Surgery Today

, Volume 44, Issue 4, pp 773–777

Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case

Authors

    • Division of Transplantation, Reconstruction and Endoscopic SurgeryTohoku University Hospital
  • Michio Watanabe
    • Division of Surgical OncologyTohoku University Hospital
  • Noriaki Nakashima
    • Division of Surgical OncologyTohoku University Hospital
  • Keisei Fujimori
    • Division of Surgical OncologyTohoku University Hospital
  • Kazuyuki Ishida
    • Division of PathologyTohoku University Hospital
  • Noriaki Ohuchi
    • Division of Surgical OncologyTohoku University Hospital
  • Hironobu Sasano
    • Division of PathologyTohoku University Hospital
Case Report

DOI: 10.1007/s00595-013-0568-7

Cite this article as:
Murakami, K., Watanabe, M., Nakashima, N. et al. Surg Today (2014) 44: 773. doi:10.1007/s00595-013-0568-7

Abstract

We report a case of water-clear cell adenoma associated with primary hyperparathyroidism. A 59-year-old woman with a history of renal stones and bone fracture was referred for investigation of hypercalcemia and an elevated serum parathyroid hormone level. Skeletal X-rays showed osteopenia and ultrasound showed enlarged tumors in both sides of the inferior thyroid region. Computed tomography demonstrated a tumor in the posterior aspect of the left thyroid lobe but no lesion in the right aspect of the neck. Grossly, we found a 500 mg left lower parathyroid gland (PTG) and a 100 mg right lower PTG. Histologically, the left lower PTG comprised mainly water-clear cells (WCCs) containing numerous vacuoles. Chief cells were dispersed among the WCCs, but the right lower PTG showed normal parathyroid tissue. Several investigators have speculated that WCCs are derived from chief cells, and we diagnosed WCC adenoma. Following this case report, we review the relevant literature.

Keywords

Water-clear cellAdenomaPrimary hyperparathyroidism

Copyright information

© Springer Japan 2013