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Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population

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Abstract

Essential hypertension is a complex multifactorial disease caused by interactions between genetic and environmental factors. It is an independent determinant of cardiovascular risk. The main aim of this study was to investigate the possible influence of angiotensinogen M268T polymorphisms on hypertension in two endogamous caste populations of South India. Systolic and diastolic blood pressure, anthropometric variables, and lipid profiles were assessed. Direct sequencing of PCR products was adopted for genotyping. This polymorphism was found to be in Hardy–Weinberg equilibrium in the patients and controls of both populations. Binary odds ratios showed significant association between the M268T polymorphism and hypertension in both populations. Multivariate analysis revealed significant differences in body mass index, chest girth, calf circumference, skinfold measurements, total cholesterol, and triglyceride levels between these genotypes in the Gavara and Vaishya populations. These data further support the hypothesis that hypertension is influenced by the AGT M268T polymorphism.

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Acknowledgments

This research study was supported by the Anthropological Survey of India, Ministry of Culture, Government of India.

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Authors and Affiliations

  1. Anthropological Survey of India, Government of India, Ministry of Culture, Kolkata, India

    M. Gopi Chand, J. Srinath & Satish Kumar

  2. Department of Anthropology, Andhra University, Vishakhapatnam, India

    M. Gopi Chand & R. S. Rao

  3. Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India

    Bhaskar V. K. S. Lakkakula

  4. Department of Anthropology, Delhi University, North Campus, Delhi, 110 007, India

    V. R. Rao

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  1. M. Gopi Chand
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  2. J. Srinath
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  3. R. S. Rao
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  4. Bhaskar V. K. S. Lakkakula
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  5. Satish Kumar
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  6. V. R. Rao
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Correspondence to V. R. Rao.

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Gopi Chand, M., Srinath, J., Rao, R.S. et al. Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population. Biochem Genet 49, 474–482 (2011). https://doi.org/10.1007/s10528-011-9423-y

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  • DOI: https://doi.org/10.1007/s10528-011-9423-y

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