Abstract
In our work, we investigated thyroid and cardiac MIBG uptake as potential differential markers. We observed reduced cardiac uptake of MIBG in PD and diabetic CAN, in agreement with the previous studies. However, there was a significant difference between the PD and diabetic cardiac autonomic neuropathy groups with respect to early and delayed thyroid MIBG uptake, in that reduced thyroid MIBG uptake was seen in PD but not in diabetic autonomic neuropathy. We therefore propose that this parameter could be a marker for identifying parkinsonism when it presents together with DM.
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References
Rascol O, Schelosky L (2009) 123I-metaiodobenzylguanidine scintigraphy in Parkinson’s disease and related disorders. Mov Disord 24:S732–S741
Hirayama MHS, Koike Y, Ito K, Kato T, Ikeda M, Hasegawa Y, Takahashi A (1995) A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure. J Auton Nerv Syst 25:230–234
Scott LA, Kench PL (2004) Cardiac autonomic neuropathy in the diabetic patient: does 123I-MIBG imaging have a role to play in early diagnosis? J Nucl Med Technol 32:66–71
Matsui H, Udaka F, Oda M, Kubori T, Nishinaka K, Kameyama M (2005) Metaiodobenzylguanidine (MIBG) scintigraphy at various parts of the body in Parkinson’s disease and multiple system atrophy. Auton Neurosci 119:56–60
Matsui H, Udaka F, Oda M, Tamura A, Kubori T, Nishinaka K, Kameyama M (2005) Metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease also decreases at thyroid. Ann Nucl Med 19:225–229
Taki J, Nakajima K, Hwang E-H, Matsunari I, Komai K, Yoshita M, Sakajiri K, Tonami N (2000) Peripheral sympathetic dysfunction in patients with Parkinson’s disease without autonomic failure is heart selective and disease specific. Eur J Nucl Med Mol Imaging 27:566–573
Holmberg B, Kallio M, Johnels B, Elam M (2001) Cardiovascular reflex testing contributes to clinical evaluation and differential diagnosis of Parkinsonian syndromes. Mov Disord 16:217–225
Scholte A, Schuijf J, Delgado V, Kok J, Bus M, Maan A, Stokkel M, Kharagitsingh A, Dibbets-Schneider P, van der Wall E, Bax J (2010) Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I metaiodobenzylguanidine myocardial scintigraphy and heart rate variability. Eur J Nucl Med 37:1698–1705
Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li S-T (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58:1247–1255
Hage M, Zantout MS, Azar ST (2011) Thyroid disorders and diabetes mellitus. J Thyroid Res 2011:439463
Acknowledgments
This work was supported by a grant from the Korean Health Technology R and D Project, Ministry for Health Welfare and Family Affairs, Republic of Korea (A101712).
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Jang, W., Kim, JS., Cho, J.W. et al. Thyroid MIBG uptake in Parkinson’s disease with diabetes mellitus. Clin Auton Res 23, 221–224 (2013). https://doi.org/10.1007/s10286-013-0204-z
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DOI: https://doi.org/10.1007/s10286-013-0204-z