Digestive Diseases and Sciences

, Volume 59, Issue 10, pp 2529–2535

Mucosal Healing Predicts the Long-Term Prognosis of Intestinal Behçet’s Disease

  • Sun Mie Yim
  • Duk Hwan Kim
  • Hyun Jung Lee
  • Hui Won Jang
  • Soo Jung Park
  • Sung Pil Hong
  • Tae Il Kim
  • Won Ho Kim
  • Jae Hee Cheon
Original Article

DOI: 10.1007/s10620-014-3198-z

Cite this article as:
Yim, S.M., Kim, D.H., Lee, H.J. et al. Dig Dis Sci (2014) 59: 2529. doi:10.1007/s10620-014-3198-z

Abstract

Background

Mucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Behçet’s disease (BD).

Aim

We investigated whether MH could predict the prognosis of intestinal BD.

Methods

We retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan–Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD.

Results

The number of patients with active ulcers at the time of clinical remission was 57 (71.3 %), while 23 patients (28.7 %) were experiencing MH. In the active ulcer group, 39 patients (68.4 %) experienced recurrence during the follow-up period, whereas 7 patients (30.4 %) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse.

Conclusion

Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.

Keywords

Intestinal Behçet’s diseaseMucosal healingInflammatory bowel disease

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Sun Mie Yim
    • 1
  • Duk Hwan Kim
    • 1
  • Hyun Jung Lee
    • 1
  • Hui Won Jang
    • 1
  • Soo Jung Park
    • 1
  • Sung Pil Hong
    • 1
  • Tae Il Kim
    • 1
    • 2
  • Won Ho Kim
    • 1
    • 2
  • Jae Hee Cheon
    • 1
    • 2
  1. 1.Department of Internal Medicine and Institute of GastroenterologyYonsei University College of MedicineSeoulKorea
  2. 2.Brain Korea 21 Project for Medical ScienceYonsei UniversitySeoulKorea