ISCEV Standards

Documenta Ophthalmologica

, Volume 120, Issue 1, pp 111-119

ISCEV standard for clinical visual evoked potentials (2009 update)

  • J. Vernon OdomAffiliated withWest Virginia University Eye Institute Email author 
  • , Michael BachAffiliated withUniversitäts-Augenklinik, University of Freiburg
  • , Mitchell BrigellAffiliated withNovartis Institutes for BioMedical Research, Inc.
  • , Graham E. HolderAffiliated withMoorfields Eye Hospital
  • , Daphne L. McCullochAffiliated withVision Sciences, Glasgow Caledonian University
  • , Alma Patrizia TormeneAffiliated withDepartment of Neurosciences, Ophthalmic Clinic, Padova University
  • , VaeganAffiliated withVisiontest Australia


Visual evoked potentials (VEPs) can provide important diagnostic information regarding the functional integrity of the visual system. This document updates the ISCEV standard for clinical VEP testing and supersedes the 2004 standard. The major change in this revision is that test parameters have been made more precise to achieve better consistency of results within and between test centers. The ISCEV standard VEP protocols are defined for a single recording channel with a midline occipital active electrode. These protocols are intended for assessment of prechiasmal function; additional electrode sites are recommended for evaluation of chiasmal and postchiasmal function. ISCEV has selected a subset of stimulus and recording conditions that provide core clinical information and can be performed by most clinical electrophysiology laboratories throughout the world. These are: 1. Pattern-reversal VEPs elicited by checkerboard stimuli with large 1° (i.e., 60 min of arc; min) and small 0.25° (15 min) checks. 2. Pattern onset/offset VEPs elicited by checkerboard stimuli with large 1° (60 min) and small 0.25° (15 min) checks. 3. Flash VEP elicited by a brief luminance increment, a flash, which subtends a visual field of at least 20°.


Visual evoked potential Standard Pattern reversal Flash Pattern onset/offset Visually evoked potential Visually evoked cortical potential