Maternal hair dye use and risk of neuroblastoma in offspring*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Objective: Studies have suggested an association between maternal hair dye use and elevated risk of childhood cancer, including neuroblastoma. We analyzed data from a large case–control study to investigate the relationship between maternal hair dye use around pregnancy and risk of neuroblastoma in offspring.
Methods: Cases were children with neuroblastoma diagnosed between 1992 and 1994 at hospitals in the United States and Canada participating in the Children’s Cancer Group or the Pediatric Oncology Group. Random-digit dialing was used to identify one matched control for each case. Information on hair dye use was gathered from telephone interviews of 538 case and 504 control mothers.
Results: Use of any hair dye in the month before and/or during pregnancy was associated with a moderately increased risk of neuroblastoma (adjusted odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.2–2.2). Temporary hair dye use (OR = 2.0, CI = 1.1–3.7) was more strongly associated with neuroblastoma than use of permanent hair dye (OR = 1.4, CI = 1.0–2.0).
Conclusion: Although the results of this study provide evidence of an association between maternal hair dye use and neuroblastoma, further research is necessary to evaluate effects by method of hair dye application, color, and chemical composition.
- Little, J (1999) Epidemiology of Childhood Cancer. International Agency for Research on Cancer, Lyon
- Goodman, MT, Gurney, JG, Smith, MA, Olshan, AF Sympathetic nervous system tumors. In: Ries, LAG, Smith, MA, Gurney, JG, Linet, M, Tamra, T, Young, JL, Bunin, GR eds. (1999) Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995. National Cancer Institute, Bethesda, MD, pp. 65-72
- Olshan, AF, Bunin, GR Epidemiology of Neuroblastoma. In: Brodeur, GM, Sawada, T, Tsuchida, Y, Voute, PA eds. (2000) Neuroblastoma. Elsevier, Amsterdam, pp. 33-39
- Holly, EA, Bracci, PM, Hong, MK, Mueller, BA, Preston-Martin, S (2002) West Coast study of childhood brain tumours and maternal use of hair-colouring products. Paediatr Perinat Epidemiol 16: pp. 226-235 CrossRef
- Kramer, S, Ward, E, Meadows, AT, Malone, KE (1987) Medical and drug risk factors associated with neuroblastoma: a case–control study. J Natl Cancer Inst 78: pp. 797-804
- Bunin, GR, Buckley, JD, Boesel, CP, Rorke, LB, Meadows, AT (1994) Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children’s Cancer Group. Cancer Epidemiol Biomarkers Prev 3: pp. 197-204
- Bunin, GR, Kramer, S, Marrero, O, Meadows, AT (1987) Gestational risk factors for Wilms’ tumor: results of a case–control study. Cancer Res 47: pp. 2972-2977
- International Agency for Research on Cancer (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines. Lyon, France: International Agency for Research on Cancer, pp. 43–53, 63–64, 93–94, 129–212.
- Nohynek, GJ, Fautz, R, Benech-Kieffer, F, Toutain, H (2004) Toxicity and human health risk of hair dyes. Food Chem Toxicol 42: pp. 517-543 CrossRef
- Tomatis, L Overview of perinatal and multigeneration carcinogenesis. In: Napalkov, NP, Rice, JM, Tomatis, L, Yamasaki, H eds. (1989) Perinatal and Multigeneration Carcinogenesis. International Agency for Research on Cancer, Lyon, France, pp. 1-15
- Olshan, AF, DeRoos, AJ, Teschke, K (1999) Neuroblastoma and parental occupation. Cancer Causes Control 10: pp. 539-549 CrossRef
- Olshan, AF, Smith, J, Cook, MN (1999) Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children’s Cancer Group and the Pediatric Oncology Group. Am J Epidemiol 150: pp. 930-938
- Carey, FA (1996) Organic Chemistry. University of Virginia, McGraw-Hill
- Lijinsky, W (1999) N-Nitroso compounds in the diet. Mutat Res 443: pp. 129-138
- Brodeur, GM, Maris, JM, Yamashiro, DJ, Hogarty, MD, White, PS (1997) Biology and genetics of human neuroblastomas. J Pediatr Hematol Oncol 19: pp. 93-101 CrossRef
- Schwab, M (2004) MYCN in neuronal tumours. Cancer Lett 204: pp. 179-187 CrossRef
- Shapiro, DN, Valentine, MB, Rowe, ST (1993) Detection of N-myc gene amplification by fluorescence in situ hybridization: diagnostic utility for neuroblastoma. Am J Pathol 142: pp. 1339-1346
- Brodeur, GM, Castleberry, RP Neuroblastoma. In: Pizzo, PA, Poplack, DG eds. (1993) Principles and Practice of Pediatric Oncology. JB Lippincott Company, Philadelphia, PA, pp. 739-768
- Rothman, KJ, Greeland, S (1998) Modern Epidemiology. Lippincott Williams & Wilkins, Philadelphia, PA
- Infante-Rivard, C, Jacques, L (2000) Empirical study of parental recall bias. Am J Epidemiol 152: pp. 480-486
- Schuz, J, Spector, LG, Ross, JA (2003) Bias in studies of parental self-reported occupational exposure and childhood cancer. Am J Epidemiol 158: pp. 710-716 CrossRef
- Drews, CD, Kraus, JF, Greenland, S (1990) Recall bias in a case–control study of sudden infant death syndrome. Int J Epidemiol 19: pp. 405-411
- Maternal hair dye use and risk of neuroblastoma in offspring*
Cancer Causes & Control
Volume 16, Issue 6 , pp 743-748
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- hair dyes
- case–control studies.
- Industry Sectors