Skip to main content

Advertisement

Log in

Medical prevention and treatment of postpartum hemorrhage: a comparison of different guidelines

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Postpartum hemorrhage (PPH) remains a common cause of maternal mortality worldwide, mainly caused by uterine atony. Medical intervention plays an important part in prevention and therapies of PPH. Prophylactic interventions include the use of uterotonic drugs. We elaborated the consistency of national and international guidelines on those medical approaches.

Materials and methods

Medical approaches in PPH were extracted from recent publications. Furthermore, the current guidelines of the World Health Organization, the FIGO and of the American, British, Canadian and German Societies of Obstetricians and Gynecologists on PPH were analyzed.

Results

Oxytocin is considered as therapy of first choice. However, the examined guidelines fail to give unequivocal recommendations on further uterotonics in PPH, which may partially be attributed to differing publication dates of the guidelines.

Conclusion

International guidelines on PPH are characterized by differing recommendations. However, recent publications suggest that adhering to local guidelines significantly reduces the prevalence of severe PPH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

ACOG:

American Congress of Obstetricians and Gynecologists

DGGG:

German Society for Gynecology and Obstetrics

FIGO:

Fédération Internationale de Gynécologie et d’ Obstétrique

PPH:

Postpartum hemorrhage

RCOG:

Royal College of Obstetricians and Gynaecologists

SOGC:

Society of Obstetricians and Gynaecologists of Canada

WHO:

World Health Organization

References

  1. Abou Zahr C (2003) Global burden of maternal death and disability. Br Med Bull 67:1–11

    Article  Google Scholar 

  2. ACOG Practice Bulletin (2006) Clinical management guidelines for obstetricians and gynecologists: postpartum hemorrhage. Number 76. Obstet Gynecol 108:1039–1047

    Article  Google Scholar 

  3. Aeby A, Johansson AB, De Schuiteneer B, Blum D (2003) Methylergometrine poisoning in children: review of 34 cases. J Toxicol Clin Toxicol 41:249–253

    Article  CAS  PubMed  Google Scholar 

  4. Aflaifel N, Weeks AD (2012) Active management of the third stage of labour. BMJ 345:e4546

    Article  PubMed  Google Scholar 

  5. Askar AA, Ismail MT, El-Ezz AA, Rabie NH (2011) Carbetocin versus syntometrine in the management of third stage of labor following vaginal delivery. Arch Gynecol Obstet 284:1359–1365

    Article  CAS  PubMed  Google Scholar 

  6. Badejoko OO, Ijarotimi AO, Awowole IO, Loto OM, Badejoko BO, Olaiya DS et al (2012) Adjunctive rectal misoprostol versus oxytocin infusion for prevention of postpartum hemorrhage in women at risk: a randomized controlled trial. J Obstet Gynaecol Res 38:1294–1301

    Article  PubMed  Google Scholar 

  7. Begley CM, Gyte GM, Devane D, McGuire W, Weeks A (2011) Active versus expectant management for women in the third stage of labour. Cochrane Database Syst Rev 11:CD007412

    PubMed  Google Scholar 

  8. Bellad MB, Tara D, Ganachari MS, Mallapur MD, Goudar SS, Kodkany BS, Sloan NL, Derman R (2012) Prevention of postpartum haemorrhage with sublingual misoprostol or oxytocin: a double-blind randomised controlled trial. BJOG 119:975–982

    Article  CAS  PubMed  Google Scholar 

  9. Biswas A, Roy S (1996) A comparative study of the efficacy and safety of synthetic prostaglandin E2 derivative and 15-methyl prostaglandin F2 alpha in the termination of midtrimester pregnancy. J Indian Med Assoc 94:292–293

    CAS  PubMed  Google Scholar 

  10. Bolton TJ, Randall K, Yentis SM (2003) Effect of the confidential enquiries into maternal deaths on the use of Syntocinon® of caesarean section in the UK. Anaesthesia 58:277–279

    Article  CAS  PubMed  Google Scholar 

  11. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B (2010) Minimum effective bolus dose of oxytocin during elective Caesarean delivery. Br J Anaesth 104:338–343

    Article  CAS  PubMed  Google Scholar 

  12. Carroli G, Cuesta C, Abalos E, Gülmezoglu AM (2008) Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol 22:999–1012

    Article  PubMed  Google Scholar 

  13. Carvalho JC, Balki M, Kingdom J, Windrim R (2004) Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol 104:1005–1010

