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Effect of the solvent nature on the course of quaternization of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine

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Chemistry of Heterocyclic Compounds Aims and scope

The effect of the solvent nature and temperature on the quaternization of 3,5-diethoxycarbonyl-2,6-di- methyl-4-(3-pyridyl)-1,4-dihydropyridine by lipophilic alkyl bromides has been investigated. By comparison of the solvent effect (acetone, acetonitrile, and 2-butanone) on the alkylation of the pyridine fragment of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine it was established that conducting the reaction in acetonitrile at 81 °C is the most optimal.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., Riga, LV-1006, Latvia

    K. Pajuste, M. Gosteva, D. Kaldre, M. Plotniece, B. Cekavicus, A. Sobolev, G. Tirzitis, G. Duburs & A. Plotniece

  2. Faculty of Chemistry, University of Latvia, 48 Kr. Valdemara Str., Riga, LV-1013, Latvia

    A. Priksane

Authors
  1. K. Pajuste
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  2. M. Gosteva
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  3. D. Kaldre
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  4. M. Plotniece
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  6. A. Sobolev
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  8. G. Tirzitis
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  9. G. Duburs
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  10. A. Plotniece
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Correspondence to A. Plotniece.

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Dedicated to Academician Valery Nikolaevich Charushin on his jubilee.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 721–726, May, 2011.

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Pajuste, K., Gosteva, M., Kaldre, D. et al. Effect of the solvent nature on the course of quaternization of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine. Chem Heterocycl Comp 47, 597–601 (2011). https://doi.org/10.1007/s10593-011-0803-3

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  • DOI: https://doi.org/10.1007/s10593-011-0803-3

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