Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life
- First Online:
- Cite this article as:
- Jahanshahi, M., Torkamani, M., Beigi, M. et al. J Neurol (2014) 261: 164. doi:10.1007/s00415-013-7161-2
- 1k Downloads
We investigated the effect of pallidal deep brain stimulation (GPi-DBS) in dystonia on cognition, mood, and quality of life and also assessed if DYT1 gene status influenced cognitive outcome following GPi-DBS. Fourteen patients with primary generalized dystonia (PGD) were assessed, measuring their estimated premorbid and current IQ, memory for words and faces, and working memory, language, executive function, and sustained attention, one month before and one year or more after surgery. Changes in mood and behaviour and quality of life were also assessed. There was a significant improvement of dystonia with GPi-DBS (69 % improvement in Burke-Fahn-Marsden score, p < 0.0001). Performance on five cognitive tests either improved or declined at post-surgical follow-up. Calculation of a reliable change index suggested that deterioration in sustained attention on the PASAT was the only reliable change (worse after surgery) in cognition with GPi-DBS. DYT1 gene status did not influence cognitive outcome following GPi-DBS. Depression, anxiety and apathy were not significantly altered, and ratings of health status on the EQ5D remained unchanged. In our sample, GPi-DBS was only associated with an isolated deficit on a test of sustained attention, confirming that GPi-DBS in PGD is clinically effective and safe, without adverse effects on the main domains of cognitive function. The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients’ QoL, warrants further investigation.
KeywordsPrimary generalised dystoniaDeep brain stimulationGlobus pallidusCognitionExecutive function
Studies investigating cognition in primary dystonia using detailed neuropsychological assessment
Taylor et al. 
All idopathic dystonia with no cognitive impairment?
Wechsler memory scale
Tower of Toronto
Buschke selective reminding
Compared to age matched healthy controls; no differences found prior to medication.
However significant difference on explicit memory and reduced speed of information processing about 2–4 months after taking 15–74 mg of trihexyphenidyl daily
Jahanshahi et al. 
10 Idiopathic dystonia patients
3 generalized dystonia
5 Cervical dystonia
2 Focal arm dystonia
National adult reading test
Wisconsin card sorting test
Stroop colour word Naming test
Missing digit test
Self-ordered random number sequence test
Visual conditional associative learning
Conditional associative learning tests
Paced auditory serial addition test
Dual ask performance
random number generation
Only differences between the two groups was on category word fluency and dual task performance
Scott et al. 
14 patients with focal, segmental, or generalized dystonia
Cambridge neuropsychological test automated battery
Wisconsin card sorting test (set shifting)
National adult reading test
Raven’s standard progressive matrices
The symbol digit modalities test
The Stroop test
Trail making test
Categorical and phonemic verbal fluency
Speed of Comprehension from the speed and capacity of language processing test
Recognition memory test
Story recall subtest from the adult memory and information processing battery
Wechsler adults intelligence scale (digit span)
Medical College of Georgia Complex Figures
Boston naming test
Judgement of line orientation test
Only deficit on attentional set shifting on the Cambridge neuropsychological test automated batter. Significant difficulties negotiating the extra-dimensional set-shifting phase of the intra-extra dimensional set shift task.
Balas et al. 
28 DYT-1 gene carriers with childhood onset generalized dystonia:
20 symptomatic DYT1 dystonia- (SYM)
8 non- symptomatic DYT1 dystonia- (N-SYM)
Rey auditory verbal learning test
Rey complex figure
Language phonemic verbal fluency,
Semantic verbal fluency
Trail-making A and B
Cambridge neuropsychological test automated battery
Visual analog scale
Wechsler Adults Intelligence Scale
III (digit span and similarities)
Judgment of line orientation
Beck depression inventory
anxiety Spielberger state and trait anxiety questionnaire
No significant differences between the N-SYM group and the control group on any of the measures.
The only significant differences between the SYM group and controls were that the SYM group showed increased verbal memory retroactive interference
Allam et al. 
9 patients with primary carnial dystonia (blepharospasm)
Rey auditory verbal learning test
Wechsler memory scale-R-digit subtest
Wechsler intelligence scale-R-digit symbol subtest
Stroop colour word naming test
There were sustained attentional deficits prior to botox injections.
Following botox injections, there were no significant differences in sustained attention compared with controls
Bugalho et al. 