    Article  CAS  PubMed  Google Scholar 

  14. Cordovani D, Balki M, Farine D, Seaward G, Carvalho JC (2012) Carbetocin at elective Cesarean delivery: a randomized controlled trial to determine the effective dose. Can J Anaesth 59:751–757

    Article  PubMed  Google Scholar 

  15. Douglas MJ, Farquharson DF, Ross PL, Renwick JE (1989) Cardiovascular collapse following an overdose of prostaglandin F2 alpha: a case report. Can J Anaesth 36:466–469

    Article  CAS  PubMed  Google Scholar 

  16. Driessen M, Bouvier-Colle MH, Dupont C, Khoshnood B, Rudigoz RC, Deneux-Tharaux C (2011) Postpartum hemorrhage resulting from uterine atony after vaginal delivery: factors associated with severity. Obstet Gynecol 117:21–31

    Article  PubMed  PubMed Central  Google Scholar 

  17. Dupont C, Touzet S, Colin C, Deneux-Tharaux C, Rabilloud M, Clement HJ et al (2009) Incidence and management of postpartum haemorrhage following the dissemination of guidelines in a network of 16 maternity units in France. Int J Obstet Anesth 18:320–327

    Article  CAS  PubMed  Google Scholar 

  18. Dupont C, Deneux-Tharaux C, Touzet S, Colin C, Bouvier-Colle MH, Lansac J, Thevenet S, Boberie-Moyrand C, Piccin G, Fernandez MP, Rudigoz RC (2011) Clinical audit: a useful tool for reducing severe postpartum haemorrhages? Int J Qual Health Care 23:583–589

    Article  PubMed  PubMed Central  Google Scholar 

  19. Dyer RA, Butwick AJ, Carvalho B (2011) Oxytocin for labour and caesarean delivery: implications for the anaesthesiologist. Curr Opin Anaesthesiol 24:255–261

    Article  PubMed  Google Scholar 

  20. Erkkola R, Kanto J, Allonen H, Kleimola T, Mäntylä R (1978) Excretion of methylergometrine (methylergonovine) into the human breast milk. Int J Clin Pharmacol Biopharm 16:579–580

    CAS  PubMed  Google Scholar 

  21. Gazvani MR, Luckas MJ, Drakeley AJ, Emery SJ, Alfirevic Z, Walkinshaw SA (1998) Intraumbilical oxytocin for the management of retained placenta: a randomized controlled trial. Obstet Gynecol 91:203–207

    Article  CAS  PubMed  Google Scholar 

  22. Ge J, Liao H, Duan L, Wei Q, Zeng W (2012) Uterine packing during cesarean section in the management of intractable hemorrhage in central placenta previa. Arch Gynecol Obstet 285:285–289

    Article  PubMed  Google Scholar 

  23. German Society for Gynecology and Obstetrics (DGGG). Diagnosis and therapy of postpartum hemorrhage. Guidelines 2010 http://www.dggg.de/fileadmin/public_docs/Leitlinien/3-3-5-peripartale-blutungen-2010.pdf

  24. Ghai B, Vayjnath AM, Lal S (2006) Acute pulmonary oedema following oxytocin administration: a life threatening complication. J Indian Med Assoc 104:261–262

    PubMed  Google Scholar 

  25. Grönvall M, Tikkanen M, Tallberg E, Paavonen J, Stefanovic V. Use of Bakri balloon tamponade in the treatment of postpartum hemorrhage: a series of 50 cases from a tertiary teaching hospital. Acta Obstet Gynecol Scand. 2012 Aug 22. (Epub ahead of print)

  26. Gülmezoglu AM, Forna F, Villar J, Hofmeyr GJ (2007) Prostaglandins for preventing postpartum haemorrhage. Cochrane Database Syst Rev 3:CD000494

    PubMed  Google Scholar 

  27. Gülmezoglu AM, Lumbiganon P, Landoulsi S, Widmer M, Abdel-Aleem H, Festin M, Carroli G, Qureshi Z, Souza JP, Bergel E, Piaggio G, Goudar SS, Yeh J, Armbruster D, Singata M, Pelaez-Crisologo C, Althabe F, Sekweyama P, Hofmeyr J, Stanton ME, Derman R, Elbourne D (2012) Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial. Lancet 379:1721–1727

    Article  PubMed  Google Scholar 

  28. Güngördük K, Asicioglu O, Besimoglu B, Güngördük OC, Yildirm G, Ark C et al (2010) Using intraumbilical vein injection of oxytocin in routine practice with active management of the third stage of labor: a randomized controlled trial. Obstet Gynecol 116:619–624

