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Do oral contraceptives act as mood stabilizers? Evidence of positive affect stabilization

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Summary

Previous research has suggested that oral contraceptives (OCs) may provide a stabilizing effect on affect. The present study examined whether OC users and nonusers differ in their affect reactivity in response to four laboratory mood induction procedures. A sample of 107 undergraduate students (40 OC users, 36 nonusers, and 31 men) completed the Positive and Negative Affect Schedule (PANAS) before and after completing a series of four mood-induction procedures (i.e., positive affect, jealousy, social ostracism, and parental feelings affect inductions). OC users experienced a blunted positive affect response to the tasks when compared with nonusers and men. Women who used OCs for less than two years showed the lowest positive affect reactivity. The groups did not differ in terms of negative affect reactivity. The results suggest that hormonal contraceptives may reduce the degree of positive affect change that women experience in response to environmental events. Possible mechanisms for an OC-induced positive affect stabilization effect are discussed.

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References

  • S Abraham G Luscombe I Soo (2003) ArticleTitleOral contraception and cyclic changes in premenstrual and menstrual experiences J Psychosom Obstet Gynecol 24 185–193 Occurrence Handle1:STN:280:DC%2BD3srgvVeltg%3D%3D

    CAS  Google Scholar 

  • M Almagor YS Ben-Porath (1991) ArticleTitleMood changes during the menstrual cycle and their relation to the use of oral contraceptives J Psychosom Res 35 721–728 Occurrence Handle1791586 Occurrence Handle10.1016/0022-3999(91)90123-6 Occurrence Handle1:STN:280:DyaK387mslWgtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • InstitutionalAuthorNameAmerican Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders EditionNumberrevised 4 American Psychiatric Association Washington, DC

    Google Scholar 

  • A Bonen FW Haynes TE Graham (1991) ArticleTitleSubstrate and hormonal responses to exercise in women using oral contraceptives J Appl Physiol 70 1917–1927 Occurrence Handle1864771 Occurrence Handle1:CAS:528:DyaK3MXkt1ansLg%3D

    PubMed  CAS  Google Scholar 

  • G Boyle A Grant (1992) ArticleTitleProspective versus retrospective assessment of menstrual cycle symptoms and moods: role of attitudes and beliefs J Psychopathol Behav Assess 14 307–321 Occurrence Handle10.1007/BF00960776

    Article  Google Scholar 

  • TW Buchanan M al’Absi WR Lovallo (1999) ArticleTitleCortisol fluctuates with increases and decreases in negative affect Psychoneuroendocrinology 24 227–241 Occurrence Handle10101730 Occurrence Handle10.1016/S0306-4530(98)00078-X Occurrence Handle1:CAS:528:DyaK1MXhsl2itrg%3D

    Article  PubMed  CAS  Google Scholar 

  • DM Buss RJ Larsen D Westen J Semmelroth (1992) ArticleTitleSex differences in jealousy: evolution, physiology, and psychology Psychol Sci 3 251–255 Occurrence Handle10.1111/j.1467-9280.1992.tb00038.x

    Article  Google Scholar 

  • G Chouinard S Steinberg W Steiner (1987) ArticleTitleEstrogen-progesterone combination: another mood stabilizer? Am J Psychiatry 144 826 Occurrence Handle3592013 Occurrence Handle1:STN:280:DyaL2s3jvFSnsA%3D%3D

    PubMed  CAS  Google Scholar 

  • L Clark D Watson (1991) ArticleTitleTripartite model of anxiety and depression: psychometric evidence and taxonomic implications J Abnorm Psychol 100 316–336 Occurrence Handle1918611 Occurrence Handle10.1037/0021-843X.100.3.316 Occurrence Handle1:STN:280:DyaK38%2Fht1GgtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • A Clark D Watson J Leeka (1989) ArticleTitleDiurnal variation in the positive affects Motiv Emot 13 205–234 Occurrence Handle10.1007/BF00995536

    Article  Google Scholar 

  • J Cullberg (1972) ArticleTitleMood changes and menstrual symptoms with different gestagen/estrogen combinations Acta Psychiatr Scand 236 1–86 Occurrence Handle1:STN:280:DyaE3s%2Fls1eruw%3D%3D

    CAS  Google Scholar 

  • J Denollet J De Vries (2006) ArticleTitlePositive and negative affect within the realm of depression, stress, and fatigue: the two-factor distress model of the Global Mood Scale (GMS) J Affect Disord 91 171–180 Occurrence Handle16458366 Occurrence Handle10.1016/j.jad.2005.12.044

