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Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features

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Abstract

Introduction

Childhood glioblastoma multiforme (GBM) is uncommon, accounting for 7.2% of the central nervous system tumors in childhood. Their clinical behaviors are almost as aggressive as those in adults, and the 5-year overall survival rate is poor.

Case report

We describe a case of a 13-year-old boy with GBM. Fourteen months after surgical resection followed by radiotherapy and temozolomide chemotherapy, the patient showed local recurrence. No response to subsequent bevacizumab treatment was observed. To determine correlations of molecular alterations with clinical outcomes in this case, we examined the expressions of Ki-67, MMP-9, MGMT, VEGF, Ras, and p-AKT using biopsies before and after recurrence.

Discussion

Childhood glioblastomas show a distinct biological behavior and probably a different molecular pathogenesis in comparison to the adult ones. Understanding the molecular mechanisms responsible for the formation and progression of the tumors is critical for identification of novel therapeutic targets.

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Authors and Affiliations

  1. Glioma Therapy Center, Beijing Tiantan Hospital, Capital Medical University, 6, Tiantan Xili, Chongwen District, Beijing, 100050, China

    Wei Zhang, Yi Lin, Baoshi Chen & Tao Jiang

  2. Cancer Research Laboratory, Beijing Shijitan Hospital, The Capital Medical University, Beijing, 100038, China

    Sonya Wei Song

Authors
  1. Wei Zhang
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  2. Yi Lin
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  3. Baoshi Chen
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  4. Sonya Wei Song
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  5. Tao Jiang
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Corresponding author

Correspondence to Tao Jiang.

Additional information

Grant support: National Key Technology R&D Program (No.2007BAI05B08) and NSFC General Projects (No.30772238).

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Zhang, W., Lin, Y., Chen, B. et al. Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features. Childs Nerv Syst 26, 137–143 (2010). https://doi.org/10.1007/s00381-009-0995-3

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  • DOI: https://doi.org/10.1007/s00381-009-0995-3

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