45 patients with primary dystonia (focal and segmental):
15 cervical dystonia
15 writer’s cramp
Wisconsin card sorting test
Benton’s visual retention test
Block assembly test from Wechsler adults intelligence scale
Yale brown obsessive compulsive scale
Patients made more preservative errors on Wisconsin Card sorting test and had a higher mean obsessive compulsive score than controls
Aleman et al. 
20 patients with primary carnial dystonia (blepharospasm)
Wechsler adults intelligence scale
Five digits test-Stroop
Oral making test
Wechsler memory scale
Compared to controls, matched for severity of depression and level of education, the patients showed impaired; complex movement planning, motor dexterity, visuospatial working memory, and tactile object recognition
Pallidal deep brain stimulation (GPi-DBS) is an established and effective treatment for dystonia [10, 11]. The safety of GPi-DBS for dystonia in relation to cognition has been shown in neuropsychological studies [12, 13] and clinical series following patients for up to three years postoperatively [10, 14], which conclude that GPi-DBS surgery does not affect post-operative cognition in primary dystonia.
The aim of this study was twofold: (1) to investigate the impact of bilateral GPi-DBS in PGD on cognitive function, mood and quality of life, (2) to examine if DYT1 gene status, which has been associated with better post-surgical outcome after GPi-DBS in PGD , influences cognition and mood following GPi-DBS.
Demographic and clinical details of the dystonia patients
Disease duration (years)
DYT 1 gene status
BFM score pre-op (0–120)
BFM score post-op (0–120)
R: 4,5-, 3.9v, 60:μs, 130 Hz
L: 0,1-, 3.9v, 60:μs, 130 Hz
R: 4,5-, 3.9 v, 90:μs, 130 Hz
L: 0,1-, 3.8 v, 90:μs, 130 Hz
R: 4-, 3.5v, 90:μs, 130 Hz
L: 0,1-, 3.3v, 60:μs, 130 Hz
R: 5-, 4.0v, 60:μs, 130 Hz
L: 1-, 4.2v, 60:μs, 130 Hz
R: 4-, 3.0v, 60:μs, 130 Hz
L: 0-, 3.0v, 60:μs, 130 Hz
R: 4-, 2.9v, 60:μs, 130 Hz
L: 0-, 2.9v, 60:μs, 130 Hz
R: 6-, 4.6v, 90:μs, 130 Hz
L: 2-, 4.6v, 90:μs, 130 Hz
R: 4-, 3.7v, 60:μs, 130 Hz
L: 1-, 3.7v, 60:μs, 130 Hz
R: 4-, 4.6v, 90:μs, 130 Hz
L: 0-, 4.2v, 90:μs, 130 Hz
R: 6-, 3.7v, 90:μs, 130 Hz
L: 1-, 3.7v, 90:μs, 130 Hz
R: 4-, 3.6v, 60:μs, 130 Hz
L: 0-, 3.6v, 60:μs, 130 Hz
R: 5,6-, 3.5v, 60:μs, 130 Hz
L: 1,2-, 3.5v, 60:μs, 130 Hz
R: 4,5-, 3.5v, 60:μs, 130 Hz
L: 1,2-, 3.5v, 60:μs, 130 Hz
R: 5-, 3.5v, 60:μs, 130 Hz
L: 1, 3.5v, 60:μs, 130 Hz
Patients were assessed prior to surgery, and one year or more post-operatively (mean duration of follow-up 14.4 ± 4.5 months).
The Mini Mental State Examination (MMSE)  for global cognitive functioning, the National Art Reading Test (NART)  for premorbid IQ and the Wechsler Adult Intelligence Test-Revised (WAIS-R)  for current verbal IQ were used. The Auditory Verbal Learning Test (RAVLT) , the recognition memory for faces-short form (RMF)  , and the Self-Ordered Pointing Test  were respectively used to assess episodic memory for words, memory for non-verbal material and working memory. The phonemic, semantic and alternating versions of the Verbal Fluency Test  and the Graded Naming Test  were employed for language assessment. Tests of executive function included the Modified Wisconsin Card Sorting Test (MWCST)  for maintaining and shifting ‘set’, the Stroop colour word naming task  to measure inhibition of proponent/habitual responses, and the Trial Making Test  for behavioural regulation and task switching. The Paced Auditory Serial Addition Test (PASAT)  was used to assess sustained attention.