    Article  PubMed  Google Scholar 

  • NI Eisenberger MD Lieberman KP Williams (2003) ArticleTitleDoes rejection hurt? An fMRI study of social exclusion Science 302 290–292 Occurrence Handle14551436 Occurrence Handle10.1126/science.1089134 Occurrence Handle1:CAS:528:DC%2BD3sXnvFWgtLk%3D

    Article  PubMed  CAS  Google Scholar 

  • WA Fisher R Boroditsky ML Bridges (1999) ArticleTitleThe 1998 Canadian Contraception Study Can J Hum Sex 8 161–226

    Google Scholar 

  • P Follesa P Porcu C Sogliano M Cinus F Biggio L Mancuso MC Mostallino AM Paoletti RH Purdy G Biggio A Concas (2002) ArticleTitleChanges in GABAA receptor γ2 subunit gene expression induced by long-term administration of oral contraceptives in rats Neuropharmacology 42 325–336 Occurrence Handle11897111 Occurrence Handle10.1016/S0028-3908(01)00187-3 Occurrence Handle1:CAS:528:DC%2BD38XhvVCjs7g%3D

    Article  PubMed  CAS  Google Scholar 

  • EE Forbes RE Dahl (2005) ArticleTitleNeural systems of positive affect: relevance to understanding child and adolescent depression? Dev Psychopathol 17 827–850 Occurrence Handle16262994

    PubMed  Google Scholar 

  • A Gerrards-Hesse K Spies FW Hesse (1994) ArticleTitleExperimental inductions of emotional states and their effectiveness: a review Br J Psychol 85 55–78

    Google Scholar 

  • CA Graham BB Sherwin (1993) ArticleTitleThe relationship between mood and sexuality in women using an oral contraceptive as a treatment for premenstrual symptoms Psychoneuroendocrinology 18 273–281 Occurrence Handle8316616 Occurrence Handle10.1016/0306-4530(93)90024-F Occurrence Handle1:STN:280:DyaK3szgtlamsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • WH James (2005) ArticleTitleBiological and psychosocial determinants of male and female human sexual orientation J Biosoc Sci 37 555–567 Occurrence Handle16174346 Occurrence Handle10.1017/S0021932004007059

    Article  PubMed  Google Scholar 

  • C Kirschbaum KM Pirke DH Hellhammer (1995) ArticleTitlePreliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication Psychoneuroendocrinology 20 509–514 Occurrence Handle7675935 Occurrence Handle10.1016/0306-4530(94)00078-O Occurrence Handle1:STN:280:DyaK2Mvgs1elug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • C Kirschbaum P Platte KM Pirke DH Hellhammer (1996) ArticleTitleAdrenocortical activation following stressful exercise: further evidence for attenuated free cortisol responses in women using oral contraceptives Stress Med 12 137–143 Occurrence Handle10.1002/(SICI)1099-1700(199607)12:3<137::AID-SMI685>3.0.CO;2-C

    Article  Google Scholar 

  • C Kirschbaum BM Kudielka J Gaab NC Schommer DH Hellhammer (1999) ArticleTitleImpact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis Psychosom Med 61 154–162 Occurrence Handle10204967 Occurrence Handle1:STN:280:DyaK1M3hvFOjsA%3D%3D

    PubMed  CAS  Google Scholar 

  • S Kuhlmann OT Wolf (2005) ArticleTitleCortisol and memory retrieval in women: Influence of menstrual cycle and oral contraceptives Psychopharmacology 183 65–71 Occurrence Handle16133131 Occurrence Handle10.1007/s00213-005-0143-z Occurrence Handle1:CAS:528:DC%2BD2MXhtFemurrP

    Article  PubMed  CAS  Google Scholar 

  • N Kurshan CN Epperson (2006) ArticleTitleOral contraceptives and mood in women with and without premenstrual dysphoria: a theoretical model Arch Womens Ment Health 9 1–14 Occurrence Handle16206030 Occurrence Handle10.1007/s00737-005-0102-z Occurrence Handle1:STN:280:DC%2BD28%2FhvFyhsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • S Kutner W Brown (1972) ArticleTitleTypes of oral contraceptives, depression, and premenstrual symptoms J Nerv Ment Dis 155 153–162 Occurrence Handle4403361 Occurrence Handle1:STN:280:DyaE383mt1Wjuw%3D%3D Occurrence Handle10.1097/00005053-197209000-00001

    Article  PubMed  CAS  Google Scholar 

  • T Long RG Kathol (1993) ArticleTitleCritical review of data supporting affective disorder caused by nonpsychotropic medicine Ann Clin Psychiatry 5 259–270 Occurrence Handle7906178 Occurrence Handle1:STN:280:DyaK2c7ks1yrtw%3D%3D Occurrence Handle10.3109/10401239309148826

