, Volume 191, Issue 5, pp 445-447
Date: 28 Jul 2013

Identification of the Nodose Ganglia and TRPV1 in Swine

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The vagal nerve is the tenth cranial nerve (CN) and is the only CN to extend through the neck into the thorax and abdomen. As a component of the autonomic nervous system, the vagal nerve innervates the visceral organs, including the lung. The majority of the bronchopulmonary sensory nerves are unmyelinated (C-fiber) afferents of the vagal nerve. The cell bodies of the visceral afferent fibers of the vagus nerve are located bilaterally in the inferior ganglion—also termed the nodose ganglia (NG). More recently, transient receptor potential vanilloid type 1 (TRPV1) channels have been identified and are expressed on the vagal C-fiber afferents, which play an important role in the cholinergic reflex pathway [13]. TRPV1 channels are nonselective cation channels and polymodal transducers that are known to be activated by increasing temperature, acidity (hydrogen ion), and endogenous inflammatory mediators [13].

Although differences exist between swine and human anatomy, the patterns of the

The study was approved by the Institutional Animal Care and Use Committee (IACUC) of the Nationwide Children’s Hospital with strict adherence to the IACUC guidelines regarding humane use of animals.
The work and subsequent manuscript was completed at the Nationwide Children’s Hospital and The Ohio State University, Columbus, OH.