Amino Acids

, Volume 32, Issue 2, pp 225–233

Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity

  • C. A. Hill
  • R. C. Harris
  • H. J. Kim
  • B. D. Harris
  • C. Sale
  • L. H. Boobis
  • C. K. Kim
  • J. A. Wise
Article

DOI: 10.1007/s00726-006-0364-4

Cite this article as:
Hill, C., Harris, R., Kim, H. et al. Amino Acids (2007) 32: 225. doi:10.1007/s00726-006-0364-4

Summary.

Muscle carnosine synthesis is limited by the availability of β-alanine. Thirteen male subjects were supplemented with β-alanine (CarnoSyn™) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine total work done (TWD) at 110% (CCT110%) of their maximum power (Wmax). Twelve matched subjects received a placebo. Eleven of these completed the CCT110% at 0 and 4 wks, and 8, 10 wks. Muscle biopsies were obtained from 5 of the 8 and one additional subject. Muscle carnosine was significantly increased by +58.8% and +80.1% after 4 and 10 wks β-alanine supplementation. Carnosine, initially 1.71 times higher in type IIa fibres, increased equally in both type I and IIa fibres. No increase was seen in control subjects. Taurine was unchanged by 10 wks of supplementation. 4 wks β-alanine supplementation resulted in a significant increase in TWD (+13.0%); with a further +3.2% increase at 10 wks. TWD was unchanged at 4 and 10 wks in the control subjects. The increase in TWD with supplementation followed the increase in muscle carnosine.

Keywords: β-alanine – Muscle – Carnosine – Taurine – Exercise – Cycle performance

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • C. A. Hill
    • 1
  • R. C. Harris
    • 1
  • H. J. Kim
    • 2
  • B. D. Harris
    • 1
  • C. Sale
    • 3
  • L. H. Boobis
    • 4
  • C. K. Kim
    • 2
  • J. A. Wise
    • 5
  1. 1.School of Sports, Exercise & Health Sciences, University of ChichesterChichesterU.K.
  2. 2.Human Exercise Physiology, Korea National Sport UniversitySeoulKorea
  3. 3.Centre for Human SciencesQinetiQU.K.
  4. 4.Sunderland Royal HospitalSunderlandU.K.
  5. 5.Natural Alternatives InternationalSan MarcosU.S.A.