    Article  PubMed  Google Scholar 

  29. Habek D, Franicević D (2007) Intraumbilical injection of uterotonics for retained placenta. Int J Gynaecol Obstet 99:105–109

    Article  CAS  PubMed  Google Scholar 

  30. Harara R, Hanafy S, Zidan MS, Alberry M (2011) Intraumbilical injection of three different uterotonics in the management of retained placenta. J Obstet Gynaecol Res 37:1203–1207

    Article  CAS  PubMed  Google Scholar 

  31. Hayashi RH, Castillo MS, Noah ML (1984) Management of severe postpartum hemorrhage with a prostaglandin F2 alpha analogue. Obstet Gynecol 63:806–808

    CAS  PubMed  Google Scholar 

  32. Higgins L, Mechery J, Tomlinson AJ (2011) Does carbetocin for prevention of postpartum haemorrhage at caesarean section provide clinical or financial benefit compared with oxytocin? J Obstet Gynaecol 31:732–739

    Article  CAS  PubMed  Google Scholar 

  33. Hogerzeil HV, Walker GJ (1996) Instability of (methyl)ergometrine in tropical climates: an overview. Eur J Obstet Gynecol Reprod Biol 69:25–29

    Article  CAS  PubMed  Google Scholar 

  34. Ishibashi T, Ishibashi S, Uchida T, Nakazawa K, Makita K (2011) Reversible cerebral vasoconstriction syndrome with limb myoclonus following intravenous administration of methylergometrine. J Anesth 25:405–408

    Article  PubMed  Google Scholar 

  35. Jacobs AJ (2012) Management of postpartum hemorrhage at vaginal delivery. http://www.uptodate.com

  36. Jacobs MM, Arias F (1980) Intramyometrial prostaglandin F2 alpha in the treatment of severe postpartum hemorrhage. Obstet Gynecol 55:665–666

    CAS  PubMed  Google Scholar 

  37. Jonsson M, Hanson U, Lidell C, Nordén-Lindeberg S (2010) ST depression at caesarean section and the relation to oxytocin dose. A randomised controlled trial. BJOG 117:76–83

    Article  CAS  PubMed  Google Scholar 

  38. Kerekes L, Domokos N (1979) The effect of prostaglandin F2 alpha on third stage labor. Prostaglandins 18:161–166

    Article  CAS  PubMed  Google Scholar 

  39. Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF (2006) WHO analysis of causes of maternal death: a systematic review. Lancet 367:1066–1074

    Article  PubMed  Google Scholar 

  40. Khan MM, Gupta S, Radford P, Male DA (2002) Dose of oxytocin after caesarean section. Anaesthesia 57:723–724

    Article  CAS  PubMed  Google Scholar 

  41. Knight M, Callaghan WM, Berg C, Alexander S, Bouvier-Colle MH, Ford JB et al (2009) Trends in postpartum hemorrhage in high resource countries: a review and recommendations from the International Postpartum Hemorrhage Collaborative Group. BMC Pregnancy Childbirth 9:55–65

    Article  PubMed  PubMed Central  Google Scholar 

  42. Krumnikl JJ, Böttiger BW, Strittmatter HJ, Motsch J (2002) Complete recovery after 2 h of cardiopulmonary resuscitation following high-dose prostaglandin treatment for atonic uterine haemorrhage. Acta Anaesthesiol Scand 46:1168–1170

    Article  CAS  PubMed  Google Scholar 

  43. Langer B, Boudier E, Haberstich R, Dreyfus M (2004) Obstetrical management in the event of persistent or worsening postpartum hemorrhage despite initial measures. J Gynecol Obstet Biol Reprod (Paris) 33(8 Suppl): 4S73–4S79

    Google Scholar 

  44. Leduc D, Senikas V, Lalonde AB (2010) Active management of the third stage of labour: prevention and treatment of post partum hemorrhage (SOGC Clinical Practice Guidelines NO. 235). Int J Gynecol Obstet 108:258–267

    Google Scholar 

  45. Liabsuetrakul T, Choobun T, Peeyananjarassri K, Islam QM (2007) Prophylactic use of ergot alkaloids in the third stage of labour. Cochrane Database Syst Rev 2: CD005456