    Article  PubMed  CAS  Google Scholar 

  • J McFarlane C Martin T Williams (1988) ArticleTitleMood fluctuations: women versus men and menstrual versus other cycles Psychol Wom Q 12 201–223 Occurrence Handle10.1111/j.1471-6402.1988.tb00937.x

    Article  Google Scholar 

  • G Murray NB Allen J Trinder (2002) ArticleTitleMood and the circadian system: investigation of a circadian component in positive affect Chronobiol Int 19 1151–1169 Occurrence Handle12511032 Occurrence Handle10.1081/CBI-120015956

    Article  PubMed  Google Scholar 

  • JL Nandrino V Dodin P Martin M Henniaux (2004) ArticleTitleEmotional information processing in first and recurrent depressive episodes J Psychiatr Res 38 475–484 Occurrence Handle15380397 Occurrence Handle10.1016/j.jpsychires.2004.03.002

    Article  PubMed  Google Scholar 

  • Oinonen KA, Jarva JA (2006) Pre-existing hormonal differences between oral contraceptive users and nonusers? Evidence from age of menarche, and sociosexual orientation. Unpublished manuscript

  • KA Oinonen D Mazmanian (2001) ArticleTitleEffects of oral contraceptives on daily self-ratings of positive and negative affect J Psychosom Res 51 1–12 Occurrence Handle10.1016/S0022-3999(01)00240-9

    Article  Google Scholar 

  • KA Oinonen D Mazmanian (2002) ArticleTitleTo what extent do oral contraceptives influence mood and affect? J Affect Disord 70 229–240 Occurrence Handle12128235 Occurrence Handle10.1016/S0165-0327(01)00356-1 Occurrence Handle1:CAS:528:DC%2BD38XlsVOru7o%3D

    Article  PubMed  CAS  Google Scholar 

  • MA Ott MA Sayegh ML Shew JD Fortenberry (2005) ArticleTitleOral contraceptive pills and mood in adolescents J Adolesc Health 36 144 Occurrence Handle10.1016/j.jadohealth.2004.11.101

    Article  Google Scholar 

  • KE Paige (1971) ArticleTitleEffects of oral contraceptives on affective fluctuations associated with the menstrual cycle Psychosom Med 33 515–537 Occurrence Handle5148982 Occurrence Handle1:STN:280:DyaE387oslOkug%3D%3D

    PubMed  CAS  Google Scholar 

  • DE Polk S Cohen WJ Doyle DP Skoner C Kirschbaum (2005) ArticleTitleState and trait affect as predictors of salivary cortisol in healthy adults Psychoneuroendocrinology 30 261–272 Occurrence Handle15511600 Occurrence Handle10.1016/j.psyneuen.2004.08.004 Occurrence Handle1:CAS:528:DC%2BD2cXptFKqsLw%3D

    Article  PubMed  CAS  Google Scholar 

  • SD Pressman S Cohen (2005) ArticleTitleDoes positive affect influence health? Psychol Bull 131 925–971 Occurrence Handle16351329 Occurrence Handle10.1037/0033-2909.131.6.925

    Article  PubMed  Google Scholar 

  • Q Rahman (2005) ArticleTitleThe neurodevelopment of human sexual orientation Neurosci Biobehav Rev 29 1057–1066 Occurrence Handle16143171 Occurrence Handle10.1016/j.neubiorev.2005.03.002

    Article  PubMed  Google Scholar 

  • AJ Rapkin M Morgan C Sogliano G Biggio A Concas (2006) ArticleTitleDecreased neuroactive steroids induced by combined oral contraceptive pills are not associated with mood changes Fertil Steril 85 1371–1378 Occurrence Handle16580672 Occurrence Handle10.1016/j.fertnstert.2005.10.031

    Article  PubMed  Google Scholar 

  • N Rasgon M Bauer T Glenn S Elman PC Whybrow (2003) ArticleTitleMenstrual cycle related mood changes in women with bipolar disorder Bipolar Disord 5 48–52 Occurrence Handle12656938 Occurrence Handle10.1034/j.1399-5618.2003.00010.x

    Article  PubMed  Google Scholar 

  • N Rohleder JM Wolf M Piel C Kirschbaum (2003) ArticleTitleImpact of oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychological stress Psychoneuroendocrinology 28 261–273 Occurrence Handle12573295 Occurrence Handle10.1016/S0306-4530(02)00019-7 Occurrence Handle1:CAS:528:DC%2BD3sXotlOmsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • MJ Rosenberg MS Waugh (1998) ArticleTitleOral contraceptive discontinuation: a prospective evaluation of frequency and reasons Am J Obstet Gynecol 179 577–582 Occurrence Handle9757954 Occurrence Handle10.1016/S0002-9378(98)70047-X Occurrence Handle1:STN:280:DyaK1cvivV2hsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • R Sabatini R Cagiano (2006) ArticleTitleComparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives Contraception 74 220–223 Occurrence Handle16904415 Occurrence Handle10.1016/j.contraception.2006.03.022

