Journal of Neurology

, Volume 259, Issue 10, pp 2234–2236

Adult-onset Alexander disease with an R66Q mutation in GFAP presented with severe vocal cord paralysis during sleep

  • Ayumi Hida
  • Hiroyuki Ishiura
  • Noritoshi Arai
  • Hisayo Fukuoka
  • Kanehiro Hasuo
  • Jun Goto
  • Yoshikazu Uesaka
  • Shoji Tsuji
  • Sousuke Takeuchi
Letter to the Editors

DOI: 10.1007/s00415-012-6540-4

Cite this article as:
Hida, A., Ishiura, H., Arai, N. et al. J Neurol (2012) 259: 2234. doi:10.1007/s00415-012-6540-4

Supplementary material

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Awake-laryngofiberscopy showed mild abduction restriction during inspiration and glottic stenosis during expiration. (MP4 3717 kb)

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After intravenous diazepam (5 mg) administration, the bilateral vocal cords were almost fixed in the paramedian position, and only a 1-mm hole remained during inspiration. (MP4 4344 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Ayumi Hida
    • 1
    • 5
  • Hiroyuki Ishiura
    • 4
  • Noritoshi Arai
    • 1
  • Hisayo Fukuoka
    • 2
  • Kanehiro Hasuo
    • 3
  • Jun Goto
    • 4
  • Yoshikazu Uesaka
    • 1
  • Shoji Tsuji
    • 4
  • Sousuke Takeuchi
    • 1
  1. 1.Department of NeurologyNational Center for Global Health and MedicineTokyoJapan
  2. 2.Department of OtorhinolaryngologyNational Center for Global Health and MedicineTokyoJapan
  3. 3.Department of RadiologyNational Center for Global Health and MedicineTokyoJapan
  4. 4.Department of Neurology, Graduate School of MedicineUniversity of TokyoBunkyo-kuJapan
  5. 5.Department of Neurology, Graduate School of MedicineUniversity of TokyoBunkyo-kuJapan