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A simple, rapid, and efficient oxidation of oximes to ketones and aldehydes with manganese dioxide catalyzed by kieselguhr under solvent-free conditions

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Abstract

A simple, rapid, and efficient oxidation of oximes to the corresponding ketones and aldehydes with manganese dioxide catalyzed by kieselguhr under solvent-free conditions at room temperature in the yields between 82 and 98 is described. It seems that kieselguhr in the present procedure can highly expedite the reaction rate. By comparing to other methods described previously, the main advantages of this oxidation are that the oxidations are more efficient, the reaction conditions are milder, the reaction times are shorter, and the work-up is easier. Furthermore, the amount of manganese dioxide used in this oxidation is largely decreased.

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Authors and Affiliations

  1. College of Life Sciences, China Jiliang University, Hangzhou, 310018, Zhejiang, China

    Wenjin Zheng, Yi-Feng Zhou & Ji-Dong Lou

  2. China Pharmaceutical University, Nanjing, 210009, Jiangsu, China

    Chen Huang

  3. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB)/Department of Biology and Environment, Universidade de Trás-os-Montes e Alto Douro (UTAD), Apartado 1013, 5001-801, Vila Real, Portugal

    Changhe Zhang

  4. Sirnaomics, Inc, 401 Professional Drive, Gaithersburg, MD, 20879, USA

    Ji-Dong Lou

Authors
  1. Wenjin Zheng
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  2. Chen Huang
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  3. Changhe Zhang
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  4. Yi-Feng Zhou
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Corresponding authors

Correspondence to Yi-Feng Zhou or Ji-Dong Lou.

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Zheng, W., Huang, C., Zhang, C. et al. A simple, rapid, and efficient oxidation of oximes to ketones and aldehydes with manganese dioxide catalyzed by kieselguhr under solvent-free conditions. Res Chem Intermed 39, 499–504 (2013). https://doi.org/10.1007/s11164-012-0573-2

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