Abstract
Background
Although spontaneous regression has been reported in several cancers, it is generally believed that this rare phenomenon does not occur in epithelial ovarian cancer.
Case
We presented a stage IV epithelial ovarian cancer patient with long-term disease-free survival after palliative local irradiation alone against recurrence. The recurrent supraclavicular lymph node was almost completely necrotic, and the swelling of the para-aortic lymph node spontaneously regressed.
Conclusion
The histologic features and unexpected clinical course in this patient strongly suggest that spontaneous regression occurred in recurrent epithelial ovarian cancer.
References
Everson TC, Cole WH (1966) Spontaneous regression of cancer. WB Saunders, Philadelphia, pp 11–87
O’Regan B, Hirschberg C (1993) Spontaneous remission. An annotated bibliography. Institute of Noetic Sciences, Sausalito
Julian CG (1976) Spontaneous regression in gynecologic neoplasia. Natl Cancer Inst Monogr 44:27–30
Morice P, Thoury A, Sabourin JC, Camatte S, Atallah D, Armand JP, Madelenat P, Duvillard P, Castaigne D (2003) Case 2. Spontaneous regression of peritoneal implants in borderline ovarian tumor after salpingo-oophorectomy. J Clin Oncol 15(21):3536–3538
Hoehner JC, Gestblom C, Olsen L, Pahlman S (1997) Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma. Br J Cancer 75:1185–1194
Kitanaka C, Kato K, Ijiri R, Sakurada K, Tomiyama A, Noguchi K, Nagashima Y, Nakagawara A, Momoi T, Toyoda Y, Kigasawa H, Nishi T, Shirouzu M, Yokoyama S, Tanaka Y, Kuchino Y (2002) Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression. J Natl Cancer Inst 94:358–368
Elston DM (2004) Mechanisms of regression. Clin Med Res 2:85–88
Balzer BL, Ulbright TM (2006) Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 30:858–865
Kupryjanczyk J, Dansonka-Mieszkowska A, Szymanska T, Karpinska G, Rembiszewska A, Rusin M, Konopinski R, Kraszewska E, Timorek A, Yandell DW, Stelmachow J (2000) Spontaneous apoptosis in ovarian carcinomas: a positive association with p53 gene mutation is dependent on growth fraction. Br J Cancer 82:579–583
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Fujiwaki, R., Sawada, K. Spontaneous regression in recurrent epithelial ovarian cancer . Arch Gynecol Obstet 275, 389–391 (2007). https://doi.org/10.1007/s00404-006-0253-9
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DOI: https://doi.org/10.1007/s00404-006-0253-9