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Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities

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Chemistry of Natural Compounds Aims and scope

A new alkaloid, 6-hydroxy-β-carboline-1-carboxylic acid (1), together with six known alkaloids, including β-carboline-1-carboxylic acid (2), β-carboline-1-propanoic acid (3), 1-methoxycarbonyl-β-carboline (4), 3-methylcanthin-5,6-dione (5), 5-hydroxy-4-methoxycanthin-6-one (6), and 4,5-dimethoxycanthin-6-one (7), were isolated from the stem of Picrasma quassioides. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–7 were screened for their cytotoxic activities against five cancer cell lines such as CT26.WT, K-562, SGC-7901, Hep G2, and A-549. Among the seven alkaloids tested, only compound 2 exhibited moderate inhibitory activities against K-562 and SGC-7901 cell lines.

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Acknowledgment

The authors are grateful for financial support from the State Natural Science Funds Commission of the People’s Republic of China (Project No. u0732004), the Science and Technology Planning Project of Guangdong Province (No. 2009A030100014), and the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2011).

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Authors and Affiliations

  1. New Drug Research & Development Center, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China

    Zheng-Quan Lai, Wei-Hai Liu, Hui-Jun Liao, Yu-Yang Yi, Zhen Qin, Xiao-Ping Lai & Zi-Ren Su

  2. School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, P. R. China

    Zheng-Quan Lai, Siu-Po Ip, Hui-Jun Liao & Zhi-Xiu Lin

  3. Dongguan Mathematical Engineering and Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, P. R. China

    Xiao-Ping Lai

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  1. Zheng-Quan Lai
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Correspondence to Zi-Ren Su or Zhi-Xiu Lin.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2014, pp. 764–767.

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Lai, ZQ., Liu, WH., Ip, SP. et al. Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities. Chem Nat Compd 50, 884–888 (2014). https://doi.org/10.1007/s10600-014-1106-6

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  • DOI: https://doi.org/10.1007/s10600-014-1106-6

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