  46. Maier RC (1993) Control of postpartum hemorrhage with uterine packing. Am J Obstet Gynecol 169:317–321

    Article  CAS  PubMed  Google Scholar 

  47. Makkonen M, Suonio S, Saarikoski S (1995) Intraumbilical oxytocin for management of retained placenta. Int J Gynaecol Obstet 48:169–172

    Article  CAS  PubMed  Google Scholar 

  48. Meinen K, Lange R, Breinl H (1988) Intramyometrial PGF2 alpha administration in the control of severe atonic postpartum hemorrhage. Geburtshilfe Frauenheilkd 48:268–270

    Article  CAS  PubMed  Google Scholar 

  49. McDonald S, Prendiville WJ, Elbourne D (2004) Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour. Cochrane Database Syst Rev 1:CD000201

    PubMed  Google Scholar 

  50. Moertl MG, Friedrich S, Kraschl J, Wadsack C, Lang U, Schlembach D (2011) Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial. BJOG 118:1349–1356

    Article  CAS  PubMed  Google Scholar 

  51. Mori R, Nardin JM, Yamamoto N, Carroli G, Weeks A (2012) Umbilical vein injection for the routine management of third stage of labour. Cochrane Database Syst Rev 3:CD006176

    PubMed  Google Scholar 

  52. Mousa HA, Walkinshaw S (2001) Major postpartum haemorrhage. Curr Opin Obstet Gynecol 13:595–603

    Article  CAS  PubMed  Google Scholar 

  53. Mousa HA, Alfirevic Z (2007) Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev 1:CD003249

    PubMed  Google Scholar 

  54. Munn MB, Owen J, Vincent R, Wakefield M, Chestnut DH, Hauth JC (2001) Comparison of two oxytocin regimens to prevent uterine atony at cesarean delivery: a randomized controlled trial. Obstet Gynecol 98:386–390

    Article  CAS  PubMed  Google Scholar 

  55. Nardin JM, Weeks A, Carroli G (2011) Umbilical vein injection for management of retained placenta. Cochrane Database Syst Rev 5:CD001337

    PubMed  Google Scholar 

  56. Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL (2010) How to improve R&D productivity: the pharmaceutical industry’s grand challenge. Nat Rev Drug Discov 9:203–214

    CAS  PubMed  Google Scholar 

  57. Pinder AJ, Dresner M, Calow C, Shorten GD, O’Riordan J, Johnson R (2002) Haemodynamic changes caused by Oxytocin during caesarean section under spinal anaesthesia. Int J Obstet Anesth 11:156–159

    Article  CAS  PubMed  Google Scholar 

  58. PPH-Konsensus-Gruppe (D-A-CH) (2011) Postpartale Blutung—Handlungsalgorithmus nach vaginaler Geburt oder in der postoperativen Überwachungsphase nach Sectio caesarea. http://www.sgar-ssar.ch/fileadmin/user_upload/user_saoa/PPH_algorithmus_2012.pdf

  59. Prendiville WJ, Elbourne D, McDonald S (2000) Active versus expectant management in the third stage of labour. Cochrane Database Syst Rev 3:CD000007

    PubMed  Google Scholar 

  60. Pursche T, Diedrich K, Banz-Jansen C (2012) Blood loss after caesarean section: depending on the management of oxytocin application? Arch Gynecol Obstet 286:633–636

    Article  CAS  PubMed  Google Scholar 

  61. Rajan PV, Wing DA (2010) Postpartum hemorrhage: evidence-based medical interventions for prevention and treatment. Clin Obstet Gynecol 53:165–181

    Article  PubMed  Google Scholar 

  62. Rath W (2009) Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin. Eur J Obstet Gynecol Reprod Biol 147:15–20

    Article  CAS  PubMed  Google Scholar 

  63. Rath W (2011) Postpartum hemorrhage: update on problems of definitions and diagnosis. Acta Obstet Gynecol Scand 90:421–428

    Article  PubMed  Google Scholar 

  64. Rath W, Hackethal A, Bohlmann MK (2012) Second-line treatment of postpartum haemorrhage (PPH). Arch Gynecol Obstet 286:549–561

    Article  CAS  PubMed  Google Scholar 

  65. (2009) RCOG Green-top Guideline No. 52: prevention and management of post partum haemorrhage. London (UK)

  66. Ribbing M, Reinecke H, Breithardt G, Kerber S (2001) Acute anterior wall infarct in a 31-year-old patient after administration of methylergometrin for peripartal vaginal hemorrhage. Herz 26:489–493

