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Silica nanocapsules for redox-responsive delivery

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Abstract

Redox-responsive silica nanocapsules with a hydrophobic liquid core were synthesized by reactive templating of miniemulsion droplets with functional alkoxysilanes. Tetrasulfide bridges were successfully introduced into the inorganic shell and were found to be accessible for chemical reactions as shown by 31P-NMR spectroscopy. Indeed, the tetrasulfide groups could be reduced to yield thiol groups. A subsequent increase of permeability of the silica shell was observed upon reduction of the tetrasulfide groups.

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Acknowledgments

Sabrina Brand is acknowledged for her help in the project. Financial support from the DFG (SPP1568) and the joint cooperation program between the Fraunhofer and the Max Planck Societies are also acknowledged.

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Authors and Affiliations

  1. Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany

    Johannes Fickert, David Schaeffel, Kaloian Koynov, Katharina Landfester & Daniel Crespy

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  1. Johannes Fickert
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  2. David Schaeffel
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  3. Kaloian Koynov
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  4. Katharina Landfester
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  5. Daniel Crespy
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Corresponding author

Correspondence to Daniel Crespy.

Electronic supplementary material

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ESM 1

experimental section, chemical strcutures of the alkoxysilanes, scheme of the reduction reaction, TEM and SEM micrographs of functional silica nanocaspules, and evaluation procedure of the FCS data. (DOCX 265 kb)

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Fickert, J., Schaeffel, D., Koynov, K. et al. Silica nanocapsules for redox-responsive delivery. Colloid Polym Sci 292, 251–255 (2014). https://doi.org/10.1007/s00396-013-3105-8

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  • DOI: https://doi.org/10.1007/s00396-013-3105-8

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