Skip to main content

Advertisement

SpringerLink
Log in

Diagnostic utility of mammaglobin and GCDFP-15 in the identification of primary neuroendocrine carcinomas of the breast

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. WHO (2003) World Health Organization classification of tumors. In: Tavassoli FA, Devilee P (eds) Pathology and genetics of tumours of the breast and female genital organs. IARC Press, Lyib, pp 9–112

    Google Scholar 

  2. Günhan-Bilgen I, Zekioglu O, Ustün EE, Memis A, Erhan Y (2003) Neuroendocrine differentiated breast carcinoma: imaging features correlated with clinical and histopathological findings. Eur Radiol 13:788–793

    PubMed  Google Scholar 

  3. Kawasaki T, Nakamura S, Sakamoto G et al (2010) Neuroendocrine ductal carcinoma in situ of the breast: cytological features in 32 cases. Cytopathology. (Epub ahead)

  4. Righi L, Sapino A, Marchiò C, Papotti M, Bussolati G (2010) Neuroendocrine differentiation in breast cancer: established facts and unresolved problems. Semin Diagn Pathol 27:69–76

    Article  PubMed  Google Scholar 

  5. Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752

    Article  CAS  PubMed  Google Scholar 

  6. Weigelt B, Geyer FC, Horlings HM et al (2009) Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type. Mod Pathol 22:1401–1414

    Article  CAS  PubMed  Google Scholar 

  7. Richter-Ehrenstein C, Arndt J, Buckendahl AC et al (2010) Solid neuroendocrine carcinomas of the breast: metastases or primary tumors? Breast Cancer Res Treat 124:413–417

    Article  CAS  PubMed  Google Scholar 

  8. Lopez-Bonet E, Alonso-Ruano M, Barraza G et al (2008) Solid neuroendocrine breast carcinomas: incidence, clinico-pathological features and immunohistochemical profiling. Oncol Rep 20:1369–1374

    PubMed  Google Scholar 

  9. Bhargava R, Beriwal S, Dabbs DJ (2007) Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 27:103–113

    Article  Google Scholar 

  10. Carey LA, Perou CM, Livasy CA et al (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295:2492–2502

    Article  CAS  PubMed  Google Scholar 

  11. Caputo E, Manco G, Mandrich L, Guardiola J (2000) A novel aspartyl proteinase from apocrine epithelia and breast tumors. J Biol Chem 275:7935–7941

    Article  CAS  PubMed  Google Scholar 

  12. Sapino A, Righi L, Cassoni P et al (2001) Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women. Mod Pathol 14:768–776

    Article  CAS  PubMed  Google Scholar 

  13. Honma N, Takubo K, Akiyama F et al (2005) Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. Histopathology 47:195–201

    Article  CAS  PubMed  Google Scholar 

  14. Esparís-Ogando A, Ocaña A, Rodríguez-Barrueco R et al (2008) Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells. Ann Oncol 19:1860–1869

    Article  PubMed  Google Scholar 

  15. Bhargava R, Beriwal S, Striebel JM, Dabbs DJ (2010) Breast cancer molecular class ERBB2: preponderance of tumors with apocrine differentiation and expression of basal phenotype markers CK5, CK5/6, and EGFR. Appl Immunohistochem Mol Morphol 18:113–118

    Article  CAS  PubMed  Google Scholar 

  16. Vranic S, Tawfik O, Palazzo J et al (2010) EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breast. Mod Pathol 23:644–653

    Article  CAS  PubMed  Google Scholar 

  17. Wei B, Ding T, Xing Y et al (2010) Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma. Cancer 116:4463–4473

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported in part by the Xarxa de Banc de Tumors de Catalunya (XBTC) sponsored by the Pla Director d’Oncologia de Catalunya. Alejandro Vazquez-Martin is the recipient of a “Sara Borrell” post-doctoral contract (CD08/00283, Ministerio de Sanidad y Consumo, Fondo de Investigación Sanitaria –FIS-, Spain). Work at Menendez’ laboratory is supported in part by the Instituto de Salud Carlos III (Ministerio de Sanidad y Consumo, Fondo de Investigación Sanitaria–FIS-, Spain, Grants CP05-00090 and PI06-0778 and RD06-0020-0028), the Fundación Científica de la Asociación Española Contra el Cáncer (AECC, Spain), and by the Ministerio de Ciencia e Innovación (SAF2009-11579, Plan Nacional de I + D + I, MICINN, Spain).

Author information

Authors and Affiliations

  1. Department of Anatomical Pathology, Dr. Josep Trueta University Hospital, Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Eugeni Lopez-Bonet, Maria Carmen Pérez-Martínez & Luis Bernadó

  2. Department of Pathology, Autonomous University of Barcelona School of Medicine (UAB), Campus de la UAB Bellaterra, E-08193, Barcelona, Catalonia, Spain

    Eugeni Lopez-Bonet

  3. Girona Biomedical Research Institute (IdIBGi), Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Eugeni Lopez-Bonet, Maria Carmen Pérez-Martínez, Begoña Martin-Castillo, Miguel Alonso-Ruano, Francesc Tuca, Cristina Oliveras-Ferraros, Sílvia Cufí, Alejandro Vazquez-Martin, Miquel Beltràn, Luis Bernadó & Javier A. Menendez

  4. Unit of Clinical Research, Catalan Institute of Oncology-Girona (ICO-Girona), Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Begoña Martin-Castillo

  5. Department of Gynaecology, Dr. Josep Trueta University Hospital, Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Miguel Alonso-Ruano & Francesc Tuca

  6. Unit of Translational Research, Catalan Institute of Oncology-Girona (ICO-Girona), Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Cristina Oliveras-Ferraros, Sílvia Cufí, Alejandro Vazquez-Martin & Javier A. Menendez

  7. Medical Oncology, Catalan Institute of Oncology-Girona (ICO-Girona), Avenida de Francia s/n, E-17007, Girona, Catalonia, Spain

    Miquel Beltràn

  8. Catalan Institute of Oncology Girona (ICO-Girona), Dr. Josep Trueta University Hospital, Avenida de França s/n, E-17007, Girona, Catalonia, Spain

    Javier A. Menendez

Authors
  1. Eugeni Lopez-Bonet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Carmen Pérez-Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Begoña Martin-Castillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Miguel Alonso-Ruano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Francesc Tuca
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cristina Oliveras-Ferraros
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sílvia Cufí
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alejandro Vazquez-Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Miquel Beltràn
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Luis Bernadó
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Javier A. Menendez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Javier A. Menendez.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lopez-Bonet, E., Pérez-Martínez, M.C., Martin-Castillo, B. et al. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of primary neuroendocrine carcinomas of the breast. Breast Cancer Res Treat 126, 241–245 (2011). https://doi.org/10.1007/s10549-010-1229-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-010-1229-9

Keywords

Search

Navigation