    Article  CAS  PubMed  Google Scholar 

  67. Roach MK, Abramovici A, Tita AT (2012) Dose and duration of oxytocin to prevent postpartum hemorrhage: a review. Am J Perinatol Dec 3. (Epub ahead of print)

  68. Rogers MS, Yuen PM, Wong S (2007) Avoiding manual removal of placenta: evaluation of intra-umbilical injection of uterotonics using the Pipingas technique for management of adherent placenta. Acta Obstet Gynecol Scand 86:48–54

    Article  CAS  PubMed  Google Scholar 

  69. Rydén G, Sjöholm I (1969) Half-life of oxytocin in blood of pregnant and non-pregnant women. Acta Endocrinol (Copenh) 61:425–431

    Google Scholar 

  70. Samangaya R, Pennington R, Vause S (2010) Factors relating to a rising incidence of major postpartum haemorrhage. BJOG 117:370–371

    Article  PubMed  Google Scholar 

  71. Sartain JB, Barry JJ, Howat PW, McCormack DI, Bryant M (2008) Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section. Br J Anaesth 101:822–826

    Article  CAS  PubMed  Google Scholar 

  72. Schmitz T, Tararbit K, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C (2011) Prostaglandin E2 analogue sulprostone for treatment of atonic postpartum hemorrhage. Obstet Gynecol 118:257–265

    Article  CAS  PubMed  Google Scholar 

  73. Sekimoto E, Kunishige M, Kuriwaka R, Shinohara M, Ebisutani D, Kitamura K et al (2002) Delayed vasospasm in late postpartum cerebral angiopathy after withdrawal of methylergometrine. Cerebrovasc Dis 13:288–289

    Article  PubMed  Google Scholar 

  74. Silcox J, Schulz P, Horbay GL, Wassenaar W (1993) Transfer of carbetocin into human breast milk. Obstet Gynecol 82:456–459

    CAS  PubMed  Google Scholar 

  75. Singh G, Radhakrishnan G, Guleria K (2009) Comparison of sublingual misoprostol, intravenous oxytocin, and intravenous methylergometrine in active management of the third stage of labor. Int J Gynaecol Obstet 107:130–134

    Article  CAS  PubMed  Google Scholar 

  76. Singhi S, Chookang E, Hall JS, Kalghatgi S (1985) Iatrogenic neonatal and maternal hyponatraemia following oxytocin and aqueous glucose infusion during labour. Br J Obstet Gynaecol 92:356–363

    Article  CAS  PubMed  Google Scholar 

  77. Soltani H, Hutchon DR, Poulose TA (2010) Timing of prophylactic uterotonics for the third stage of labour after vaginal birth. Cochrane Database Syst Rev 8:CD006173

    PubMed  Google Scholar 

  78. Stefanovic V, Paavonen J, Loukovaara M, Halmesmäki E, Ahonen J, Tikkanen M (2012) Intravenous sulprostone infusion in the treatment of retained placenta. Acta Obstet Gynecol Scand Aug 1. (Epub ahead of print)

  79. Su LL, Rauff M, Chan YH, Mohamad Suphan N, Lau TP, Biswas A et al (2009) Carbetocin versus syntometrine for the third stage of labour following vaginal delivery—a double-blind randomised controlled trial. BJOG 116:1461–1466

    Article  CAS  PubMed  Google Scholar 

  80. Su LL, Chong YS, Samuel M (2012) Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev 4:CD005457

    PubMed  Google Scholar 

  81. Tamhane P, O’Sullivan G, Reynolds F (2006) Oxytocin in parturients with cardiac disease. Int J Obstet Anesth 15:332–333

    Article  CAS  PubMed  Google Scholar 

  82. Takeda S, Kuwabara Y, Mizuno M (1986) Concentrations and origin of oxytocin in breast milk. Endocrinol Jpn 33:821–826

    Article  CAS  PubMed  Google Scholar 

  83. Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC (1999) Human vascular endothelial cells express oxytocin receptors. Endocrinology 140:1301–1309

    CAS  PubMed  Google Scholar 

  84. Thilaganathan B, Cutner A, Latimer J, Beard R (1993) Management of third-stage of labour in women with low risk of postpartum haemorrhage. Eur J Obstet Gynecol Reprod Biol 48:19–22

    Article  CAS  PubMed  Google Scholar 

  85. Thomas JS, Koh SH, Cooper GM (2007) Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. Br J Anaesth 98:116–119

    Article  CAS  PubMed  Google Scholar 

  86. Tsui BC, Stewart B, Fitzmaurice A, Williams R (2001) Cardiac arrest and myocardial infarction induced by postpartum intravenous ergonovine administration. Anesthesiology 94:363–364

