Cancer Causes & Control

, Volume 21, Issue 8, pp 1193–1201

Mumps and ovarian cancer: modern interpretation of an historic association

  • Daniel W. Cramer
  • Allison F. Vitonis
  • Simone P. Pinheiro
  • John R. McKolanis
  • Raina N. Fichorova
  • Kevin E. Brown
  • Todd F. Hatchette
  • Olivera J. Finn
Original paper

DOI: 10.1007/s10552-010-9546-1

Cite this article as:
Cramer, D.W., Vitonis, A.F., Pinheiro, S.P. et al. Cancer Causes Control (2010) 21: 1193. doi:10.1007/s10552-010-9546-1

Abstract

Background

Epidemiologic studies found childhood mumps might protect against ovarian cancer. To explain this association, we investigated whether mumps might engender immunity to ovarian cancer through antibodies against the cancer-associated antigen MUC1 abnormally expressed in the inflamed parotid gland.

Methods

Through various health agencies, we obtained sera from 161 cases with mumps parotitis. Sera were obtained from 194 healthy controls. We used an ELISA to measure anti-MUC1 antibodies and electro-chemiluminescence assays to measure MUC1 and CA 125. Log-transformed measurements were analyzed by t-tests, generalized linear models, and Pearson or Spearman correlations. We also conducted a meta-analysis of all published studies regarding mumps and ovarian cancer.

Results

Adjusting for assay batch, age, and sex, the level of anti-MUC1 antibodies was significantly higher in mumps cases compared to controls (p = 0.002). Free circulating levels of CA 125, but not MUC1, were also higher in cases (p = 0.02). From the meta-analysis, the pooled odds ratio estimate (and 95% CI) for the mumps and ovarian cancer association was 0.81 (0.68–0.96) (p = 0.01).

Conclusion

Mumps parotitis may lead to expression and immune recognition of a tumor-associated form of MUC1 and create effective immune surveillance of ovarian cancer cells that express this form of MUC1.

Keywords

Ovarian cancer Mumps parotitis MUC1 CA125 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Daniel W. Cramer
    • 1
  • Allison F. Vitonis
    • 1
  • Simone P. Pinheiro
    • 2
  • John R. McKolanis
    • 3
  • Raina N. Fichorova
    • 4
  • Kevin E. Brown
    • 5
  • Todd F. Hatchette
    • 6
    • 7
  • Olivera J. Finn
    • 3
  1. 1.Department of Obstetrics and Gynecology Epidemiology Center, Obstetrics and Gynecology Epidemiology CenterBrigham and Women’s Hospital (BWH), Harvard Medical SchoolBostonUSA
  2. 2.US Food and Drug AdministrationSilver SpringUSA
  3. 3.Department of ImmunologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  4. 4.Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive BiologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Centre for InfectionsHealth Protection AgencyLondonUK
  6. 6.Division of Microbiology, Department of Pathology and Laboratory MedicineQueen Elizabeth II Health Sciences CentreHalifaxCanada
  7. 7.Department of PathologyDalhousie UniversityHalifaxCanada

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