International Journal of Clinical Oncology

, Volume 20, Issue 2, pp 375–385

Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS)

  • Shiro Saito
  • Kazuto Ito
  • Atsunori Yorozu
  • Manabu Aoki
  • Hirofumi Koga
  • Takefumi Satoh
  • Toshio Ohashi
  • Naoyuki Shigematsu
  • Shinichiro Maruo
  • Takashi Kikuchi
  • Shinsuke Kojima
  • Takushi Dokiya
  • Masanori Fukushima
  • Hidetoshi Yamanaka
Original Article

DOI: 10.1007/s10147-014-0704-4

Cite this article as:
Saito, S., Ito, K., Yorozu, A. et al. Int J Clin Oncol (2015) 20: 375. doi:10.1007/s10147-014-0704-4

Abstract

Background

To evaluate the safety and efficacy of brachytherapy with permanent iodine-125 seed implantation (PI) for prostate cancer. The nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) has continued since July 2005. This manuscript presents the rationale, J-POPS study design, and the characteristics of initial participants enrolled in this study from July 2005 to June 2007.

Methods

All participants were treated with PI in accordance with the American Brachytherapy Society recommendations. The primary outcome measure was biochemical progression-free survival. Progression-free survival, overall survival, cause-specific survival, longitudinal changes in health-related quality of life, disease-specific quality of life, the International Prostate Symptom Score, and the incidence of adverse events were also investigated as secondary outcome measurements.

Results

Overall, 6,927 patients were enrolled by the end of 2010, that is approximately 40 % of all cases treated around the country. During the first 2 years, 2,354 participants were enrolled and 2,339 were actually treated with PI. The age range of participants was 45 to 89 years (median 69 years) and their risk classifications were 1,037 (44.3 %) at low risk, 1,126 (48.1 %) at intermediate risk, and 134 (5.7 %) at high risk, in addition to 16 participants whose classification was unknown. Of all patients, 76.6 % were treated with PI without external beam radiation therapy and 49.3 % received neoadjuvant hormone therapy.

Conclusions

The J-POPS, a nationwide prospective cohort study that enrolled approximately 40 % of all PI cases in Japan, will provide highly reliable evidence, including outcomes and quality of life, after long-term follow-up.

Keywords

BrachytherapyIodine-125Multi-institutional prospective cohort studyProstate cancer

Copyright information

© Japan Society of Clinical Oncology 2014

Authors and Affiliations

  • Shiro Saito
    • 1
  • Kazuto Ito
    • 2
  • Atsunori Yorozu
    • 3
  • Manabu Aoki
    • 4
  • Hirofumi Koga
    • 5
  • Takefumi Satoh
    • 6
  • Toshio Ohashi
    • 7
  • Naoyuki Shigematsu
    • 7
  • Shinichiro Maruo
    • 8
  • Takashi Kikuchi
    • 8
  • Shinsuke Kojima
    • 8
  • Takushi Dokiya
    • 9
  • Masanori Fukushima
    • 8
  • Hidetoshi Yamanaka
    • 10
  1. 1.Department of UrologyNational Hospital Organization Tokyo Medical CenterTokyoJapan
  2. 2.Department of UrologyGunma UniversityGunmaJapan
  3. 3.Department of Radiation OncologyNational Hospital Organization Tokyo Medical CenterTokyoJapan
  4. 4.Department of Radiation OncologyJikei University School of MedicineTokyoJapan
  5. 5.Department of UrologyHara Sanshin HospitalFukuokaJapan
  6. 6.Department of UrologyKitasato University School of MedicineKanagawaJapan
  7. 7.Department of Radiation OncologyKeio University School of MedicineTokyoJapan
  8. 8.Translational Research Informatics CenterHyogoJapan
  9. 9.Department of Radiation OncologySaitama Medical CollegeSaitamaJapan
  10. 10.Institutes of Preventive MedicineKurosawa HospitalGunmaJapan