The Beck Depression Inventory (BDI) , Beck Anxiety Inventory (BAI) , and the Apathy Evaluation Scale (AES)  were used to measure depression, anxiety and apathy, respectively. Higher scores on these measures are indicative of high depression, anxiety and apathy. The EQ5D , which covers five quality of life (QoL) dimensions (mobility, self-care, usual activities, pain/discomfort and anxiety/depression), was used to measure QoL. The EQ5D includes a visual analogue scale (VAS) used for rating ‘current health state’ with a range of 0(worst imaginable health)–100(best imaginable health), and the five subscores of the test can be combined to give a summary index value of 0–1, with lower scores representing poorer overall QoL.
The study was approved by the Joint Research Committee of the National Hospital for Neurology and Neurosurgery and the Institute of Neurology, London, UK. All patients gave written informed consent.
Pre vs. post-operative change in dystonia
Mean BFM score was 39.9 (SD = 17.4) at baseline and 13.3 (SD = 11.6) after surgery. Dystonia was significantly improved from before to after surgery[t(13) = 7.6, p < 0.0001]. The average improvement in dystonia was 68.7 % (±20.8).
Pre vs. post-operative change in cognitive function
Mean and standard deviations (SD) of the pre-surgical and post-surgical scores for the dystonia patients on the measures of cognitive function
Pre-surgery mean (SD)
Post-surgery mean (SD)
Mini mental state examination (max = 30)
Verbal IQ (prorated)
Correct recall: Trial 1 (max 15)
Correct recall: Trial 5 (max 15)
Recognition: total correct (max 15)
Recognition: false positives
Short recognition memory for faces
Total correct (max 25)
4 items (mean errors)
8 items (mean errors)
12 items (mean errors)
Verbal fluency total words generated
Category switching fluency
Graded naming test
Total correct (max 30)
Modified Wisconsin card sorting
Categories correctly sorted (max = 6)
Control colour naming time(ms)
Control colour naming number of errors
Stroop interference time(ms)
Stroop interference numbers of errors
Difference score in completion time (ms)
Trails A and B
Trails A: completion time (ms)
Trails B: completion time (ms)
Difference Trail B−A (ms)
Total errors (max 30)
Reliable change indices for the three cognitive measures showing post-operative decline in performance
% No change
95 % RCI criterion
Words recalled on Trial 5
Pre-operative vs. post-operative change in mood
Self-ratings of depression, anxiety, apathy, effort, physical and mental fatigue, and quality of life by the patients with dystonia before and after surgery
Beck Depression Inventory (0–63)
Beck Anxiety Inventory (0–63)
AES-total apathy score (18–72)
AES: emotional subtest (2–8)
AES: cognitive subtest (8–32)
AES: behavioural subtest (5–20)
AES: other items (3–12)
Physical fatigue (0–10)
Mental fatigue (0–10)
EQ5D summary index
EQ5D health statue (VAS)
Pre-operative vs. post-operative change in quality of life
There was no significant difference between assessments in the EQ5D summary index [t(10) = 1.589, p = 0.141] or VAS[t(10) = -0.101, p = 0.921]. However, the percentage of patients experiencing problems was reduced post-surgery compared to baseline in all EQ5D domains except anxiety/depression, although these differences were not significantly different (see Table 5). Correlation analyses showed no statistical correlation between change in dystonia and change in QoL from before to after surgery (EQ5D summary index: r = −0.618, p = 0.057; EQ5D vas, r = −0.115, p = 0.751).
DYT1 gene status and cognitive outcome with GPi-DBS
A series of two-way ANOVAs with Group (DYT1 positive, vs. negative) as the between-groups variable and time of assessment (pre-surgery vs. post-surgery) as the within-subject variable were completed. The results revealed only a main effect of time for WAIS-R digit span [F(1,10) = 6.66, p < 0.05], RAVLT (Trial 5) [F(1,12) = 6.25, p < 0.05] and PASAT [F(1,7) = 8.84, p < 0.05] (see Table 3), but no significant interactions. Therefore, the DYT1 gene status did not influence cognitive outcome following GPi-DBS.
