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Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension

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Abstract

We studied the effects of antioxidants resveratrol and pQ510 on physiological parameters and the state of endothelial NO-synthase as a marker of the regulatory function of the endothelium in the aorta of rats with modeled arterial hypertension. The antioxidants promoted recovery of stable NO metabolites in rat serum and maintained expression of endothelial NO-synthase at a normal level. These effects were confirmed by correction of blood pressure and endothelium-dependent vascular dilation assessed by endothelial dysfunction coefficient.

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Authors and Affiliations

  1. State Research Institute of Preventive Medicine, Ministry of Health of the Russian Federation, Moscow

    N. G. Gumanova & V. A. Metel’skaya

  2. Kursk State Medical University, Federal Agency for Health Care and Social Development, Kursk

    E. B. Artyushkova, V. I. Kochkarov, T. G. Pokrovskaya, L. M. Danilenko, M. M. Korneev, M. V. Pokrovskii & E. N. Pashin

Authors
  1. N. G. Gumanova
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  2. E. B. Artyushkova
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  3. V. A. Metel’skaya
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  4. V. I. Kochkarov
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  5. T. G. Pokrovskaya
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  6. L. M. Danilenko
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  7. M. M. Korneev
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  8. M. V. Pokrovskii
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  9. E. N. Pashin
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 619–622, June, 2007

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Gumanova, N.G., Artyushkova, E.B., Metel’skaya, V.A. et al. Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension. Bull Exp Biol Med 143, 678–681 (2007). https://doi.org/10.1007/s10517-007-0212-x

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  • DOI: https://doi.org/10.1007/s10517-007-0212-x

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