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Adult-onset Alexander disease with an R66Q mutation in GFAP presented with severe vocal cord paralysis during sleep

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Acknowledgments

We thank Crimson Interactive Pvt. Ltd. for English editing and proofreading.

Conflicts of interest

None.

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Author notes

  1. Ayumi Hida

    Present address: Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

Authors and Affiliations

  1. Department of Neurology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan

    Ayumi Hida, Noritoshi Arai, Yoshikazu Uesaka & Sousuke Takeuchi

  2. Department of Otorhinolaryngology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan

    Hisayo Fukuoka

  3. Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan

    Kanehiro Hasuo

  4. Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Hiroyuki Ishiura, Jun Goto & Shoji Tsuji

Authors
  1. Ayumi Hida
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  2. Hiroyuki Ishiura
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Corresponding author

Correspondence to Ayumi Hida.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Awake-laryngofiberscopy showed mild abduction restriction during inspiration and glottic stenosis during expiration. (MP4 3717 kb)

After intravenous diazepam (5 mg) administration, the bilateral vocal cords were almost fixed in the paramedian position, and only a 1-mm hole remained during inspiration. (MP4 4344 kb)

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Hida, A., Ishiura, H., Arai, N. et al. Adult-onset Alexander disease with an R66Q mutation in GFAP presented with severe vocal cord paralysis during sleep. J Neurol 259, 2234–2236 (2012). https://doi.org/10.1007/s00415-012-6540-4

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  • DOI: https://doi.org/10.1007/s00415-012-6540-4

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