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Celecoxib as a pre-emptive analgesia after arthroscopic knee surgery; a triple-blinded randomized controlled trial

  • Arthroscopy and Sports Medicine
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Background

Pre-emptive analgesia not only controls pain but also may result in the reduction of opioid consumption and related side effects following orthopedic surgeries. The purpose of the present study was to examine the therapeutic effects of celecoxib in reducing pain following the arthroscopic knee surgeries: anterior cruciate ligament (ACL) reconstruction and partial meniscectomy.

Materials and methods

In this triple-blinded, randomized, placebo-controlled clinical trial, celecoxib 400 mg and identical placebo were administered, 2 h prior to operation, to 130 patient candidates for undergoing knee arthroscopic surgery of either isolated meniscectomy or ACL reconstruction. Pain intensity, 24 h opioid consumption and the related side effects were measured at 6 and 24 h post operation.

Results

The patients in both groups were similar with regards to demographic characteristics such as age, gender and body mass index. The results of the study indicated that the pain intensity and opioid consumption were lower in both subgroups (meniscectomy and ACL-R) in celecoxib group at 6 and 24 h post operation (P < 0.0001). The side effects of analgesics such as nausea and vomiting, sedation, and dizziness were not significantly different between the two groups (P > 0.05).

Conclusion

It seems that celecoxib as a pre-emptive analgesia agent is effective in decreasing acute postoperative pain and 24 h opioid consumption in patients undergoing arthroscopic knee surgery.

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Acknowledgments

Guilan University of Medical Sciences Ethics Committee approved the study (Reference number: 1910051508) and it was registered on the Iranian Registry of Clinical Trials (IRCT no.: IRCT201205217274N5).

Conflict of interest

All named authors hereby declare that they have no conflict of interest to disclose.

Author information

Author notes

  1. Keyvan Hashemi-Motlagh

    Present address: Orthopedic Department, Poursina Hospital, Parastar Street, PO. Box: 4193713191, Rasht, Iran

Authors and Affiliations

  1. Orthopedic Department, Guilan University of Medical Sciences, Rasht, Iran

    Mohsen Mardani-Kivi

  2. Orthopedic Department, Kerman University of Medical Sciences, Kerman, Iran

    Mahmoud Karimi Mobarakeh

  3. Anesthesiology Department, Guilan University of Medical Sciences, Rasht, Iran

    Mohammad Haghighi, Bahram Naderi-Nabi & Abbas Sedighi-Nejad

  4. Orthopedic Research Center, Guilan University of Medical Sciences, Rasht, Iran

    Keyvan Hashemi-Motlagh & Khashayar Saheb-Ekhtiari

Authors
  1. Mohsen Mardani-Kivi
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  2. Mahmoud Karimi Mobarakeh
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Correspondence to Keyvan Hashemi-Motlagh.

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Mardani-Kivi, M., Karimi Mobarakeh, M., Haghighi, M. et al. Celecoxib as a pre-emptive analgesia after arthroscopic knee surgery; a triple-blinded randomized controlled trial. Arch Orthop Trauma Surg 133, 1561–1566 (2013). https://doi.org/10.1007/s00402-013-1852-0

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  • DOI: https://doi.org/10.1007/s00402-013-1852-0

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