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Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B

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Abstract

Background It is difficult to differentiate early compensated cirrhosis from chronic hepatitis solely by clinical features. The aim of this study was to assess the usefulness of liver stiffness measurement (LSM) for detection of early compensated liver cirrhosis in chronic hepatitis B (CHB). Methods Ninety-one consecutive CHB patients who underwent liver biopsy (LB) and LSM were recruited. All patients did not fulfill the clinical criteria for cirrhosis. The cutoff of LSM for cirrhosis was 10.3 kPa. Results All patients were divided into either group A (cirrhosis) or group B (CHB) according to LB result. The median LSM values of groups A and B were 11.8 and 7.6 kPa, respectively (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of LSM in predicting cirrhosis were 0.59, 0.78, 0.68, and 0.72, respectively. The area under the receiver operating characteristics curve (AUROC) of LSM was 0.803, whereas the AUROCs of aspartate to alanine aminotransferase ratio (AAR) and aspartate aminotransferase to platelet ratio index (APRI) were 0.488 and 0.723, respectively. Conclusions LSM showed an acceptable diagnostic accuracy for detecting early compensated cirrhosis in CHB.

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Acknowledgments

This study was supported by the grant of the Good Health R & D Project from the Ministry of Health and Welfare, Republic of Korea (A050021), and in part by a grant from Brain Korea 21 Project for Medical Science.

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Authors and Affiliations

  1. Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, South Korea

    Do Young Kim, Seung Up Kim, Sang Hoon Ahn, Jun Yong Park, Jung Min Lee, Ki Tae Yoon, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon & Kwang-Hyub Han

  2. Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea

    Young Nyun Park

  3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea

    Do Young Kim, Sang Hoon Ahn, Jun Yong Park, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon & Kwang-Hyub Han

  4. Liver Cirrhosis Clinical Research Center, Seoul, South Korea

    Do Young Kim, Seung Up Kim, Sang Hoon Ahn, Jun Yong Park, Jung Min Lee, Young Nyun Park, Ki Tae Yoon, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon & Kwang-Hyub Han

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  1. Do Young Kim
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Correspondence to Kwang-Hyub Han.

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Do Young Kim and Seung Up Kim have contributed equally to this work.

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Kim, D.Y., Kim, S.U., Ahn, S.H. et al. Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B. Dig Dis Sci 54, 1758–1763 (2009). https://doi.org/10.1007/s10620-008-0541-2

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  • DOI: https://doi.org/10.1007/s10620-008-0541-2

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