. Pennsylvania Engineering, Document C, email to Kristin Shrader-Frechette. Received November 24, 2008, at kshrader@nd.edu.

  • David, E. R. and the Panel on Scientific Responsibility and the Conduct of Research (1992). Responsible science. Washington, DC: National Academy Press.

  • Ehrenberg L., Hiesche K. D., Osterman-Golkar S., Wennberg I. (1974) Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide. Mutation Research 24: 83–103

    Article  Google Scholar 

  • Elliott, K. (2007). Email to Kristin Shrader-Frechette. Received January 28, 2007, at kshrader@nd.edu

  • Elliott, K. (2008a). Email to Kristin Shrader-Frechette. Received October 3, 2008a, at kshrader@nd.edu

  • Elliott, K. (2008b). Email to Kristin Shrader-Frechette. Received November 13, 2008b, at kshrader@nd.edu

  • Faden R., Beauchamp T. (1986) A history and theory of informed consent. Oxford University Press, New York

    Google Scholar 

  • Flanagin A., Fontanarosa P., DeAngelis C. (2006) Update on JAMA’s conflict of interest policy. Journal of the American Medical Association 296(2): 220–221

    Article  Google Scholar 

  • Greenland S. (1990) Randomization, statistics, and causal inferences. Epidemiology 1: 421–429

    Article  Google Scholar 

  • Hume D. (1975) A treatise of human nature. Clarendon Press, Oxford

    Google Scholar 

  • International Agency for Research on Cancer (IARC). (1994). Ethylene Oxide CAS No.: 75-21-8. Monographs 60, 73; Retrieved November 24, 2008, from http://www.inchem.org/documents/iarc/vol60/m60-02.html.

  • Jackson C. I. (1986) Honor in science. Sigma Xi the Scientific Research Society, New Haven

    Google Scholar 

  • Jennings, B., Kahn, J., Mastroianni, A., Parker, L. (eds) (2003) Ethics and public health. Association of Schools of Public Health, Washington, DC

    Google Scholar 

  • Kociba R. J., Keyes D. G., Beyer J. E. (1978) Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicology and Applied Pharmacology 46: 279–303

    Article  Google Scholar 

  • Krimsky S. (2003) Science in the private interest. Rowman and Littlefield, Savage, MD

    Google Scholar 

  • Lang L. (1995) Strange brew. Environmental Health Perspectives 103: 142–145

    Article  Google Scholar 

  • Lockwood A. H. (2004) Human testing of pesticides. American Journal of Public Health 94: 1908–1915

    Article  Google Scholar 

  • Mayr E. (1988) Toward a new philosophy of Biology. Belknap Press, Cambridge, MA

    Google Scholar 

  • Mead, M. N. (2006). Sour finding on popular sweetener. Environmental Health Perspectives 114. Retrieved November 22, 2006, from http://www.ehponline.org/docs/2006/114-3/ss.html.

  • NationalResearch Council (NRC): (2004) Intentional human dosing studies for EPA regulatory purposes. National Academy Press, Washington, DC

    Google Scholar 

  • Oleskey C., Fleishman A., Goldman L. R. (2004) Pesticide testing in humans. Environmental Health Perspectives 112: 114–119

    Article  Google Scholar 

  • Reir S. E., Martin D. C., Bowman R. E., Domowski W. P., Becker J. L. (1993) Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundamentals of Applied Toxicology 421: 433–441

    Article  Google Scholar 

  • Rothman K. J. (1990) Statistics in non-randomized studies. Epidemiology 1: 417–418

    Article  Google Scholar 

  • Rothman K. J. (2002) Epidemiology. Oxford University Press, New York

    Google Scholar 

  • Rourke, L. J. (2008a). Email to Kristin Shrader-Frechette. Received November 13, 2008a, at kshrader@nd.edu

  • Rourke, L. J. (2008b). Email to Kristin Shrader-Frechette. Received November 27, 2008b, at kshrader@nd.edu

  • Scientific Advisory Board and FIFRA Scientific Advisory Panel (SAB). (2000). Comments on the use of data from testing of human subjects, EPA-SAB-EC-00-017. Washington, DC: EPA.