Correlation of demographic and clinical features with change in cognitive scores with GPi-DBS
We examined the association of clinical and demographic features and change in cognitive measures using Pearson correlation coefficients. Duration of illness correlated with changes in trail making (version B) [r(14) = −0.58, p < 0.03] and trail making difference score (version B−A) [r(14) = −0.60, p < 0.02]. Age of onset correlated with changes in trail making (version B) [r(14) = 0.55, p < 0.04]. The BMF pre-operative scores correlated with changes in WAIS-R (verbal IQ) [r(14) = 0.61, p < 0.02], category fluency [r(13) = 0.615, p < 0.03] and switching [r(13) = 0.57, p < 0.05].
The pulse width of the right contact correlated with change in WAIS similarities [r(14) = 0.55, p < 0.04]. The amplitude of DBS on the right and left contact correlated with changes in RAVLT (Trial 5) [r(14) = 0.68, p < 0.01 and r(14) = 0.59, p < 0.03, respectively]. There were no other significant correlations, including between the stimulation parameters and change in PASAT scores (all p > 0.05). Furthermore, we did not find a significant difference in PASAT change scores between patients with high (90 μs) versus low (60 μs) pulse width (p > 0.05). Similarly with a median split on the DBS amplitudes, patients with high versus low stimulation amplitudes did not show any significant differences in PASAT change scores (p > 0.05).
The results of this study confirmed the benefits of GPi-DBS for PGD, showing a significant post-surgical improvement. GPi-DBS did not affect IQ, memory, language and executive function. The only reliable change following surgery was worse performance on PASAT. DYT1 gene status did not influence post-surgical cognitive outcome. There were no significant changes in depression, anxiety or apathy after surgery. Despite fewer patients experiencing problems in four of the EQ5D domains after surgery, the differences were not significant.
In line with previous literature, our results show no change in most aspects of cognition following GPi-DBS or subthalamic(STN)-DBS, and show variability in cognitive outcomes, with findings of deterioration, improvement, and no change [10, 14, 35]. In a case series, Kleiner-Fisman et al.  reported a mild but non-significant decline in executive function, and significantly worse verbal and visual memory after STN-DBS. Similarly, Kiss  reported significant decline in verbal fluency in one case and in verbal memory in another but without any impact on the patient’s daily life. In our study, RCI calculations showed that after GPi-DBS only the deterioration in the PASAT was clinically significant; whereas deterioration in digit span and RAVLT(Trial 5), and improvement on MWCST and stroop (control task) were not reliable.
Close inspection of the PASAT data showed that in all but one participant, error scores had increased at follow-up. PASAT requires participants to hold the last number presented ‘on line’ in working memory, add it to the next number, and provide their sum. Errors are often linked to failure to respond, due to the inability to maintain attention/information in working memory, and/or to manipulate the information to generate a response. GPi-DBS could have interfered with any of these processes, resulting in poorer performance. The change in PASAT scores did not have any significant associations with the DBS parameters. The point of entry of the electrodes is likely to be through the supplementary motor area (SMA, BA 6). However, any ‘insult’ to frontal areas during electrode entry is minimal, and it is likely that any effects relate to chronic stimulation of the motor front-striatal circuit. In the motor circuit there are separate projections from the GPi to the motor cortex, SMA and the lateral part of Brodmann area six, the lateral premotor cortex . Furthermore, the SMA and the lateral premotor cortex are hyperactive in primary dystonia . The SMA and the lateral premotor cortex are among the areas activated during performance of the PASAT , and have been shown in animal experimentation to be involved in response selection on the basis of internal versus external cues , processes that are involved in the PASAT in addition to working memory. It is thus possible that the impaired performance on the PASAT following GPi DBS in the present sample relates to the effects of GPi stimulation on these medial and lateral premotor areas. This proposal needs to be tested in future studies.
Some studies have reported improvements in performance on tests of cognitive function after GPi-DBS for children with secondary dystonia  and adults with dystonia . Pillon et al.  reported mild but significant improvement in performance on Raven progressive matrices, WAIS-R (similarities), MWCST (non-perservative errors) and free verbal recall, which were all maintained at three years follow-up . Halbig et al.  also found a significant post-surgical improvement on the trail making test (version A) after surgery. However, the pre-operative assessment of cognition may have been affected by the severity of dystonia and thus the post-operative improvement may partly reflect the symptomatic improvement. Where the interval between baseline and follow-up have been short, practice effects may have influenced performance. Also, the effects of anti-cholinergic medication used for the treatment of dystonia on cognition and changes of this medication following GPi-DBS needs to be considered. In this sample, there were no changes in medication between baseline and the post-surgical assessment. To avoid the confounding effects of medication changes on the time course of clinical improvement in dystonia after GPi-DBS, no changes were made in medication for the first 12 months, so the 12 month post-op medications remained the same as baseline. However after 30 months, four of the six patients on Artane were able to reduce their dose by a mean of 36–11 mg, and four others stopped or reduced sulpiride, l-Dopa, baclofen, and/or diazepam by 24 months.
