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Improvement of pharmaceutical potential of all-trans retinoic acid with hydroxypropyl-β-cyclodextrin

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Abstract

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) includes all-trans retinoic acid (RA), covering the double-bond area of RA with substituted hydroxypropyl groups on CyD ring, as proved by the nuclear Overhauser effect (NOE) between methylene protons on the hydroxypropyl groups and the proton on RA. The formation of an inclusion complex results in hydrophilicity and stability. The effect of RA/HP-β-CyD and that of RA without HP-β-CyD on wrinkle scores and skin elasticity during skin treatment were identical, and the cutaneous stimulus was reduced comparing with RA. The results indicated that the RA/HP-β-CyD complex should help to realize new approaches in skin rejuvenation therapy.

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Authors and Affiliations

  1. Department of Life Science and Sustainable Chemistry, Faculty of Engineering, The Center for Nanoscience and Technology, Tokyo Polytechnic University, 1583 Iiyama, Atsugi Kanagawa, 243-0297, Japan

    Keiko Takahashi, Sayo Morimoto, Hiroto Nakamura & Toshiaki Narusawa

  2. Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan

    Taizo Seki & Keigo Aoi

  3. Department of Cosmetic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan

    Masahiko Ooe & Akiyoshi Takada

  4. Development Laboratory, Tokiwa Pharmaceutical Co., Ltd, 6-13-1 Minatojima Nakamachi, Chuou-ku, Kobe Hyougo, 650-8521, Japan

    Taizo Seki & Masahiko Ooe

Authors
  1. Keiko Takahashi
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  2. Sayo Morimoto
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  3. Hiroto Nakamura
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  4. Toshiaki Narusawa
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  5. Taizo Seki
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  6. Masahiko Ooe
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  7. Keigo Aoi
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  8. Akiyoshi Takada
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Correspondence to Keiko Takahashi.

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15th International Cyclodextrin Symposium.

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Takahashi, K., Morimoto, S., Nakamura, H. et al. Improvement of pharmaceutical potential of all-trans retinoic acid with hydroxypropyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem 70, 389–396 (2011). https://doi.org/10.1007/s10847-010-9857-6

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  • DOI: https://doi.org/10.1007/s10847-010-9857-6

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