  • Shrader-Frechette K. (1991) Nuclear energy and ethics edited volume. World Council of Churches, Geneva, p 233

    Google Scholar 

  • Shrader-Frechette K. (1993a) Risk and rationality. University of California Press, Berkeley

    Google Scholar 

  • Shrader-Frechette K. (1993b) Burying uncertainty. University of California Press, Berkeley

    Google Scholar 

  • Shrader-Frechette K. (1994) Ethics of scientific research. Rowman and Littlefield, New York

    Google Scholar 

  • Shrader-Frechette K. (2001) Using a thought experiment to clarify a radiobiological controversy. Synthese 128: 319–342

    Article  Google Scholar 

  • Shrader-Frechette K. (2002) Environmental justice. Oxford University Press, New York

    Book  Google Scholar 

  • Shrader-Frechette K. (2007) Taking action, saving lives: our duties to protect environmental and public health. Oxford University Press, New York

    Google Scholar 

  • Shrader-Frechette, K. (2008a). Email to Kevin Elliott. Sent on November 11.

  • Shrader-Frechette K. (2008b) Evidentiary standards and animal data. Environmental Justice 1(3): 1–6

    Article  Google Scholar 

  • Shrader-Frechette K. (2008c) Ideological toxicology: Invalid, logic, science, ethics about low-dose pollution. Biological Effects of Low-Level Exposures 14(4): 39–47

    Google Scholar 

  • Shrader-Frechette K. (2008d) Ideological toxicology: Invalid, logic, science, ethics about low-dose pollution. Human and Experimental Toxicology 27: 647–657

    Article  Google Scholar 

  • Shrader-Frechette K. (2008e) Statistical significance in biology: Neither necessary nor sufficient for hypothesis-acceptance. Biological Theory 3(1): 12–16

    Article  Google Scholar 

  • Shrader-Frechette, K. (2009a). Environmental justice. A syllabus for a graduate/undergraduate course, offered for philosophy or for biological-sciences credit, in which students do pro-bono scientific work assessment draft, science-related government assessments affecting poor and minority communities. Accessed 9-6-09 at www.nd.edu/~kshrader/courses.

  • Shrader-Frechette, K. (2009b). Center for Environmental Justice and Children’s Health. An overview of the 20–30 annual, pro-bono, science-related projects done by faculty and students who use methodological analysis of scientific assessments to promote better science and better science-related public policy. Accessed 9-6-09 at www.nd.edu/~kshrader/cejch.html.

  • Sulovska K., Lindgren D., Eriksson G., Ehrenberg L. (1969) The mutagenic effect of low concentrations of ethylene oxide in air. Hereditas 6: 264–266

    Google Scholar 

  • Thayer K. A., Melnick R., Burns K., Davis D., Huff J. (2005) Fundamental flaws of hormesis for public health decisions. Environmental Health Perspectives 113: 1272–1275

    Article  Google Scholar 

  • University of Massachusetts. (1997). Policy on Conflicts of Interest, doc. T96-039 (Amherst and Boston: University of Massachusetts). Retrieved October 1, 2009 from http://www.umass.edu/research/ora/conflict.html.

  • US National Research Council (US NRC): (1993) Measuring lead exposure in infants, children. National Academy Press, Washington, DC

    Google Scholar 

  • Wing S. (2003) Objectivity and ethics and environmental health science. Environmental Health Perspectives 111(14): 1809–1818

    Article  Google Scholar 

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  1. Department of Philosophy and Department of Biological Sciences, Center for Environmental Justice and Children’s Health, University of Notre Dame, 100 Malloy Hall, Notre Dame, IN, 46556, USA

    Kristin Shrader-Frechette

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Shrader-Frechette, K. Conceptual analysis and special-interest science: toxicology and the case of Edward Calabrese. Synthese 177, 449–469 (2010). https://doi.org/10.1007/s11229-010-9792-5

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