Coexistence of papillary thyroid cancer with Hashimoto thyroiditis
Conflicting data have been reported with regard to Hashimoto thyroiditis (HT) and risk of malignancy. The aim of this study was to evaluate coexistence of papillary thyroid cancer (PTC) with HT.
Patients and methods
This is a retrospective cohort study in which HT was diagnosed in 452 (F/M ratio = 405:47, median age 53.5 ± 12.1 years) of 7,545 patients qualified for thyroidectomy throughout the years 2002 to 2010. Pathological reports were reviewed to identify prevalence of PTC in HT vs. non-HT patients.
PTC was diagnosed in 106 of 452 (23.5 %) HT patients vs. 530 of 7,093 (7.5 %) non-HT patients (p < 0.001). Metastases to level VI lymph nodes were observed in 81 of 106 (76.4 %) patients with PTC in HT vs. 121 of 530 (22.8 %) patients with PTC in non-HT disease (p < 0.001).
HT was associated with a threefold increase of PTC prevalence as compared to other non-HT thyroid diseases, and the spread of PTC to level VI lymph nodes was four times more frequent in HT than in non-HT patients.
- Coexistence of papillary thyroid cancer with Hashimoto thyroiditis
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Langenbeck's Archives of Surgery
Volume 398, Issue 3 , pp 389-394
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- Hashimoto thyroiditis
- Papillary thyroid carcinoma
- Benign thyroid disease
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- Author Affiliations
- 1. Department of Endocrine Surgery, 3rd Chair of General Surgery, Jagiellonian University Medical College, 37 Prądnicka Street, 31-202, Krakow, Poland
- 2. Department of Pathology, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531, Krakow, Poland