Japanese Journal of Ophthalmology

, Volume 54, Issue 6, pp 571–577

Predictors of response after intravitreal bevacizumab injection for neovascular age-related macular degeneration

Clinical Investigation

DOI: 10.1007/s10384-010-0866-1

Cite this article as:
Byun, Y.J., Lee, S.J. & Koh, H.J. Jpn J Ophthalmol (2010) 54: 571. doi:10.1007/s10384-010-0866-1



To identify fluorescein angiography (FA) and optical coherence tomography (OCT) characteristics predicting responses to intravitreal bevacizumab therapy in patients with neovascular age-related macular degeneration (AMD).


Results of 113 consecutive patients (113 eyes) treated with intravitreal bevacizumab injections for neovascular AMD were retrospectively reviewed. Patients were categorized into two groups according to visual acuity (VA) improvement 1 year after treatment: responders and nonresponders. Responders were defined as patients who achieved VA improvement ≥7 Early Treatment Diabetic Retinopathy Study (ETDRS) letters for occult choroidal neovascularization (CNV), and ≥11 ETDRS letters for classic CNV at month 12. N onresponders were defined as patients who did not meet the above VA improvement at month 12.


Of the 113 eyes, 36 (31.9%) were categorized as responders and 77 (68.1%) as nonresponders. Nonresponders, compared with responders, had thicker subretinal tissue (SRT) (218.9 μm versus 180.9 μm, P = 0.040), and more frequent cystoid macular edema (CME) (42.9% versus 13.9%, P < 0.001).


Thick SRT and CME on OCT may be characteristic of nonresponders and may be helpful for tailoring treatment for neovascular AMD.



Copyright information

© Japanese Ophthalmological Society (JOS) 2010

Authors and Affiliations

  • Yeo Jue Byun
    • 1
  • Sung Jun Lee
    • 2
  • Hyoung Jun Koh
    • 1
    • 3
  1. 1.Institute of Vision Research, Department of OphthalmologyYonsei University College of MedicineSeoulKorea
  2. 2.Department of Ophthalmology, Dongguk University Ilsan HospitalDongguk University School of MedicineGyeonggidoKorea
  3. 3.Department of OphthalmologyYonsei University College of MedicineSeoulKorea