    Article  CAS  PubMed  Google Scholar 

  87. Upadhyay K, Scholefield H (2008) Risk management and medicolegal issues related to postpartum haemorrhage. Best Pract Res Clin Obstet Gynaecol 22:1149–1169

    Article  PubMed  Google Scholar 

  88. Vankrieken L, Godart A, Thomas K (1983) Oxytocin determination by radioimmunoassay. Gynecol Obstet Invest 16:180–185

    Article  CAS  PubMed  Google Scholar 

  89. Vincenti E, Tambuscio B, Marchesoni D, Graziottin A, Di Lenardo L, Chiaranda M (1982) Use of intramyometrial injection of prostaglandin F 2 alpha in the management of intractable hemorrhage due to uterine atony. Clin Exp Obstet Gynecol 9:26–30

    CAS  PubMed  Google Scholar 

  90. Vogel D, Burkhardt T, Rentsch K, Schweer H, Watzer B, Zimmermann R et al (2004) Misoprostol versus methylergometrine: pharmacokinetics in human milk. Am J Obstet Gynecol 191:2168–2173

    Article  CAS  PubMed  Google Scholar 

  91. Wang JY, Lin SH, Lin YF, Chen HY, Yu FC, Fu MT (2000) An unforgotten cause of acute hyponatremia: water intoxication due to oxytocin administration in a pregnant woman. Nephron 86:342–343

    Article  CAS  PubMed  Google Scholar 

  92. Waterstone M, Bewley S, Wolfe C (2001) Incidence and predictors of severe obstetric morbidity: case-control study. BMJ 322:1089–1093

    Article  CAS  PubMed  Google Scholar 

  93. WHO recommendations for the prevention of postpartum haemorrhage (2012) World Health Organisation, Geneva (Switzerland) http://apps.who.int/iris/bitstream/10665/75411/1/9789241548502_eng.pdf

  94. WHO Guidelines for the management of post partum haemorrhage and retained placenta (2009) World Health Organisation, Geneva (Switzerland)

  95. Winter C, Macfarlane A, Deneux-Tharaux C, Zhang WH, Alexander S, Brocklehurst P, Bouvier-Colle MH, Prendiville W, Cararach V, van Roosmalen J, Berbik I, Klein M, Ayres-de-Campos D, Erkkola R, Chiechi LM, Langhoff-Roos J, Stray-Pedersen B, Troeger C (2007) Variations in policies for management of the third stage of labour and the immediate management of postpartum haemorrhage in Europe. BJOG 114:845–854

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Woo C, McGlennan A (2010) Minimum effective bolus dose of oxytocin during elective Caesarean delivery. Br J Anaesth 105:91–92

    Article  CAS  PubMed  Google Scholar 

  97. http://www.webcitation.org/68ChBtEOd

  98. Belghiti J, Kayem G, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C (2011) Oxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study. BMJ Open 1:e000514

    Article  PubMed  PubMed Central  Google Scholar 

  99. Endler M, Grünewald C, Saltvedt S (2012) Epidemiology of retained placenta: oxytocin as an independent risk factor. Obstet Gynecol 119:801–809

    Article  PubMed  Google Scholar 

  100. FIGO safe motherhood and newborn health (SMNH) committee (2012) Prevention and treatment of postpartum hemorrhage in low-resource settings. Int J Gynecol Obstet 117:108–118

    Article  Google Scholar 

  101. Morlando M, Sarno L, Napolitano R, Capone A, Tessitore G, Maruotti GM, Martinelli P (2013) Placenta accreta: incidence and risk factors in an area with a particularly high rate of cesarean section. Acta Obstet Gynecol Scand 92:457–460

    Article  PubMed  Google Scholar 

  102. Potts M, Prata N, Sahin-Hodoglugil NN (2010) Maternal mortality: one death every 7 min. Lancet 375:1762–1763

    Article  PubMed  Google Scholar 

  103. http://www.who.int/medicines/publications/essentialmedicines/18th_EML_Final_web_8Jul13.pdf

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael K. Bohlmann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bohlmann, M.K., Rath, W. Medical prevention and treatment of postpartum hemorrhage: a comparison of different guidelines. Arch Gynecol Obstet 289, 555–567 (2014). https://doi.org/10.1007/s00404-013-3016-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-013-3016-4

Keywords

Navigation