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Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

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Abstract

Object

To determine the single spin-echo T 2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T.

Materials and methods

Measurements were performed on five rats at 14.1 T using the SPECIAL sequence and TE-specific basis-sets for LCModel analysis.

Results and conclusion

The T 2 of singlets ranged from 98 to 148 ms and T 2 of J-coupled metabolites ranged from 72 ms (glutamate) to 97 ms (myo-inositol). When comparing the T 2s of the metabolites measured at 14.1 T with those previously measured at 9.4 T, a decreasing trend was found (p < 0.0001). We conclude that the modest shortening of T 2 at 14.1 T has a negligible impact on the sensitivity of the 1H MRS when performed at TE shorter than 10 ms.

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Abbreviations

tCho:

Total choline (glycerophosphorylcholine + phosphorylcholine)

tCr:

Total creatine (phosphocreatine + creatine)

Cr:

Creatine

GSH:

Glutathione

Glu:

Glutamate

Ins:

Myo-inositol

NAA:

N-acetylaspartate

Tau:

Taurine

VOI:

Volume of interest

SPECIAL:

SPin ECho, full Intensity Acquired Localized spectroscopy

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Acknowledgments

This study was supported by Centre d’Imagerie BioMédicale (CIBM) of the UNIL, UNIGE, HUG, CHUV, EPFL, the Leenaards and Jeantet Foundations.

Author information

Authors and Affiliations

  1. Departments of Radiology, University of Lausanne, Lausanne, Switzerland

    Lijing Xin & Rolf Gruetter

  2. Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Cristina Cudalbu, Vladimír Mlynárik & Rolf Gruetter

  3. Departments of Radiology, University of Geneva, Geneva, Switzerland

    Rolf Gruetter

  4. INSERM, U1099, 35000, Rennes, France

    Giulio Gambarota

  5. LTSI, Université de Rennes 1, 35000, Rennes, France

    Giulio Gambarota

  6. Ecole Polytechnique Fédérale de Lausanne (EPFL), EPFL-SB-IPSB-LIFMET, Station 6, 1015, Lausanne, Switzerland

    Lijing Xin

Authors
  1. Lijing Xin
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  2. Giulio Gambarota
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  3. Cristina Cudalbu
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  4. Vladimír Mlynárik
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  5. Rolf Gruetter
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Corresponding author

Correspondence to Lijing Xin.

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Xin, L., Gambarota, G., Cudalbu, C. et al. Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain. Magn Reson Mater Phy 26, 549–554 (2013). https://doi.org/10.1007/s10334-013-0378-3

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  • DOI: https://doi.org/10.1007/s10334-013-0378-3

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