    Article  PubMed  Google Scholar 

  • SA Sanders CA Graham JL Bass J Bancroft (2001) ArticleTitleA prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation Contraception 64 51–58 Occurrence Handle11535214 Occurrence Handle10.1016/S0010-7824(01)00218-9 Occurrence Handle1:STN:280:DC%2BD3Mvpt12rsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • S Silbergeld N Brast E Noble (1971) ArticleTitleThe menstrual cycle: a double-blind study of symptoms, mood and behaviour, and biochemical variables using Enovid and placebo Psychosom Med 33 411–428 Occurrence Handle4942289 Occurrence Handle1:CAS:528:DyaE38XksFKqtLc%3D

    PubMed  CAS  Google Scholar 

  • JA Simpson SW Gangestad (1991) ArticleTitleIndividual differences in sociosexuality: evidence for convergent and discriminant validity J Pers Soc Psychol 60 870–883 Occurrence Handle1865325 Occurrence Handle10.1037/0022-3514.60.6.870 Occurrence Handle1:STN:280:DyaK3MzisFSnug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • J Smyth MC Ockenfels L Porter C Kirschbaum DH Hellhammer AA Stone (1998) ArticleTitleStressors and mood measured on a momentary basis are associated with salivary cortisol secretion Psychoneuroendocrinology 23 353–370 Occurrence Handle9695136 Occurrence Handle10.1016/S0306-4530(98)00008-0 Occurrence Handle1:STN:280:DyaK1czmtVanuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • PB Sutker JM Libet AN Allain CL Randall (1983) ArticleTitleAlcohol use, negative mood states, and the menstrual cycle phases Alcohol Clin Exp Res 7 327–331 Occurrence Handle6353985 Occurrence Handle1:STN:280:DyaL2c%2FitFKksw%3D%3D

    PubMed  CAS  Google Scholar 

  • A Walker J Bancroft (1990) ArticleTitleRelationship between premenstrual symptoms and oral contraceptive use: a controlled study Psychosom Med 52 86–96 Occurrence Handle2305025 Occurrence Handle1:STN:280:DyaK3c7mtFSjtg%3D%3D

    PubMed  CAS  Google Scholar 

  • P Warner J Bancroft (1988) ArticleTitleMood, sexuality, oral contraceptives and the menstrual cycle J Psychosom Res 32 417–427 Occurrence Handle3236269 Occurrence Handle10.1016/0022-3999(88)90025-6 Occurrence Handle1:STN:280:DyaL1M7nvVagug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Watson D, Clark LA (1994) Manual for the positive and negative affect schedule – expanded form. (unpublished manuscript)

  • D Watson LA Clark A Tellegen (1988) ArticleTitleDevelopment and validation of brief measures of positive and negative affect: the PANAS scales J Pers Soc Psychol 54 1063–1070 Occurrence Handle3397865 Occurrence Handle10.1037/0022-3514.54.6.1063 Occurrence Handle1:STN:280:DyaL1c3os1ersA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SG West CM Stoney JW Hughes M Matacin KM Emmons (2001) ArticleTitleOral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers Ann Behav Med 23 149–157 Occurrence Handle11495215 Occurrence Handle10.1207/S15324796ABM2303_2 Occurrence Handle1:STN:280:DC%2BD3MvltVSgsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • KD Williams CKT Cheung W Choi (2000) ArticleTitleCyberostracism: effects of being ignored over the internet J Pers Soc Psychol 79 748–762 Occurrence Handle11079239 Occurrence Handle10.1037/0022-3514.79.5.748 Occurrence Handle1:STN:280:DC%2BD3M7islKktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • L Zadro KD Williams R Richardson (2004) ArticleTitleHow low can you go? Ostracism by a computer is sufficient to lower self-reported levels of belonging, control, self-esteem, and meaningful existence J Exp Soc Psychol 40 560–567 Occurrence Handle10.1016/j.jesp.2003.11.006

    Article  Google Scholar 

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Jarva, J., Oinonen, K. Do oral contraceptives act as mood stabilizers? Evidence of positive affect stabilization. Arch Womens Ment Health 10, 225–234 (2007). https://doi.org/10.1007/s00737-007-0197-5

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