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Polysomnographic Differences Associated with Pulmonary Hypertension in Patients with Advanced Lung Disease Due to Cystic Fibrosis

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Abstract

Background

Pulmonary hypertension (PH) commonly occurs in patients with cystic fibrosis (CF), but there is no current data regarding alterations of sleep in patients with PH.

Methods

A single-center, retrospective review was performed in patients with advanced lung disease due to CF who completed both nocturnal polysomnography and right heart catheterization (RHC) from January 2010 to June 2013. For statistical analysis, two-tailed unpaired t tests and Pearson correlation coefficient analysis were performed after normal distribution was confirmed.

Results

A total of 18 consecutive CF patients were enrolled with RHC identifying PH in 56 % (10/18) of patients. The PH group had significantly lower mean sleep efficiency (72 ± 4 vs. 87 ± 3 %, p = 0.01), significantly higher ETCO2 levels (54.5 ± 2.2 vs. 43.8 ± 3.0 mmHg, p = 0.01) on capnography, and significantly lower PO2 (53.8 ± 3.1 vs. 65.5 ± 3.9 mmHg, p = 0.03) on capillary blood gas. Correlations with poor sleep efficiency included mean PAP (r = − 0.55, p = 0.01), systolic PAP (r = −0.5, p = 0.03), ETCO2 (r = − 0.53, p = 0.02), and PO2 (r = 0.62, p = 0.01); ETCO2 with systolic PAP (r = 0.47, p = 0.04) and PCO2 (r = − 0.57, p = 0.01); and PO2 to 6-min walk distance (r = 0.55, p = 0.02).

Conclusions

We found significant differences in sleep efficiency and gas exchange associated with PH in CF patients with advanced lung disease.

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Conflict of interest

The authors report no conflicts of interest and have no relevant financial disclosures.

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Authors and Affiliations

  1. Department of Pediatrics, The Ohio State University, Columbus, OH, USA

    Don Hayes Jr., Curt J. Daniels, Stephen Kirkby, Benjamin T. Kopp & Mark L. Splaingard

  2. Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

    Don Hayes Jr., Curt J. Daniels & Stephen Kirkby

  3. Section of Pulmonary Medicine, Nationwide Children’s Hospital, Columbus, OH, USA

    Don Hayes Jr., Stephen Kirkby, Benjamin T. Kopp, Kerri L. Nicholson, Ashley E. Nance & Mark L. Splaingard

  4. Section of Cardiology, Nationwide Children’s Hospital, Columbus, OH, USA

    Curt J. Daniels

  5. The Ohio State University, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH, 43205, USA

    Don Hayes Jr.

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  1. Don Hayes Jr.
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Correspondence to Don Hayes Jr..

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Hayes, D., Daniels, C.J., Kirkby, S. et al. Polysomnographic Differences Associated with Pulmonary Hypertension in Patients with Advanced Lung Disease Due to Cystic Fibrosis. Lung 192, 413–419 (2014). https://doi.org/10.1007/s00408-014-9573-x

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