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Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments

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Abstract

The phenomenon of protein synthesis has been modeled in terms of totally asymmetric simple exclusion processes (TASEP) since 1968. In this article, we provide a tutorial of the biological and mathematical aspects of this approach. We also summarize several new results, concerned with limited resources in the cell and simple estimates for the current (protein production rate) of a TASEP with inhomogeneous hopping rates, reflecting the characteristics of real genes.

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  1. Physics Department, Virginia Tech, Blacksburg, VA, 24061, USA

    R. K. P. Zia, J. J. Dong & B. Schmittmann

  2. Physics Department, Hamline University, St. Paul, MN, 55104, USA

    J. J. Dong

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  1. R. K. P. Zia
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  3. B. Schmittmann
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Zia, R.K.P., Dong, J.J. & Schmittmann, B. Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments. J Stat Phys 144, 405–428 (2011). https://doi.org/10.1007/s10955-011-0183-1

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