Patients positive for the DYT1 gene are shown to benefit more from GPi-DBS in some  but not all studies [10, 11]. Our results show that DYT1 gene status did not influence change in cognition with GPi-DBS. However, correlational analyses suggest association between key clinical variables and cognitive change following GPi-DBS. A shorter duration of illness, older age of onset and more severe dystonia prior to surgery were associated with greater change in executive function and verbal IQ with GPi-DBS. Higher amplitude and pulse width of GPi-DBS were associated with greater change in concept formation and verbal memory.
Despite significant improvement of dystonia, depression and anxiety remained unchanged in our sample. The lack of significant change in mood following GPi-DBS may reflect the mild anxiety and absence of depression at baseline. The majority of previous studies excluded cases with major psychiatric illness from surgery . While some have found that mild-moderate depression improves after GPi-DBS in dystonia [12, 14]; others have not [10, 11]. Generally, anxiety scores do not change with GPi-DBS. These suggest that depression and anxiety can remain unchanged following successful GPi-DBS in dystonia, as found in the current study. Suicide has been documented in association with DBS in dystonia. Foncke et al.  reported that two of their 16 participants treated with GPi-DBS committed suicide. Suicide is preventable, and regular monitoring of operated patients, including direct enquiry about suicidal ideations is highly recommended .
QoL is impaired in dystonia and a greater percent of dystonia patients report problems on all EQ5D domains compared to the general population . After GPi-DBS, a lower percent of patients in this study reported problems on all EQ5D items except depression/anxiety. However, the summary index and VAS were not significantly altered by surgery, and correlation analysis revealed no significance between improvement in dystonia and change in QoL. Although some studies report post-surgical improvement in most QoL domains in dystonia , others suggest that surgery primarily improves the physical domains and to a lesser extent the emotional components of QoL . Given that surgery aims to improve QoL, a lack of positive impact of improvement in dystonia on QoL is at first sight puzzling and of clinical concern. Why doesn’t the significant improvement of dystonia translate into significant improvement of QoL? One possibility is that generic measures may not be sensitive in picking up changes unique to PGD. The EQ5D measures mainly the physical parameters of health, and the lack of improvement in QoL may reflect the simplicity of the measure. Alternatively, our current assessment techniques may not be targeting key patient concerns, highlighting the need to also assess their expectations. Also, while GPi-DBS produces relatively rapid improvement of dystonia, psychosocial adjustment to the functional improvements may require longer time. We have some evidence for this from interviews with operated patients , who expressed a need to adapt to their ‘new and improved’ body. This was eloquently expressed by one patient “Now, even though I have been given a new body, I haven’t been given a new mind. It’s like plastic surgery, you might change your nose but how you feel about yourself is still the same”. Such dissociation between the physical change and psychological adjustment may be quantifiable with longitudinal assessments of changes in dystonia symptoms, mood and QoL, thus warranting further investigation.
In conclusion, our results confirm that GPi-DBS is an effective treatment for PGD without producing any major adverse impact on cognition, other than isolated deterioration of performance on a test of sustained attention. Despite significant improvement of dystonia with GPi-DBS, surgery did not significantly alter depression, anxiety, apathy or QoL. This dissociation between GPi-DBS improving dystonia but not having a significant positive impact on the patients’ QoL warrants further investigation.
The research was supported by an NIH R01 grant (NS40865-02, PI: MJ).
Conflicts of interest
There are no conflicts of interest. MT and LM were supported by a European Commission, Ambient Assisted Living grant. MB was supported by a 3 + 1 MRC/ESRC PhD studentship. LW was supported by a Career Development Fellowship, Parkinson’s UK. DP was supported by a R01 grant from the National Institutes of Neurological Disorders and Stroke, NIH (Number NS40862-02, PI MJ). DR was funded by the Dorothy Feiss Scientific Research Grant, Bachmann-Strauss Foundation and the Tourette Syndrome Association (TSA), USA. MH, PL, LZ are supported by the Parkinson’s Appeal and the Monument Trust.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.